ID   DEAR_MOUSE              Reviewed;         127 AA.
AC   Q2QKR2;
DT   23-FEB-2022, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   03-AUG-2022, entry version 39.
DE   RecName: Full=Dual endothelin-1/angiotensin II receptor {ECO:0000303|PubMed:16293765};
DE            Short=Dear {ECO:0000303|PubMed:16293765};
DE   AltName: Full=Dual endothelin-1/VEGFsp receptor {ECO:0000250|UniProtKB:B0L3A2};
DE            Short=DEspR protein {ECO:0000250|UniProtKB:B0L3A2};
DE   AltName: Full=FBXW7 antisense RNA 1 homolog {ECO:0000250|UniProtKB:B0L3A2};
GN   Name=Fbxw7-as1 {ECO:0000250|UniProtKB:B0L3A2};
GN   Synonyms=Dear {ECO:0000303|PubMed:16293765},
GN   Dear1 {ECO:0000312|MGI:MGI:3614654},
GN   Fbxw7as1 {ECO:0000312|MGI:MGI:3614654};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DISRUPTION PHENOTYPE,
RP   DEVELOPMENTAL STAGE, FUNCTION, AND SUBCELLULAR LOCATION.
RC   STRAIN=C57BL/6J;
RX   PubMed=16293765; DOI=10.1152/physiolgenomics.00144.2005;
RA   Herrera V.L., Ponce L.R., Bagamasbad P.D., VanPelt B.D., Didishvili T.,
RA   Ruiz-Opazo N.;
RT   "Embryonic lethality in Dear gene-deficient mice: new player in
RT   angiogenesis.";
RL   Physiol. Genomics 23:257-268(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
CC   -!- FUNCTION: Dual endothelin-1/angiotensin-2 receptor that is functionally
CC       coupled to a calcium-mobilizing transduction system, responding
CC       equivalently to both endothelin-1/EDN1 and angiotensin-2 v in a highly
CC       specific manner (PubMed:16293765). Also binds the signal peptide of
CC       VEGFA (PubMed:16293765). May play a role in angiogenesis with a
CC       significant role in cardiovascular and neural development
CC       (PubMed:16293765). {ECO:0000269|PubMed:16293765}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16293765};
CC       Single-pass membrane protein {ECO:0000250|UniProtKB:B0L3A2,
CC       ECO:0000255}.
CC   -!- TISSUE SPECIFICITY: Widely expressed with higher levels in kidney and
CC       aorta. {ECO:0000269|PubMed:16293765}.
CC   -!- DEVELOPMENTAL STAGE: At 9.5 dpc, expressed predominantly in the heart,
CC       yolk sac mesodermal layer and endothelium, fetal vascular endothelium
CC       in the placenta, dorsal aorta, and ependymal layer of the neural tube.
CC       Expression that persists at 12.5 dpc, where expression is increased in
CC       some hemangioblasts in yolk sac blood islands, as well as more
CC       prominent expression in the ependymal layer of the neuroepithelium and
CC       in perineural blood vessels. {ECO:0000269|PubMed:16293765}.
CC   -!- DISRUPTION PHENOTYPE: Embryonic lethal at 12.5 dpc. Mice exhibit
CC       impaired angiogenesis and dysregulated neuroepithelial development.
CC       {ECO:0000269|PubMed:16293765}.
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DR   EMBL; DQ009865; AAY56470.1; -; mRNA.
DR   EMBL; AC124496; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   MGI; MGI:3614654; Fbxw7as1.
DR   Proteomes; UP000000589; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IDA:MGI.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0004962; F:endothelin receptor activity; IDA:MGI.
DR   GO; GO:0038085; F:vascular endothelial growth factor binding; IDA:MGI.
DR   GO; GO:0005021; F:vascular endothelial growth factor receptor activity; IDA:MGI.
DR   GO; GO:0001568; P:blood vessel development; IMP:MGI.
DR   GO; GO:0021766; P:hippocampus development; IMP:MGI.
DR   GO; GO:0007611; P:learning or memory; IMP:MGI.
DR   GO; GO:0010506; P:regulation of autophagy; IMP:MGI.
PE   2: Evidence at transcript level;
KW   Cell membrane; Membrane; Receptor; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..127
FT                   /note="Dual endothelin-1/angiotensin II receptor"
FT                   /id="PRO_0000454051"
FT   TOPO_DOM        1..65
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000250|UniProtKB:B0L3A2"
FT   TRANSMEM        66..84
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        85..127
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250|UniProtKB:B0L3A2"
SQ   SEQUENCE   127 AA;  14117 MW;  489A7A26AC8C7B68 CRC64;
     MNALYVTTVP KGYSSLSKCN HNEQDTAYRL WLCTHNHWTA PSGMRLQPLT SLGSKEMKSR
     WNWGSITCII CFTCVGSQLS MSSSKASNFS GPLQLYQRGI GHITNSYKRP QAPAWPCLSS
     GTMGRSH