ID   DDX49_MOUSE             Reviewed;         480 AA.
AC   Q4FZF3;
DT   27-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   30-AUG-2005, sequence version 1.
DT   03-AUG-2022, entry version 118.
DE   RecName: Full=Probable ATP-dependent RNA helicase DDX49;
DE            EC=3.6.4.13;
DE   AltName: Full=DEAD box protein 49;
GN   Name=Ddx49;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Liver;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family. DDX49/DBP8
CC       subfamily. {ECO:0000305}.
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DR   EMBL; BC099554; AAH99554.1; -; mRNA.
DR   CCDS; CCDS22364.1; -.
DR   RefSeq; NP_001020093.2; NM_001024922.2.
DR   AlphaFoldDB; Q4FZF3; -.
DR   SMR; Q4FZF3; -.
DR   BioGRID; 231521; 1.
DR   STRING; 10090.ENSMUSP00000008004; -.
DR   iPTMnet; Q4FZF3; -.
DR   PhosphoSitePlus; Q4FZF3; -.
DR   EPD; Q4FZF3; -.
DR   MaxQB; Q4FZF3; -.
DR   PaxDb; Q4FZF3; -.
DR   PeptideAtlas; Q4FZF3; -.
DR   PRIDE; Q4FZF3; -.
DR   ProteomicsDB; 279904; -.
DR   Antibodypedia; 15208; 138 antibodies from 23 providers.
DR   DNASU; 234374; -.
DR   Ensembl; ENSMUST00000008004; ENSMUSP00000008004; ENSMUSG00000057788.
DR   GeneID; 234374; -.
DR   KEGG; mmu:234374; -.
DR   UCSC; uc009lzu.1; mouse.
DR   CTD; 54555; -.
DR   MGI; MGI:2136689; Ddx49.
DR   VEuPathDB; HostDB:ENSMUSG00000057788; -.
DR   eggNOG; KOG0333; Eukaryota.
DR   eggNOG; KOG0340; Eukaryota.
DR   GeneTree; ENSGT00730000111231; -.
DR   HOGENOM; CLU_003041_1_1_1; -.
DR   InParanoid; Q4FZF3; -.
DR   OMA; EIKQESM; -.
DR   OrthoDB; 744428at2759; -.
DR   PhylomeDB; Q4FZF3; -.
DR   TreeFam; TF320511; -.
DR   Reactome; R-MMU-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR   BioGRID-ORCS; 234374; 24 hits in 74 CRISPR screens.
DR   PRO; PR:Q4FZF3; -.
DR   Proteomes; UP000000589; Chromosome 8.
DR   RNAct; Q4FZF3; protein.
DR   Bgee; ENSMUSG00000057788; Expressed in embryonic brain and 197 other tissues.
DR   Genevisible; Q4FZF3; MM.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR   GO; GO:0030307; P:positive regulation of cell growth; ISO:MGI.
DR   GO; GO:0044357; P:regulation of rRNA stability; ISO:MGI.
DR   GO; GO:0006364; P:rRNA processing; IBA:GO_Central.
DR   Gene3D; 3.40.50.300; -; 2.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000629; RNA-helicase_DEAD-box_CS.
DR   InterPro; IPR014014; RNA_helicase_DEAD_Q_motif.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00039; DEAD_ATP_HELICASE; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS51195; Q_MOTIF; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Helicase; Hydrolase; Nucleotide-binding; Reference proteome;
KW   RNA-binding.
FT   CHAIN           1..480
FT                   /note="Probable ATP-dependent RNA helicase DDX49"
FT                   /id="PRO_0000055053"
FT   DOMAIN          33..207
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
FT   DOMAIN          218..382
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00542"
FT   REGION          438..480
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           2..30
FT                   /note="Q motif"
FT   MOTIF           152..155
FT                   /note="DEAD box"
FT   BINDING         46..53
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
SQ   SEQUENCE   480 AA;  54094 MW;  526E8383D5CF8933 CRC64;
     MAGFAEIGLS SWLVEQCRQL GLKQPTPVQL GCIPAILEGR DCLGCAKTGS GKTAAFVLPI
     LQKLSEDPYG IFCLVLTPTR ELAYQIAEQF RVLGKPLGLK DCIIVGGMDM VAQALELSRK
     PHVVIATPGR LADHLRSSNT FNMKKIQFLV MDEADRLLEQ GCTDFTTDLE TILAAVPARR
     QTLLFSATLT DTLKELQGLA TNEPFFWEAQ ATVRTVEQLD QRYLLVPEKV KDAYLVHLVQ
     TFQDQLEDCS IIIFTNTCKT CQILCMMLRK FNFPTVALHS MMKQKERFAA LAKFKSSIYR
     ILIATDVASR GLDIPTVQVV INHNTPGLPK IYIHRVGRTA RAGRQGQAIT LVTQYDIHLL
     HAIEEQIKQQ LAELVVEEAE VLQILTQVNV VRRECEIKLE ASHFDEKKEI NKRKQMILEG
     KDPDLEAKRK AELAKIKQQN RRFKEKVGQT LRRQKAGSTV RRSRPPRSRP QEPAQAEAQD