DEC11_DROME
ID DEC11_DROME Reviewed; 1208 AA.
AC P18169; Q8IRP1;
DT 01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT 16-MAY-2003, sequence version 2.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=Defective chorion-1 protein, FC125 isoform;
DE Flags: Precursor;
GN Name=dec-1; ORFNames=CG2175;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND ALTERNATIVE SPLICING.
RX PubMed=1699826; DOI=10.1016/0012-1606(90)90146-a;
RA Waring G.L., Hawley R.J., Schoenfeld T.;
RT "Multiple proteins are produced from the dec-1 eggshell gene in Drosophila
RT by alternative RNA splicing and proteolytic cleavage events.";
RL Dev. Biol. 142:1-12(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION, AND ALTERNATIVE SPLICING.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP FUNCTION, SUBCELLULAR LOCATION, AND DEVELOPMENTAL STAGE.
RX PubMed=3378704; DOI=10.1101/gad.2.3.341;
RA Hawley R.J., Waring G.L.;
RT "Cloning and analysis of the dec-1 female-sterile locus, a gene required
RT for proper assembly of the Drosophila eggshell.";
RL Genes Dev. 2:341-349(1988).
CC -!- FUNCTION: Required for proper assembly of the eggshell.
CC {ECO:0000269|PubMed:3378704}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:3378704}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=FC125;
CC IsoId=P18169-1; Sequence=Displayed;
CC Name=FC106;
CC IsoId=P18170-1; Sequence=External;
CC Name=FC177;
CC IsoId=P18171-1; Sequence=External;
CC -!- DEVELOPMENTAL STAGE: Expression peaks at embryonic stage 10A, is
CC slightly reduced by stage 10B, and undetected in stage 11.
CC {ECO:0000269|PubMed:3378704}.
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DR EMBL; M35887; AAA28446.1; -; mRNA.
DR EMBL; AE014298; AAN09215.1; -; Genomic_DNA.
DR PIR; A44766; A44766.
DR RefSeq; NP_727202.1; NM_167132.2. [P18169-1]
DR AlphaFoldDB; P18169; -.
DR BioGRID; 58165; 3.
DR IntAct; P18169; 5.
DR DNASU; 31691; -.
DR EnsemblMetazoa; FBtr0071146; FBpp0071098; FBgn0000427. [P18169-1]
DR GeneID; 31691; -.
DR CTD; 31691; -.
DR FlyBase; FBgn0000427; dec-1.
DR VEuPathDB; VectorBase:FBgn0000427; -.
DR SignaLink; P18169; -.
DR BioGRID-ORCS; 31691; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 31691; -.
DR Proteomes; UP000000803; Chromosome X.
DR Bgee; FBgn0000427; Expressed in adult abdomen and 11 other tissues.
DR ExpressionAtlas; P18169; baseline and differential.
DR Genevisible; P18169; DM.
DR GO; GO:0042600; C:egg chorion; IDA:UniProtKB.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000987; F:cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0005213; F:structural constituent of egg chorion; IMP:UniProtKB.
DR GO; GO:0007304; P:chorion-containing eggshell formation; IMP:FlyBase.
DR GO; GO:0007306; P:eggshell chorion assembly; IMP:UniProtKB.
DR GO; GO:0043619; P:regulation of transcription from RNA polymerase II promoter in response to oxidative stress; IBA:GO_Central.
DR GO; GO:0042594; P:response to starvation; IBA:GO_Central.
DR InterPro; IPR006720; DEC-1_C.
DR InterPro; IPR006719; DEC-1_N.
DR InterPro; IPR006718; DEC-1_REPEAT.
DR Pfam; PF04624; Dec-1; 8.
DR Pfam; PF04626; DEC-1_C; 1.
DR Pfam; PF04625; DEC-1_N; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome; Repeat; Secreted; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..1208
FT /note="Defective chorion-1 protein, FC125 isoform"
FT /id="PRO_0000021097"
FT REPEAT 493..518
FT /note="1"
FT REPEAT 519..544
FT /note="2"
FT REPEAT 545..570
FT /note="3"
FT REPEAT 571..596
FT /note="4"
FT REPEAT 597..622
FT /note="5"
FT REPEAT 623..652
FT /note="6; approximate"
FT REPEAT 653..680
FT /note="7; approximate"
FT REPEAT 681..696
FT /note="8; approximate"
FT REPEAT 697..720
FT /note="9; approximate"
FT REPEAT 721..733
FT /note="10; approximate"
FT REPEAT 734..758
FT /note="11; approximate"
FT REPEAT 759..788
FT /note="12; approximate"
FT REGION 23..60
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 184..212
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 268..294
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 493..788
FT /note="12 X 26 AA approximate tandem repeats, Glu, Met-
FT rich"
FT REGION 828..875
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 944..1010
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1114..1208
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 23..46
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 184..211
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 851..865
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 944..976
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 989..1008
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1127..1154
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1155..1175
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1176..1196
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 17
FT /note="A -> V (in Ref. 1; AAA28446)"
FT /evidence="ECO:0000305"
FT CONFLICT 219
FT /note="Q -> E (in Ref. 1; AAA28446)"
FT /evidence="ECO:0000305"
FT CONFLICT 347
FT /note="D -> H (in Ref. 1; AAA28446)"
FT /evidence="ECO:0000305"
FT CONFLICT 382
FT /note="A -> T (in Ref. 1; AAA28446)"
FT /evidence="ECO:0000305"
FT CONFLICT 847..877
FT /note="PENEGTARHKVDALGVGGNKRKKSKSKSAPP -> AGERRHRQAQSRCPGSW
FT RQQAQEVQVQVGAA (in Ref. 1; AAA28446)"
FT /evidence="ECO:0000305"
FT CONFLICT 888..901
FT /note="QRPVVQSYGTSYGG -> SVRWFRVTEQATAE (in Ref. 1)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1208 AA; 137444 MW; 2D8D140756FFFDEE CRC64;
MRLFSLLPLL ALLVVQAAGQ SEVTSDDPAT DAGSTTNSTT DTKPRIPSQD EILGQMPSIN
PIRTGNPQMD AFYMMFPALG SLLKWGSLFP AYSILGAIPD NLQPTAAASK VVLVLADDAT
AKTRVARQNP PPNPLGQLMN WPALPQDFQL PSMDLGPQVG SFLAQLPAMP TVPGLLGAAA
PVPAPAPAPA AAPPPAPAPA ADPPAAPVPD APQPAILGQA ALQNAFTFFN PANFDASSLL
GQSVPTFAPP NLDFVAQMQR QFFPGMTPAQ PAAAGTDAQA SDISEVRVRP EDPYSQEAQM
KIKSALEMEQ ERQQQAQVKD QEQVPLLWFR MPTTQNQDAT EEKTLEDLRV EAKLRAFERQ
VIAELRMLQK IELMAKQMRS SAAAQNGDSP YRISYPLSRT PIHKITRADI EQALRDDYVR
RLVNKEAQRR ARNSGINTQK ANALKRQAKS QDQTLSKEDI VQIMAYAYRM ANEQMESEKG
KQDKVYAAYR TEQNPMMMQQ RQWSEEQAKI QQNQQQIQQN PMMMQQRQWS EEQAKIQQNQ
QQIQQNPMMM QQRQWSEEQA KIQQNQQQIQ QNPMMMQQRQ WSEEQAKIQQ NQQQIQQNPM
MVQQRQWSEE QAKIQQNQQQ IQQNPMMMQQ RQWSEEQAKI QHDQQMAQQM AQQGLMMTEQ
RQRQWSEDQA KIQQAQQMAQ QTPMMMPQMQ QRQWTEDPQM VQQMQQRQWA EDQTRMQMAQ
QNPMMQQQRQ MAENPQMMQQ RQWSEEQTKI EQAQQMAQQN QMMMQQMQQR QWSEDQAQIQ
QQQRQMMQQT PMMMKERQWA EENPQSVQQQ GPMMMQQQMP SMMQREVEDE DNKAEDDLVG
EAGPQMPENE GTARHKVDAL GVGGNKRKKS KSKSAPPTVI NYYYAAPQRP VVQSYGTSYG
GGGYGSNAYG VPRPVNSYQS QGYRAAVGND EVDEMLRQHQ TMARTINPKQ PGEVGGSESQ
KSNSNPPTTL TPAPQEQPQE HRVHKSPSSA PSETEIENAP SSDPQVGSIF TYGEGLLHPF
MGLLPVERPD DPWNQKPYDP HHPLYTGGGS YDAYLRDGRH RRDTHIMGQG TQHGILTPGM
LERLLRIKMD FQRRFPHLYK GMLNHHTNLT RVEVQPPVLG KISKPKTKTK PKNEDEPVFE
LGAAERSLFE DETNDSLEKD PEPEPDEEDD RDVEEPSESS EPRGFSSKKS RDENDIDYFN
FDDDDVDD
