DEAL2_ARATH
ID DEAL2_ARATH Reviewed; 168 AA.
AC O81898;
DT 23-FEB-2022, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=Protein DESIGUAL 2 {ECO:0000303|PubMed:29139551};
DE Flags: Precursor;
GN Name=DEAL2 {ECO:0000303|PubMed:29139551};
GN OrderedLocusNames=At4g21310 {ECO:0000312|EMBL:AEE84438.1};
GN ORFNames=T6K22.40 {ECO:0000312|EMBL:CAA20196.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Cheuk R.F., Chen H., Kim C.J., Shinn P., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP FUNCTION, DISRUPTION PHENOTYPE, TISSUE SPECIFICITY, GENE FAMILY, AND
RP NOMENCLATURE.
RC STRAIN=cv. Columbia;
RX PubMed=29139551; DOI=10.1111/nph.14898;
RA Wilson-Sanchez D., Martinez-Lopez S., Navarro-Cartagena S., Jover-Gil S.,
RA Micol J.L.;
RT "Members of the DEAL subfamily of the DUF1218 gene family are required for
RT bilateral symmetry but not for dorsoventrality in Arabidopsis leaves.";
RL New Phytol. 217:1307-1321(2018).
CC -!- FUNCTION: Involved, partially redundantly with VCC/DEAL1 and DEAL3, to
CC ensure bilateral symmetry development and early leaf margin patterning,
CC probably via the regulation of auxin and CUC2 distribution.
CC {ECO:0000269|PubMed:29139551}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000250|UniProtKB:Q9ZV57}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- TISSUE SPECIFICITY: Mainly expressed in roots, inflorescences and
CC developing leaves, and, at low levels, in mature leaves.
CC {ECO:0000269|PubMed:29139551}.
CC -!- DISRUPTION PHENOTYPE: Developmental defects of pistils, some being bent
CC or coiled or twisted, and some showing unfused carpels with exposed
CC ovules (PubMed:29139551). The vcc-3 deal2-1 double mutant shows leaf
CC asymmetry (PubMed:29139551). The vcc-3 deal2-1 deal3-1 triple mutant
CC shows a strong leaf asymmetry (PubMed:29139551).
CC {ECO:0000269|PubMed:29139551}.
CC -!- SIMILARITY: Belongs to the DESIGUAL family. {ECO:0000305}.
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DR EMBL; AL031187; CAA20196.1; -; Genomic_DNA.
DR EMBL; AL161554; CAB79130.1; -; Genomic_DNA.
DR EMBL; CP002687; AEE84438.1; -; Genomic_DNA.
DR EMBL; BT014771; AAT41754.1; -; mRNA.
DR EMBL; BT015009; AAT70460.1; -; mRNA.
DR PIR; T05173; T05173.
DR RefSeq; NP_193862.1; NM_118249.8.
DR AlphaFoldDB; O81898; -.
DR SMR; O81898; -.
DR STRING; 3702.AT4G21310.1; -.
DR MetOSite; O81898; -.
DR PaxDb; O81898; -.
DR PRIDE; O81898; -.
DR EnsemblPlants; AT4G21310.1; AT4G21310.1; AT4G21310.
DR GeneID; 827879; -.
DR Gramene; AT4G21310.1; AT4G21310.1; AT4G21310.
DR Araport; AT4G21310; -.
DR TAIR; locus:2141186; AT4G21310.
DR eggNOG; ENOG502RXRV; Eukaryota.
DR HOGENOM; CLU_103513_0_0_1; -.
DR InParanoid; O81898; -.
DR OMA; RMWIFEC; -.
DR OrthoDB; 1382746at2759; -.
DR PhylomeDB; O81898; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; O81898; baseline and differential.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0009855; P:determination of bilateral symmetry; IMP:UniProtKB.
DR GO; GO:0048366; P:leaf development; IMP:UniProtKB.
DR InterPro; IPR009606; DEAL/Modifying_wall_lignin1/2.
DR Pfam; PF06749; DUF1218; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; Endoplasmic reticulum; Membrane; Reference proteome;
KW Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..168
FT /note="Protein DESIGUAL 2"
FT /id="PRO_5014306629"
FT TRANSMEM 56..76
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 94..114
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 133..153
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 168 AA; 18141 MW; 781779CCA345F242 CRC64;
MARNVGFFIC ILILAMDVSA GILGIEAEIA QNKVKHLKMW IFECRDPSYT AFKYGLAACI
LLVLAHVTAN FLGGCLCVAS RQDLEKSSAN KQLAVASLIF TWIILAIAFS MLIVGTMANS
RSRKNCGISH HRVLSIGGIL CFVHGLFAVA YYISATASTR EQTSAGHA
