DDX31_DICDI
ID DDX31_DICDI Reviewed; 908 AA.
AC Q869P0; Q55AM4;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 2.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Probable ATP-dependent RNA helicase ddx31;
DE EC=3.6.4.13;
DE AltName: Full=DEAD box protein 31;
GN Name=ddx31; ORFNames=DDB_G0271708;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Probable ATP-dependent RNA helicase. {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC -!- SIMILARITY: Belongs to the DEAD box helicase family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAFI02000006; EAL71544.1; -; Genomic_DNA.
DR RefSeq; XP_645498.1; XM_640406.1.
DR AlphaFoldDB; Q869P0; -.
DR SMR; Q869P0; -.
DR STRING; 44689.DDB0234202; -.
DR PaxDb; Q869P0; -.
DR PRIDE; Q869P0; -.
DR EnsemblProtists; EAL71544; EAL71544; DDB_G0271708.
DR GeneID; 8618126; -.
DR KEGG; ddi:DDB_G0271708; -.
DR dictyBase; DDB_G0271708; ddx31.
DR eggNOG; KOG0348; Eukaryota.
DR HOGENOM; CLU_003041_26_2_1; -.
DR InParanoid; Q869P0; -.
DR OMA; ARCAYQS; -.
DR PhylomeDB; Q869P0; -.
DR PRO; PR:Q869P0; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR GO; GO:0042254; P:ribosome biogenesis; IBA:GO_Central.
DR Gene3D; 3.40.50.300; -; 2.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR025313; DUF4217.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000629; RNA-helicase_DEAD-box_CS.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF13959; DUF4217; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM01178; DUF4217; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; SSF52540; 2.
DR PROSITE; PS00039; DEAD_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS51195; Q_MOTIF; 1.
PE 3: Inferred from homology;
KW ATP-binding; Helicase; Hydrolase; Nucleotide-binding; Reference proteome;
KW RNA-binding.
FT CHAIN 1..908
FT /note="Probable ATP-dependent RNA helicase ddx31"
FT /id="PRO_0000311828"
FT DOMAIN 239..422
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
FT DOMAIN 518..738
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00542"
FT REGION 55..165
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 519..590
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 872..908
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 207..236
FT /note="Q motif"
FT MOTIF 363..366
FT /note="DEAD box"
FT COMPBIAS 55..125
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 126..156
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 519..541
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 554..576
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 252..259
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
SQ SEQUENCE 908 AA; 104422 MW; A10F27FD86C828A4 CRC64;
MADEDDGLQL NICYLQRVPK KEINSKAEEE AYFKENISNN NNFTNNRAYR EKTNKNENNL
NNNKNNNNNN NNNKTYNNNN SNNSYNNNNY NNNSFNNNNN NNYNNNNSNN NNNSNNNNLN
KKPTFLEKKI QQEQKQKELK ELKGPQHHRY RNQENEESNA IESNSNNFKD KYKFAENKTK
KDEFNRPILE TIESNIKVEK SETFSSMNWG SLQLSETLVR NLVGHMKHEK PTHIQEASIT
PILKGNDALV KAQTGSGKTL SYLIPVVQKL TEQRVTRSDG CYCVIITPTR ELSSQIYEEL
QKLLKPFYWI VPGIIMGGEN RSAEKARIRK GINILVATPG RLLDHLQNTQ SFPTDNIKWC
ILDEADKLLD LGFEKDVTTI INLLDSKKRT MKFKRQNILV SATLSEGISR LASLSLTSPV
YIGLDSKVLE KGENPFQAAE KEMLQAPKQL DQFYVEVESK ERLTSLIAFI RWKTSNITID
KGDVASGNSS ANSKMIVFFS SCDSVDFHHY MFSNMKMDKE RGVKRTKKEQ IKQDKLIQQH
KQKNSKIFQT GNESDDEESD NDDSDDSDSN NSDSETDEEK EIEKQIKEAT SNPNYRVKTS
VFSVPIFKLH GELDQQTRTK TFFDFKNSPN GILLTTDVSA RGLDLPSVNW IVQYDPCSDT
KDYIHRIGRT ARLGNQGCSL LFLLPSEKKY IDHLAKFNVS VKEMKVTTIL QSLFYTSDGQ
LKKTSKSSQL ESQVHDLQLL FERFLIYDSK AKEMARCAYQ SFLRSYATHK ADVKSIFHIS
YLHLGHVSKS FALRETPTEL NKMSAGIKGA KAAKKGDEDT LQKQTADFKM KNYKSVNEFS
DGLNDQPLQR ANFHYESASG VIHNIYQRHF NRNERDEADK NSNPKEIKEK KRRLYDKKIE
SNKKFKSK
