ID   DDX1_DROVI              Reviewed;         400 AA.
AC   Q24731;
DT   28-MAR-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 102.
DE   RecName: Full=ATP-dependent RNA helicase Ddx1;
DE            EC=3.6.4.13;
DE   AltName: Full=DEAD box protein 1;
DE   Flags: Fragment;
GN   Name=Ddx1;
OS   Drosophila virilis (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila.
OX   NCBI_TaxID=7244;
RN   [1] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Embryo;
RX   PubMed=8666277; DOI=10.1016/0378-1119(96)00034-0;
RA   Rafti F., Scarvelis D., Lasko P.F.;
RT   "A Drosophila melanogaster homologue of the human DEAD-box gene DDX1.";
RL   Gene 171:225-229(1996).
CC   -!- FUNCTION: Acts as an ATP-dependent RNA helicase, able to unwind both
CC       RNA-RNA and RNA-DNA duplexes. Possesses 5' single-stranded RNA overhang
CC       nuclease activity (By similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family. DDX1 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; U34779; AAC47310.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q24731; -.
DR   SMR; Q24731; -.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR   GO; GO:0003682; F:chromatin binding; ISS:UniProtKB.
DR   GO; GO:0033677; F:DNA/RNA helicase activity; ISS:UniProtKB.
DR   GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0004518; F:nuclease activity; ISS:UniProtKB.
DR   GO; GO:0008143; F:poly(A) binding; ISS:UniProtKB.
DR   GO; GO:0003724; F:RNA helicase activity; ISS:UniProtKB.
DR   GO; GO:0003712; F:transcription coregulator activity; ISS:UniProtKB.
DR   GO; GO:0032508; P:DNA duplex unwinding; ISS:UniProtKB.
DR   GO; GO:0006302; P:double-strand break repair; ISS:UniProtKB.
DR   GO; GO:0001700; P:embryonic development via the syncytial blastoderm; ISS:UniProtKB.
DR   GO; GO:0048477; P:oogenesis; IEA:EnsemblMetazoa.
DR   GO; GO:0007283; P:spermatogenesis; IEA:EnsemblMetazoa.
DR   GO; GO:0008033; P:tRNA processing; IEA:EnsemblMetazoa.
DR   Gene3D; 3.40.50.300; -; 2.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Exonuclease; Helicase; Hydrolase; Nuclease;
KW   Nucleotide-binding; RNA-binding.
FT   CHAIN           <1..400
FT                   /note="ATP-dependent RNA helicase Ddx1"
FT                   /id="PRO_0000054990"
FT   DOMAIN          <1..60
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
FT   DOMAIN          115..316
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00542"
FT   MOTIF           2..5
FT                   /note="DEAD box"
FT   NON_TER         1
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   400 AA;  46096 MW;  0CD14E0AA3924592 CRC64;
     DDEADRLLKQ GYTDLIERLH KQIPKITSDG CRLQMIVCSA TLHAFEVKKM AERLMHFPTW
     GDLKGEDAVP ETVHHVVCMV DPHTDSSWQQ LRQPIHTDGV HDHDNVHPTN QSPETFSQAV
     KLLKGEYCIR AIDQHKMDRA IIFCRTKQDC DNLEQHLSQR GGQRFSCVCL HGDRKPQERK
     QNLEMFKRQE VKFLICTDVA ARGLDITGLP FSKDLKYLSE NTLNFPNLAV INITLPDDKS
     NYVHRIGRVG RPESMGLAIS LVSTVPEKVW YHGEWCKTRG RSGSCIWYNE PNLLAEVEDH
     LNITIQQVVK SLDVPVNDFD GKVVYGQKNL NMGTGYEDHV EQLGPTVRKQ TDLELQSQSL
     FLKRLKRLNW FDFGLLHDPK YFHGYEYIKY INKLTLKSCV