ID   DDX56_BOVIN             Reviewed;         546 AA.
AC   Q3SZ40;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=Probable ATP-dependent RNA helicase DDX56;
DE            EC=3.6.4.13;
DE   AltName: Full=DEAD box protein 56;
GN   Name=DDX56;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Hypothalamus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play a role in later stages of the processing of the pre-
CC       ribosomal particles leading to mature 60S ribosomal subunits. Has
CC       intrinsic ATPase activity (By similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC   -!- SUBUNIT: May form homooligomeric complexes. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family. DDX56/DBP9
CC       subfamily. {ECO:0000305}.
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DR   EMBL; BC103169; AAI03170.1; -; mRNA.
DR   RefSeq; NP_001029501.1; NM_001034329.2.
DR   AlphaFoldDB; Q3SZ40; -.
DR   SMR; Q3SZ40; -.
DR   STRING; 9913.ENSBTAP00000014014; -.
DR   PaxDb; Q3SZ40; -.
DR   PRIDE; Q3SZ40; -.
DR   Ensembl; ENSBTAT00000014014; ENSBTAP00000014014; ENSBTAG00000010602.
DR   GeneID; 508728; -.
DR   KEGG; bta:508728; -.
DR   CTD; 54606; -.
DR   VEuPathDB; HostDB:ENSBTAG00000010602; -.
DR   VGNC; VGNC:27978; DDX56.
DR   eggNOG; KOG0346; Eukaryota.
DR   GeneTree; ENSGT00550000074946; -.
DR   HOGENOM; CLU_003041_17_1_1; -.
DR   InParanoid; Q3SZ40; -.
DR   OMA; GYEKDFK; -.
DR   OrthoDB; 973872at2759; -.
DR   TreeFam; TF300620; -.
DR   Proteomes; UP000009136; Chromosome 4.
DR   Bgee; ENSBTAG00000010602; Expressed in gluteus medius and 105 other tissues.
DR   GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 2.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR014014; RNA_helicase_DEAD_Q_motif.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS51195; Q_MOTIF; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Helicase; Hydrolase; Nucleotide-binding; Nucleus;
KW   Phosphoprotein; Reference proteome; Ribosome biogenesis; RNA-binding;
KW   rRNA processing.
FT   CHAIN           1..546
FT                   /note="Probable ATP-dependent RNA helicase DDX56"
FT                   /id="PRO_0000282326"
FT   DOMAIN          38..218
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
FT   DOMAIN          230..424
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00542"
FT   REGION          323..342
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          504..546
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           7..35
FT                   /note="Q motif"
FT   MOTIF           166..169
FT                   /note="DEAD box"
FT   COMPBIAS        504..529
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         51..58
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
FT   MOD_RES         126
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NY93"
FT   MOD_RES         141
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NY93"
FT   MOD_RES         531
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NY93"
SQ   SEQUENCE   546 AA;  61254 MW;  0E3E4A6F09983404 CRC64;
     MEDPESLGFE HMGLDHRLLQ AVTDLGWSRP TLIQEKAIPL ALEGKDLLAR ARTGSGKTAA
     YAIPMLQLLL HRKATGPVVE QAVRALVLVP TKELARQAQS MIQQLAAYCA RDIRVANVSA
     AEDSASQRAV LMEKPDVVVG TPSRILNHLQ QDNLKLRDSM ELLVVDEADL LFSFGFEEEL
     KSLLCHLPRI YQAFLMSATF NEDVQALKEL VLHNPVTLKL QESQLPGPDQ LQQFQVVCET
     EEDKFLLLYA LLKLSLIRGK SLLFVNTLER SYRLRLFLEQ FSIPACVLNG ELPLRSRCHI
     ISQFNQGFYD CVIATDAEVL GPPVKGKHRG KGPKRDKASD PEAGVARGID FHHVCAVLNF
     DLPPTPEAYI HRAGRTARAN NPGIVLTFVL PTEQSQLGKI EELLSGDSGA PVLLPYQFHM
     EEIEGFRYRC RDAMRSVTKQ AIREARLKEI KEELLHSEKL KTYFEDNPRD LQLLRHDLPL
     HPAVVKPHLG NVPDYLVPPA LRGLVHPHKK RKKPLASKKA KKAKTQNPLR SFKHRGEKCR
     PTAAPS