DECA_DROPS
ID DECA_DROPS Reviewed; 616 AA.
AC P91699; Q29KY8; Q56RP3;
DT 15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT 16-DEC-2008, sequence version 3.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=Protein decapentaplegic;
DE Short=Protein DPP-C;
DE Flags: Precursor;
GN Name=dpp; ORFNames=GA22099;
OS Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=46245;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9071585; DOI=10.1093/genetics/145.2.297;
RA Newfeld S.J., Padgett R.W., Findley S.D., Richter B.G., Sanicola M.,
RA de Cuevas M., Gelbart W.M.;
RT "Molecular evolution at the decapentaplegic locus in Drosophila.";
RL Genetics 145:297-309(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MV2-25 / Tucson 14011-0121.94;
RX PubMed=15632085; DOI=10.1101/gr.3059305;
RA Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA Weinstock G.M., Gibbs R.A.;
RT "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT gene, and cis-element evolution.";
RL Genome Res. 15:1-18(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 10-333.
RX PubMed=15545653; DOI=10.1534/genetics.104.033068;
RA Bartolome C., Maside X., Yi S., Grant A.L., Charlesworth B.;
RT "Patterns of selection on synonymous and nonsynonymous variants in
RT Drosophila miranda.";
RL Genetics 169:1495-1507(2005).
CC -!- FUNCTION: Acts as an extracellular morphogen to establish at least two
CC cellular response thresholds within the dorsal half of the drosophila
CC embryo. Required for the proper development of the embryonic dorsal
CC hypoderm, for viability of larvae and for cell viability of the
CC epithelial cells in the imaginal disks. Acts together with scw (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Heterodimers of scw/dpp are the active subunit, dpp/dpp
CC homodimers elicit a basal response and scw/scw homodimers alone are
CC ineffective in specifying a dorsal pattern. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted. Note=Is internalized by receptor-
CC mediated endocytosis. {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed in the imaginal discs associated with
CC establishment of the proximal-distal axis of the appendages, and midgut
CC mesoderm.
CC -!- SIMILARITY: Belongs to the TGF-beta family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=EAL33036.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; U63856; AAC47553.1; -; Genomic_DNA.
DR EMBL; CH379061; EAL33036.2; ALT_SEQ; Genomic_DNA.
DR EMBL; AY754464; AAX13039.1; -; Genomic_DNA.
DR AlphaFoldDB; P91699; -.
DR SMR; P91699; -.
DR STRING; 7237.FBpp0287762; -.
DR PRIDE; P91699; -.
DR eggNOG; KOG3900; Eukaryota.
DR InParanoid; P91699; -.
DR Proteomes; UP000001819; Genome assembly.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0010033; P:response to organic substance; IEA:UniProt.
DR Gene3D; 2.10.90.10; -; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR001111; TGF-b_propeptide.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848; PTHR11848; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR Pfam; PF00688; TGFb_propeptide; 1.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; SSF57501; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; Differentiation; Disulfide bond; Glycoprotein;
KW Growth factor; Reference proteome; Secreted; Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT PROPEP 24..474
FT /evidence="ECO:0000250"
FT /id="PRO_0000033666"
FT CHAIN 475..616
FT /note="Protein decapentaplegic"
FT /id="PRO_0000033667"
FT REGION 80..188
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 470..512
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 80..107
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 112..138
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 166..188
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 147
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 360
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 395
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 557
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 515..581
FT /evidence="ECO:0000250"
FT DISULFID 544..613
FT /evidence="ECO:0000250"
FT DISULFID 548..615
FT /evidence="ECO:0000250"
FT DISULFID 580
FT /note="Interchain"
FT /evidence="ECO:0000250"
FT CONFLICT 45
FT /note="A -> AAAA (in Ref. 3; AAX13039)"
FT /evidence="ECO:0000305"
FT CONFLICT 54
FT /note="T -> TAT (in Ref. 1; AAC47553 and 3; AAX13039)"
FT /evidence="ECO:0000305"
FT CONFLICT 95..96
FT /note="Missing (in Ref. 3; AAX13039)"
FT /evidence="ECO:0000305"
FT CONFLICT 163
FT /note="Q -> QQQQ (in Ref. 1; AAC47553)"
FT /evidence="ECO:0000305"
FT CONFLICT 179
FT /note="T -> A (in Ref. 1; AAC47553)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 616 AA; 68512 MW; 413349FE288F48B8 CRC64;
MRAWILLLAV LATSQPIVQV ASTEDTSISQ RFIAAIAPTR TEPSAASAAA AAATATATAT
ATTALAKAFN PFNELLYKSS DSDSDNNNNN YKNRNNNNNN LNKGPRNNKN KGNKHSKSDA
NRQFNEVHKP RTDQLENSKN KPKQLVNKTN KMAVKDQKHH QPQQQQQQHH KPATTTALTS
TESHQSPIET IFVDDPALAL EEEVASINVP ANAGAIIEEQ EPSTYSKKEL IKDKLKPDPS
TLVEIENSLL SLFNMKRPPK IDRSKIIIPE AMKKLYAEIM GHELDSVNIP RPGLLTKSAN
TVRSFTHKDS KIDDRFPHHH RFRLHFDVKS IPAEEKLKAA ELQLTRDALA QAAVASTSAN
RTRYQVLVYD ITRVGVRGQR EPSYLLLDTK TVRLNSTDTV SLDVQPAVDR WLATPQKNYG
LLVEVRTMRS LKPAPHHHVR LRRSADEAHE QWQHKQPLLF AYTDDGRHKA RSIRDVSGGG
GGGGGAGEGG KGNGGGRNRR HQRRPARRKN HEETCRRHSL YVDFADVGWD DWIVAPPGYD
AYYCHGKCPF PLADHFNSTN HAVVQTLVNN LNPGKVPKAC CVPTQLDSVA MLYLNDQSTV
VLKNYQEMTV VGCGCR
