DEC13_DROME
ID DEC13_DROME Reviewed; 1590 AA.
AC P18171; Q9W3P3;
DT 01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT 16-MAY-2003, sequence version 2.
DT 03-AUG-2022, entry version 157.
DE RecName: Full=Defective chorion-1 protein, FC177 isoform;
DE Flags: Precursor;
GN Name=dec-1; ORFNames=CG2175;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND ALTERNATIVE SPLICING.
RX PubMed=1699826; DOI=10.1016/0012-1606(90)90146-a;
RA Waring G.L., Hawley R.J., Schoenfeld T.;
RT "Multiple proteins are produced from the dec-1 eggshell gene in Drosophila
RT by alternative RNA splicing and proteolytic cleavage events.";
RL Dev. Biol. 142:1-12(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION, AND ALTERNATIVE SPLICING.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP FUNCTION, SUBCELLULAR LOCATION, AND DEVELOPMENTAL STAGE.
RX PubMed=3378704; DOI=10.1101/gad.2.3.341;
RA Hawley R.J., Waring G.L.;
RT "Cloning and analysis of the dec-1 female-sterile locus, a gene required
RT for proper assembly of the Drosophila eggshell.";
RL Genes Dev. 2:341-349(1988).
CC -!- FUNCTION: Required for proper assembly of the eggshell.
CC {ECO:0000269|PubMed:3378704}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:3378704}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=FC177;
CC IsoId=P18171-1; Sequence=Displayed;
CC Name=FC106;
CC IsoId=P18170-1; Sequence=External;
CC Name=FC125;
CC IsoId=P18169-1; Sequence=External;
CC -!- DEVELOPMENTAL STAGE: Expressed during embryonic stage 11.
CC {ECO:0000269|PubMed:3378704}.
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DR EMBL; M35889; AAA28448.1; -; mRNA.
DR EMBL; AE014298; AAF46278.2; -; Genomic_DNA.
DR PIR; C44766; C44766.
DR RefSeq; NP_511072.2; NM_078517.3. [P18171-1]
DR AlphaFoldDB; P18171; -.
DR SMR; P18171; -.
DR BioGRID; 58165; 3.
DR DIP; DIP-19055N; -.
DR IntAct; P18171; 11.
DR STRING; 7227.FBpp0071097; -.
DR PaxDb; P18171; -.
DR PRIDE; P18171; -.
DR DNASU; 31691; -.
DR EnsemblMetazoa; FBtr0071145; FBpp0071097; FBgn0000427. [P18171-1]
DR GeneID; 31691; -.
DR KEGG; dme:Dmel_CG2175; -.
DR CTD; 31691; -.
DR FlyBase; FBgn0000427; dec-1.
DR VEuPathDB; VectorBase:FBgn0000427; -.
DR eggNOG; ENOG502QPW2; Eukaryota.
DR InParanoid; P18171; -.
DR PhylomeDB; P18171; -.
DR SignaLink; P18171; -.
DR BioGRID-ORCS; 31691; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 31691; -.
DR Proteomes; UP000000803; Chromosome X.
DR Bgee; FBgn0000427; Expressed in adult abdomen and 11 other tissues.
DR ExpressionAtlas; P18171; baseline and differential.
DR Genevisible; P18171; DM.
DR GO; GO:0042600; C:egg chorion; IDA:UniProtKB.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000987; F:cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0005213; F:structural constituent of egg chorion; IMP:UniProtKB.
DR GO; GO:0007304; P:chorion-containing eggshell formation; IMP:FlyBase.
DR GO; GO:0007306; P:eggshell chorion assembly; IMP:UniProtKB.
DR GO; GO:0043619; P:regulation of transcription from RNA polymerase II promoter in response to oxidative stress; IBA:GO_Central.
DR GO; GO:0042594; P:response to starvation; IBA:GO_Central.
DR InterPro; IPR006720; DEC-1_C.
DR InterPro; IPR006719; DEC-1_N.
DR InterPro; IPR006718; DEC-1_REPEAT.
DR Pfam; PF04624; Dec-1; 8.
DR Pfam; PF04626; DEC-1_C; 1.
DR Pfam; PF04625; DEC-1_N; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome; Repeat; Secreted; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..1590
FT /note="Defective chorion-1 protein, FC177 isoform"
FT /id="PRO_0000021101"
FT REPEAT 493..518
FT /note="1"
FT REPEAT 519..544
FT /note="2"
FT REPEAT 545..570
FT /note="3"
FT REPEAT 571..596
FT /note="4"
FT REPEAT 597..622
FT /note="5"
FT REPEAT 623..652
FT /note="6; approximate"
FT REPEAT 653..680
FT /note="7; approximate"
FT REPEAT 681..696
FT /note="8; approximate"
FT REPEAT 697..720
FT /note="9; approximate"
FT REPEAT 721..733
FT /note="10; approximate"
FT REPEAT 734..758
FT /note="11; approximate"
FT REPEAT 759..788
FT /note="12; approximate"
FT REGION 23..60
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 184..212
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 268..294
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 493..788
FT /note="12 X 26 AA approximate tandem repeats, Glu, Met-
FT rich"
FT REGION 843..875
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 944..983
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1119..1221
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1261..1352
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1375..1515
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1538..1590
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 23..46
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 184..211
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 851..865
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 944..976
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1127..1142
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1144..1199
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1270..1292
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1293..1308
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1309..1340
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1375..1393
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1423..1453
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1540..1556
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1559..1578
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 17
FT /note="A -> V (in Ref. 1; AAA28448)"
FT /evidence="ECO:0000305"
FT CONFLICT 219
FT /note="Q -> E (in Ref. 1; AAA28448)"
FT /evidence="ECO:0000305"
FT CONFLICT 347
FT /note="D -> H (in Ref. 1; AAA28448)"
FT /evidence="ECO:0000305"
FT CONFLICT 382
FT /note="A -> T (in Ref. 1; AAA28448)"
FT /evidence="ECO:0000305"
FT CONFLICT 847..877
FT /note="PENEGTARHKVDALGVGGNKRKKSKSKSAPP -> AGERRHRQAQSRCPGSW
FT RQQAQEVQVQVGAA (in Ref. 1; AAA28448)"
FT /evidence="ECO:0000305"
FT CONFLICT 888..901
FT /note="QRPVVQSYGTSYGG -> SVRWFRVTEQATAE (in Ref. 1)"
FT /evidence="ECO:0000305"
FT CONFLICT 995
FT /note="R -> Q (in Ref. 1; AAA28448)"
FT /evidence="ECO:0000305"
FT CONFLICT 1051..1052
FT /note="SV -> C (in Ref. 1; AAA28448)"
FT /evidence="ECO:0000305"
FT CONFLICT 1296
FT /note="Q -> P (in Ref. 1; AAA28448)"
FT /evidence="ECO:0000305"
FT CONFLICT 1299
FT /note="E -> D (in Ref. 1; AAA28448)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1590 AA; 179188 MW; F78F36B465D1D790 CRC64;
MRLFSLLPLL ALLVVQAAGQ SEVTSDDPAT DAGSTTNSTT DTKPRIPSQD EILGQMPSIN
PIRTGNPQMD AFYMMFPALG SLLKWGSLFP AYSILGAIPD NLQPTAAASK VVLVLADDAT
AKTRVARQNP PPNPLGQLMN WPALPQDFQL PSMDLGPQVG SFLAQLPAMP TVPGLLGAAA
PVPAPAPAPA AAPPPAPAPA ADPPAAPVPD APQPAILGQA ALQNAFTFFN PANFDASSLL
GQSVPTFAPP NLDFVAQMQR QFFPGMTPAQ PAAAGTDAQA SDISEVRVRP EDPYSQEAQM
KIKSALEMEQ ERQQQAQVKD QEQVPLLWFR MPTTQNQDAT EEKTLEDLRV EAKLRAFERQ
VIAELRMLQK IELMAKQMRS SAAAQNGDSP YRISYPLSRT PIHKITRADI EQALRDDYVR
RLVNKEAQRR ARNSGINTQK ANALKRQAKS QDQTLSKEDI VQIMAYAYRM ANEQMESEKG
KQDKVYAAYR TEQNPMMMQQ RQWSEEQAKI QQNQQQIQQN PMMMQQRQWS EEQAKIQQNQ
QQIQQNPMMM QQRQWSEEQA KIQQNQQQIQ QNPMMMQQRQ WSEEQAKIQQ NQQQIQQNPM
MVQQRQWSEE QAKIQQNQQQ IQQNPMMMQQ RQWSEEQAKI QHDQQMAQQM AQQGLMMTEQ
RQRQWSEDQA KIQQAQQMAQ QTPMMMPQMQ QRQWTEDPQM VQQMQQRQWA EDQTRMQMAQ
QNPMMQQQRQ MAENPQMMQQ RQWSEEQTKI EQAQQMAQQN QMMMQQMQQR QWSEDQAQIQ
QQQRQMMQQT PMMMKERQWA EENPQSVQQQ GPMMMQQQMP SMMQREVEDE DNKAEDDLVG
EAGPQMPENE GTARHKVDAL GVGGNKRKKS KSKSAPPTVI NYYYAAPQRP VVQSYGTSYG
GGGYGSNAYG VPRPVNSYQS QGYRAAVGND EVDEMLRQHQ TMARTINPKQ PGEVGGSESQ
KSNSNPPTTL TPAPQEQPQE HRVHKRLAHF HRFGREAGLN ATTSKGCGCG RLDCLCGRSC
RCGRRGLESR VVSSRTSGTC QCKASHRNKR SVEYGTLETI DEGSLNELRR EYKLGLKEIT
LSPDEDPAEA LMRYNAASIR EALERASMEP LEIGGDQYEE DAQQEPMEEE QLQHDPNTEP
QYNHKDFVRL TTSTASPITS TTEAATPTGS DSTSEATVTP EVTTTTSTST TTTTESTKDE
GLDMQQDSQA EAESSHVTKS ISKQEAEIHQ LHSIVEELKN EILKLNLRCS TIISNNVAKE
PVTEKNPPVV EEPSKQEDKP KVEEKVIAEE QAPVEQEEEL EEDEDSTSIS TTTETPSPSG
SYSTKPGLSL GSPRVDEQSG SSNKLDYDDD NNWQRILANR GYDTDYLTKS HERQFAQGQN
LEMPKNCNYD GNGSQEYGPY PEFQADEPST DTEGKAKRAL SVKQQAQLLN AALNDSGSDS
SDGTTTTTTP SPYAMRGKFV RRRSTARRVP IPKIGKASDE VWVRSPRQAK MPQRPKKSMS
KPKKQSSQVT TQATVSSTKL DSLVDVLKDL VRLQIQKEKK SSLLRTQSNN LSKTKPKSIK
PVKVIKRKRL RRRQHKSIAT TIRSPIQTKA
