DDX47_CAEEL
ID DDX47_CAEEL Reviewed; 489 AA.
AC P34580;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1994, sequence version 1.
DT 03-AUG-2022, entry version 154.
DE RecName: Full=Putative ATP-dependent RNA helicase T26G10.1;
DE EC=3.6.4.13;
GN ORFNames=T26G10.1;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=7906398; DOI=10.1038/368032a0;
RA Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J.,
RA Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M.,
RA Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L., Gardner A.,
RA Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M.,
RA Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C.,
RA Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A.,
RA Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M.,
RA Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K.,
RA Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L.,
RA Wilkinson-Sproat J., Wohldman P.;
RT "2.2 Mb of contiguous nucleotide sequence from chromosome III of C.
RT elegans.";
RL Nature 368:32-38(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Probable ATP-dependent RNA helicase which may be involved in
CC ribosome biogenesis. {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the DEAD box helicase family. DDX47/RRP3
CC subfamily. {ECO:0000305}.
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DR EMBL; Z29115; CAA82362.1; -; Genomic_DNA.
DR PIR; S40731; S40731.
DR RefSeq; NP_499069.1; NM_066668.6.
DR AlphaFoldDB; P34580; -.
DR SMR; P34580; -.
DR BioGRID; 41518; 4.
DR STRING; 6239.T26G10.1; -.
DR EPD; P34580; -.
DR PaxDb; P34580; -.
DR PeptideAtlas; P34580; -.
DR EnsemblMetazoa; T26G10.1.1; T26G10.1.1; WBGene00012059.
DR GeneID; 176321; -.
DR KEGG; cel:CELE_T26G10.1; -.
DR UCSC; T26G10.1; c. elegans.
DR CTD; 176321; -.
DR WormBase; T26G10.1; CE00337; WBGene00012059; -.
DR eggNOG; KOG0330; Eukaryota.
DR GeneTree; ENSGT00940000155774; -.
DR HOGENOM; CLU_003041_1_1_1; -.
DR InParanoid; P34580; -.
DR OMA; YDIELYQ; -.
DR OrthoDB; 744428at2759; -.
DR PhylomeDB; P34580; -.
DR Reactome; R-CEL-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR PRO; PR:P34580; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00012059; Expressed in germ line (C elegans) and 4 other tissues.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0043186; C:P granule; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR GO; GO:0006364; P:rRNA processing; IBA:GO_Central.
DR CDD; cd17954; DEADc_DDX47; 1.
DR Gene3D; 3.40.50.300; -; 2.
DR InterPro; IPR044765; DDX47/Rrp3_DEADc.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000629; RNA-helicase_DEAD-box_CS.
DR InterPro; IPR014014; RNA_helicase_DEAD_Q_motif.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS00039; DEAD_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS51195; Q_MOTIF; 1.
PE 3: Inferred from homology;
KW ATP-binding; Helicase; Hydrolase; Nucleotide-binding; Nucleus;
KW Reference proteome; Ribosome biogenesis; RNA-binding; rRNA processing.
FT CHAIN 1..489
FT /note="Putative ATP-dependent RNA helicase T26G10.1"
FT /id="PRO_0000055093"
FT DOMAIN 75..246
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
FT DOMAIN 257..417
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00542"
FT REGION 433..489
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 44..72
FT /note="Q motif"
FT MOTIF 194..197
FT /note="DEAD box"
FT COMPBIAS 433..462
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 88..95
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
SQ SEQUENCE 489 AA; 54228 MW; E0F18E237B64FE34 CRC64;
MSDSSSSDGE DNQKFLGNRK KNLTKKKVVT EEIEKDDEED VKEKSFAELG VSQPLCDACQ
RLGWMKPSKI QQAALPHALQ GKDVIGLAET GSGKTGAFAI PVLQSLLDHP QAFFCLVLTP
TRELAFQIGQ QFEALGSGIG LIAAVIVGGV DMAAQAMALA RRPHIIVATP GRLVDHLENT
KGFNLKALKF LIMDEADRIL NMDFEVELDK ILKVIPRERR TYLFSATMTK KVSKLERASL
RDPARVSVSS RYKTVDNLKQ HYIFVPNKYK ETYLVYLLNE HAGNSAIVFC ATCATTMQIA
VMLRQLGMQA VPLHGQMSQE KRLGSLNKFK SKAREILVCT DVAARGLDIP HVDMVINYDM
PSQSKDYVHR VGRTARAGRS GIAITVVTQY DVEAYQKIEA NLGKKLDEYK CVENEVMVLV
ERTQEATENA RIEMKEMDEK KKSGKKRRQN DDFGDTEESG GRFKMGIKSM GGRGGSGGGR
GGKKKKMSK
