位置:首页 > 蛋白库 > DDX54_DICDI
DDX54_DICDI
ID   DDX54_DICDI             Reviewed;        1091 AA.
AC   Q54CD8; Q23908;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=ATP-dependent RNA helicase ddx54;
DE            EC=3.6.4.13;
DE   AltName: Full=ATP-dependent RNA helicase helA;
DE   AltName: Full=DEAD box protein 54;
GN   Name=helA; Synonyms=ddx54; ORFNames=DDB_G0292992;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 277-374.
RC   STRAIN=AX2;
RX   PubMed=7695838; DOI=10.1515/bchm3.1994.375.11.759;
RA   Mahal B., Nellen W.;
RT   "Developmental regulation of DEAD box proteins and cloning of putative RNA
RT   helicase genes from Dictyostelium discoideum.";
RL   Biol. Chem. Hoppe-Seyler 375:759-763(1994).
CC   -!- FUNCTION: ATP-binding RNA helicase which may be involved in the
CC       ribosome biogenesis. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- DOMAIN: The Q motif is unique to and characteristic of the DEAD box
CC       family of RNA helicases and controls ATP binding and hydrolysis.
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family. DDX54/DBP10
CC       subfamily. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AAFI02000199; EAL60848.1; -; Genomic_DNA.
DR   EMBL; X81822; CAA57416.1; -; Genomic_DNA.
DR   RefSeq; XP_629281.1; XM_629279.1.
DR   AlphaFoldDB; Q54CD8; -.
DR   SMR; Q54CD8; -.
DR   STRING; 44689.DDB0215372; -.
DR   PaxDb; Q54CD8; -.
DR   PRIDE; Q54CD8; -.
DR   EnsemblProtists; EAL60848; EAL60848; DDB_G0292992.
DR   GeneID; 8629004; -.
DR   KEGG; ddi:DDB_G0292992; -.
DR   dictyBase; DDB_G0292992; helA.
DR   eggNOG; KOG0337; Eukaryota.
DR   HOGENOM; CLU_003041_5_2_1; -.
DR   InParanoid; Q54CD8; -.
DR   OMA; MRWDKKS; -.
DR   PhylomeDB; Q54CD8; -.
DR   PRO; PR:Q54CD8; -.
DR   Proteomes; UP000002195; Chromosome 6.
DR   GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006364; P:rRNA processing; IBA:GO_Central.
DR   Gene3D; 3.40.50.300; -; 2.
DR   InterPro; IPR012541; DBP10_C.
DR   InterPro; IPR033517; DDX54/DBP10.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000629; RNA-helicase_DEAD-box_CS.
DR   InterPro; IPR014014; RNA_helicase_DEAD_Q_motif.
DR   PANTHER; PTHR24031:SF292; PTHR24031:SF292; 1.
DR   Pfam; PF08147; DBP10CT; 1.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   SMART; SM01123; DBP10CT; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   PROSITE; PS00039; DEAD_ATP_HELICASE; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS51195; Q_MOTIF; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Helicase; Hydrolase; Nucleotide-binding; Nucleus;
KW   Reference proteome; Ribosome biogenesis; RNA-binding; rRNA processing.
FT   CHAIN           1..1091
FT                   /note="ATP-dependent RNA helicase ddx54"
FT                   /id="PRO_0000327438"
FT   DOMAIN          261..433
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
FT   DOMAIN          478..632
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00542"
FT   REGION          1..63
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          150..231
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          801..896
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          933..1091
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           230..258
FT                   /note="Q motif"
FT   MOTIF           381..384
FT                   /note="DEAD box"
FT   COMPBIAS        13..36
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        37..52
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        169..231
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        807..823
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        824..853
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        854..882
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        933..994
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1004..1056
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         274..281
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
FT   CONFLICT        344..345
FT                   /note="FT -> LH (in Ref. 2; CAA57416)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        350
FT                   /note="N -> Y (in Ref. 2; CAA57416)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        355
FT                   /note="I -> L (in Ref. 2; CAA57416)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   1091 AA;  125085 MW;  23F859D1A9D1D231 CRC64;
     MVKPNNVKIK NKGNLKKSNE SQNDYMKGKK LETKSYQKAL LSKNSNNNND GAQAKRLKKK
     EEFKKKLEKR QNTIVIKDKL KEPSTFLKED QSFFDQNIFN DQDDYKHQQM NRININENFE
     TNLFGDMMNE FDGDLNEDLD LLDYNDEVID NSNFDNNGDQ FNSEDEEFYD DEKQAKKSNK
     NKNADADNKK SKKSNKKEEI ESSEKFESFP MDENNEQEEE TTSKKKKKTG GFQSMDLTKN
     LLKAILKKGF NVPTPIQRKS IPMILDGHDI VGMARTGSGK TGAFVIPMIQ KLGDHSTTVG
     VRAVILSPTR ELAIQTFKVV KDFSQGTQLR TILIVGGDSM EDQFTDLARN PDIIIATPGR
     LMHHLLETGM SLSKVQYIVF DEADRLFEMG FNEQLTEILS KLSENRQTLL FSATLPSLLV
     DFVRAGLNNP KLINLDTDTK ISENLSLSFF TLRHEEKLGV LLFLLKDIIY KKPQLPTTET
     TTTTTTNNES NQQQQKKSST IIFVSTKYHV EFIHILLERA GIASTYIHGY LDPVARKINL
     AKFRSHQVGV MVVTDLAARG IDIPLLDNVI NFDFPPKEKI FIHRVGRVAR AGRSGIAYSL
     VSPDEVPYMI DLHLYLGRKF LNKFQYEGQT INDPKYSFYG TIPQTIIDRE TEFVNVQRKE
     CIELLSLTKT IHNAHKKYLS TRPGASHESN RRAKLMDKSK YHPMLSDHLN SNDQIRNDFI
     QSLKSFRPPQ TVLELDARKN NVQVSIMKDK RKVHTNVIES QQKKLYLQQS ETNLGPENEE
     FDYSKLDTRK RLLQLTENIT EEMLRSNKSN DNNDNNKDIK MNENDDENDD DDEEGENDDD
     EEEENEKDED DEEDENKNKF NIKIESSDKN DNNKKKLKSR SSSRDPNFFI SATPENLIQE
     RAMSISNRFT KDDEVNLVAD TDRKQKKSMV WDKRKGKFVS SQADADRKNS KKLVRNEAGK
     LVEAKKSHKG YEEWKKKTHG RIQRVGEDEN SKYQPNQKEY LPQKWRGQGR EKEKKDNKAS
     HAKGSHGLKG RPSELKDKNQ ISKNRSEKER KMRVNKTKGN PKGSKSKSGG GGGGKGSKFG
     SGKSKGGKSR K
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024