DDX55_CAEEL
ID DDX55_CAEEL Reviewed; 578 AA.
AC P34640;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1996, sequence version 2.
DT 03-AUG-2022, entry version 156.
DE RecName: Full=Probable ATP-dependent RNA helicase DDX55 homolog;
DE EC=3.6.4.13;
DE AltName: Full=DEAD box protein 55;
GN ORFNames=ZK512.2;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=7906398; DOI=10.1038/368032a0;
RA Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J.,
RA Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M.,
RA Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L., Gardner A.,
RA Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M.,
RA Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C.,
RA Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A.,
RA Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M.,
RA Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K.,
RA Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L.,
RA Wilkinson-Sproat J., Wohldman P.;
RT "2.2 Mb of contiguous nucleotide sequence from chromosome III of C.
RT elegans.";
RL Nature 368:32-38(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Probable ATP-binding RNA helicase.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC -!- DOMAIN: The Q motif is unique to and characteristic of the DEAD box
CC family of RNA helicases and controls ATP binding and hydrolysis.
CC -!- SIMILARITY: Belongs to the DEAD box helicase family. DDX55/SPB4
CC subfamily. {ECO:0000305}.
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DR EMBL; Z22177; CAA80151.1; -; Genomic_DNA.
DR PIR; B88549; B88549.
DR PIR; S40763; S40763.
DR RefSeq; NP_001254980.1; NM_001268051.1.
DR AlphaFoldDB; P34640; -.
DR SMR; P34640; -.
DR BioGRID; 41491; 1.
DR STRING; 6239.ZK512.2a; -.
DR EPD; P34640; -.
DR PaxDb; P34640; -.
DR PeptideAtlas; P34640; -.
DR PRIDE; P34640; -.
DR EnsemblMetazoa; ZK512.2a.1; ZK512.2a.1; WBGene00013983.
DR GeneID; 176292; -.
DR KEGG; cel:CELE_ZK512.2; -.
DR UCSC; ZK512.2; c. elegans.
DR CTD; 176292; -.
DR WormBase; ZK512.2a; CE03821; WBGene00013983; -.
DR eggNOG; KOG0345; Eukaryota.
DR GeneTree; ENSGT00550000074969; -.
DR HOGENOM; CLU_003041_26_4_1; -.
DR InParanoid; P34640; -.
DR OMA; IQFEDHM; -.
DR OrthoDB; 973872at2759; -.
DR PhylomeDB; P34640; -.
DR PRO; PR:P34640; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00013983; Expressed in germ line (C elegans) and 4 other tissues.
DR ExpressionAtlas; P34640; baseline and differential.
DR GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR GO; GO:0043186; C:P granule; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR Gene3D; 3.40.50.300; -; 2.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR025313; DUF4217.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000629; RNA-helicase_DEAD-box_CS.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF13959; DUF4217; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM01178; DUF4217; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS00039; DEAD_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding; Helicase; Hydrolase; Nucleotide-binding; Reference proteome;
KW RNA-binding.
FT CHAIN 1..578
FT /note="Probable ATP-dependent RNA helicase DDX55 homolog"
FT /id="PRO_0000055094"
FT DOMAIN 40..218
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
FT DOMAIN 231..393
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00542"
FT REGION 507..557
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 7..37
FT /note="Q motif"
FT MOTIF 166..169
FT /note="DEAD box"
FT COMPBIAS 533..557
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 53..60
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
SQ SEQUENCE 578 AA; 65828 MW; 50284E264B064A88 CRC64;
MTSKVGPVAL KTFREKLGPE LLEVFDKSYK SFTDVQVLSG THLLNLSDVV VESPTGSGKT
LAFVLPMMRM IQNAKLQPAD IGALILSPSR ELCSQIVSVI QPFAEKLNLT VETVTGGQKV
DKNIKMFKNK NVNILVATPG RLFQIIQHEK TLIARKMRTL QLLVIDEADR FNEIQFEDHM
REILSCIPKQ RRTGLFSATQ VKEEDDLMVF GLRNAKQVKV AQERNSAAPS TLKNYYVECR
ADEKTSVCLE FIRQRTDKKI LIFFPSCNSV RYFYKIFERC LGKRPLFAVH GKCSNPHRAS
QIKAFSDSTN GVMISTDVMA RGIDISDIDW VIQFDLPKHS SWFVHRAGRT ARCGREGNAL
ILIASEQLAY VNFLDNHEKV KLDEIKVPTN NSRKSEELRQ KMIKIQVSDR AILEAGTRAF
VSHVESYAKH DCHLICSLDD LNVVGLANSY ALLRLPKMRE LSQRKDLDMF DRSAIETSEI
KYADVKLEAN RETVMKEKHE KKVETLAAKD KKRREKEARK LKKMGGRFRN GGGTGRKAEE
KKALKRKAEE EDDAQNDIRL LKRIKRGKLS KKEIKDVL
