DEAL3_ARATH
ID DEAL3_ARATH Reviewed; 184 AA.
AC A2RVQ4;
DT 23-FEB-2022, integrated into UniProtKB/Swiss-Prot.
DT 06-MAR-2007, sequence version 1.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=Protein DESIGUAL 3 {ECO:0000303|PubMed:29139551};
DE Flags: Precursor;
GN Name=DEAL3 {ECO:0000303|PubMed:29139551};
GN OrderedLocusNames=At1g11500 {ECO:0000312|Araport:AT1G11500};
GN ORFNames=T23J18.31 {ECO:0000312|EMBL:AC011661};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Bautista V.R., Kim C.J., Chen H., Wu S.Y., De Los Reyes C., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP FUNCTION, DISRUPTION PHENOTYPE, TISSUE SPECIFICITY, GENE FAMILY, AND
RP NOMENCLATURE.
RC STRAIN=cv. Columbia;
RX PubMed=29139551; DOI=10.1111/nph.14898;
RA Wilson-Sanchez D., Martinez-Lopez S., Navarro-Cartagena S., Jover-Gil S.,
RA Micol J.L.;
RT "Members of the DEAL subfamily of the DUF1218 gene family are required for
RT bilateral symmetry but not for dorsoventrality in Arabidopsis leaves.";
RL New Phytol. 217:1307-1321(2018).
CC -!- FUNCTION: Involved, partially redundantly with VCC/DEAL1 and DEAL2, to
CC ensure bilateral symmetry development and early leaf margin patterning,
CC probably via the regulation of auxin and CUC2 distribution.
CC {ECO:0000269|PubMed:29139551}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000250|UniProtKB:Q9ZV57}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- TISSUE SPECIFICITY: Mainly expressed in roots, inflorescences and
CC developing leaves, and, at low levels, in mature leaves.
CC {ECO:0000269|PubMed:29139551}.
CC -!- DISRUPTION PHENOTYPE: No visible phenotype (PubMed:29139551). The vcc-3
CC deal3-1 double mutant shows leaf asymmetry (PubMed:29139551). The vcc-3
CC deal2-1 deal3-1 triple mutant shows a strong leaf asymmetry
CC (PubMed:29139551). {ECO:0000269|PubMed:29139551}.
CC -!- SIMILARITY: Belongs to the DESIGUAL family. {ECO:0000305}.
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DR EMBL; AC011661; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CP002684; AEE28745.1; -; Genomic_DNA.
DR EMBL; BT030045; ABN04783.1; -; mRNA.
DR RefSeq; NP_172617.2; NM_101023.3.
DR PaxDb; A2RVQ4; -.
DR ProteomicsDB; 183208; -.
DR EnsemblPlants; AT1G11500.1; AT1G11500.1; AT1G11500.
DR GeneID; 837693; -.
DR Gramene; AT1G11500.1; AT1G11500.1; AT1G11500.
DR Araport; AT1G11500; -.
DR TAIR; locus:2200071; AT1G11500.
DR eggNOG; ENOG502RXRV; Eukaryota.
DR HOGENOM; CLU_103513_0_0_1; -.
DR InParanoid; A2RVQ4; -.
DR PhylomeDB; A2RVQ4; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; A2RVQ4; baseline and differential.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0009855; P:determination of bilateral symmetry; IMP:UniProtKB.
DR GO; GO:0048366; P:leaf development; IMP:UniProtKB.
DR InterPro; IPR009606; DEAL/Modifying_wall_lignin1/2.
DR Pfam; PF06749; DUF1218; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; Endoplasmic reticulum; Glycoprotein; Membrane;
KW Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT CHAIN 25..184
FT /note="Protein DESIGUAL 3"
FT /id="PRO_5014296826"
FT TRANSMEM 62..82
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 99..119
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 34..53
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 180
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ SEQUENCE 184 AA; 20045 MW; 11FF0C8E11106C2E CRC64;
MESELGFLVS VVIICADITA TVLGIEAEIA QSKAPHHHHQ QHSRHSGSGC RRSPSDGAFA
EGVAAMVLLF IVHVLANVLG GCTYIRSKQD FKRATANKIL AVAFLVLSWI FFVVSYSTLM
IGTLANSRTN RLCSLPHRWF FLIGGIFCLG HGVVTSAYYV SAIAAKKEDK ENAQQENLAN
RSRA
