ID   DDX52_BOVIN             Reviewed;         596 AA.
AC   A5D7C1;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   12-JUN-2007, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Probable ATP-dependent RNA helicase DDX52;
DE            EC=3.6.4.13;
DE   AltName: Full=DEAD box protein 52;
GN   Name=DDX52;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Hippocampus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family. DDX52/ROK1
CC       subfamily. {ECO:0000305}.
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DR   EMBL; BC140501; AAI40502.1; -; mRNA.
DR   RefSeq; NP_001096708.1; NM_001103238.1.
DR   AlphaFoldDB; A5D7C1; -.
DR   SMR; A5D7C1; -.
DR   STRING; 9913.ENSBTAP00000013622; -.
DR   PaxDb; A5D7C1; -.
DR   PRIDE; A5D7C1; -.
DR   Ensembl; ENSBTAT00000013622; ENSBTAP00000013622; ENSBTAG00000010313.
DR   GeneID; 510826; -.
DR   KEGG; bta:510826; -.
DR   CTD; 11056; -.
DR   VEuPathDB; HostDB:ENSBTAG00000010313; -.
DR   VGNC; VGNC:27975; DDX52.
DR   eggNOG; KOG0344; Eukaryota.
DR   GeneTree; ENSGT00550000074863; -.
DR   HOGENOM; CLU_003041_1_4_1; -.
DR   InParanoid; A5D7C1; -.
DR   OMA; IRAQHRI; -.
DR   OrthoDB; 400908at2759; -.
DR   TreeFam; TF314448; -.
DR   Proteomes; UP000009136; Chromosome 19.
DR   Bgee; ENSBTAG00000010313; Expressed in conceptus and 108 other tissues.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR   GO; GO:0030490; P:maturation of SSU-rRNA; IBA:GO_Central.
DR   CDD; cd17957; DEADc_DDX52; 1.
DR   Gene3D; 3.40.50.300; -; 2.
DR   InterPro; IPR044764; DDX52/Rok1_DEADc.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR014014; RNA_helicase_DEAD_Q_motif.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS51195; Q_MOTIF; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; ATP-binding; Helicase; Hydrolase; Nucleotide-binding; Nucleus;
KW   Phosphoprotein; Reference proteome; RNA-binding.
FT   CHAIN           1..596
FT                   /note="Probable ATP-dependent RNA helicase DDX52"
FT                   /id="PRO_0000310277"
FT   DOMAIN          194..372
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
FT   DOMAIN          383..544
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00542"
FT   REGION          68..94
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          575..596
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           163..191
FT                   /note="Q motif"
FT   MOTIF           316..319
FT                   /note="DEAD box"
FT   COMPBIAS        68..82
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         207..214
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
FT   MOD_RES         15
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y2R4"
FT   MOD_RES         39
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y2R4"
SQ   SEQUENCE   596 AA;  67509 MW;  EEB3351DCB2A231F CRC64;
     MDAHDLFRRL GVGAKFDLRR FSADAARFQI GKRKYDFDSS EVLQGLDFFG NKKPVPGDCG
     ALRTHQELPD EEKTEESQIE RKKQNRKKKK ITSEITSEEE VSTIQWISSV EAKIEDKNVK
     RKNKLTSGKL EQLRKEKLNF FRNKHKIHVQ GTDLPDPIAT FQQLDQEYKI NSRLLQNILD
     AGFQTPTPIQ MQAIPVMLHG RELLASAPTG SGKTLAFSIP ILMHLKQPTN KGFRALIISP
     TRELASQIHR ELVKLSEGTG FRIHMIHKAA VAAKKFGPKS SKKFDILVTT PNRLIYLLKQ
     DPPGIDLTSV EWLVVDESDK LFEDGKTGFR DQLASIFLAC TSHKVKRAMF SATFAYDVEQ
     WCRLNLDSVI TVSVGARNSA VETVEQELLF VGSETGKLLA MRELVKKGFN PPVLVFVQSI
     ERAKELFHEL IYEGINVDVI HADRTQQQRD NTVHSFRAGK IWVLICTALL ARGIDFKGVN
     LVINYDFPTS SVEYIHRIGR TGRAGHKGKA VTFFTEDDKP LLRSVANVIQ QAGCPVPEYI
     KGFQKLLSKQ KKKMIKKPLE RESISTTPKY FLEKAKDKRK KVTGQNKKKV APEDKS