DECA_DROSI
ID DECA_DROSI Reviewed; 593 AA.
AC P91706;
DT 15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1997, sequence version 1.
DT 25-MAY-2022, entry version 93.
DE RecName: Full=Protein decapentaplegic;
DE Short=Protein DPP-C;
DE Flags: Precursor;
GN Name=dpp;
OS Drosophila simulans (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7240;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=NET DP1;
RX PubMed=9071585; DOI=10.1093/genetics/145.2.297;
RA Newfeld S.J., Padgett R.W., Findley S.D., Richter B.G., Sanicola M.,
RA de Cuevas M., Gelbart W.M.;
RT "Molecular evolution at the decapentaplegic locus in Drosophila.";
RL Genetics 145:297-309(1997).
CC -!- FUNCTION: Acts as an extracellular morphogen to establish at least two
CC cellular response thresholds within the dorsal half of the drosophila
CC embryo. Required for the proper development of the embryonic dorsal
CC hypoderm, for viability of larvae and for cell viability of the
CC epithelial cells in the imaginal disks. Acts together with scw (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Heterodimers of scw/dpp are the active subunit, dpp/dpp
CC homodimers elicit a basal response and scw/scw homodimers alone are
CC ineffective in specifying a dorsal pattern. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted. Note=Is internalized by receptor-
CC mediated endocytosis. {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed in the imaginal discs associated with
CC establishment of the proximal-distal axis of the appendages, and midgut
CC mesoderm.
CC -!- SIMILARITY: Belongs to the TGF-beta family. {ECO:0000305}.
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DR EMBL; U63854; AAC47554.1; -; Genomic_DNA.
DR AlphaFoldDB; P91706; -.
DR SMR; P91706; -.
DR GO; GO:0031252; C:cell leading edge; IEA:EnsemblMetazoa.
DR GO; GO:0035230; C:cytoneme; IEA:EnsemblMetazoa.
DR GO; GO:0098898; C:dense core granule lumen; IEA:EnsemblMetazoa.
DR GO; GO:0005615; C:extracellular space; IEA:EnsemblMetazoa.
DR GO; GO:0070700; F:BMP receptor binding; IEA:EnsemblMetazoa.
DR GO; GO:0005518; F:collagen binding; IEA:EnsemblMetazoa.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0008201; F:heparin binding; IEA:EnsemblMetazoa.
DR GO; GO:0016015; F:morphogen activity; IEA:EnsemblMetazoa.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:EnsemblMetazoa.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:EnsemblMetazoa.
DR GO; GO:0007378; P:amnioserosa formation; IEA:EnsemblMetazoa.
DR GO; GO:0061327; P:anterior Malpighian tubule development; IEA:EnsemblMetazoa.
DR GO; GO:0030509; P:BMP signaling pathway; IEA:EnsemblMetazoa.
DR GO; GO:0010002; P:cardioblast differentiation; IEA:EnsemblMetazoa.
DR GO; GO:0061352; P:cell chemotaxis involved in Malpighian tubule morphogenesis; IEA:EnsemblMetazoa.
DR GO; GO:0046843; P:dorsal appendage formation; IEA:EnsemblMetazoa.
DR GO; GO:0007391; P:dorsal closure; IEA:EnsemblMetazoa.
DR GO; GO:0001715; P:ectodermal cell fate specification; IEA:EnsemblMetazoa.
DR GO; GO:0007427; P:epithelial cell migration, open tracheal system; IEA:EnsemblMetazoa.
DR GO; GO:0007455; P:eye-antennal disc morphogenesis; IEA:EnsemblMetazoa.
DR GO; GO:0036099; P:female germ-line stem cell population maintenance; IEA:EnsemblMetazoa.
DR GO; GO:0035156; P:fusion cell fate specification; IEA:EnsemblMetazoa.
DR GO; GO:0035224; P:genital disc anterior/posterior pattern formation; IEA:EnsemblMetazoa.
DR GO; GO:0035263; P:genital disc sexually dimorphic development; IEA:EnsemblMetazoa.
DR GO; GO:0008354; P:germ cell migration; IEA:EnsemblMetazoa.
DR GO; GO:0042078; P:germ-line stem cell division; IEA:EnsemblMetazoa.
DR GO; GO:0060323; P:head morphogenesis; IEA:EnsemblMetazoa.
DR GO; GO:0007516; P:hemocyte development; IEA:EnsemblMetazoa.
DR GO; GO:0008586; P:imaginal disc-derived wing vein morphogenesis; IEA:EnsemblMetazoa.
DR GO; GO:0007474; P:imaginal disc-derived wing vein specification; IEA:EnsemblMetazoa.
DR GO; GO:0035217; P:labial disc development; IEA:EnsemblMetazoa.
DR GO; GO:0035168; P:larval lymph gland hemocyte differentiation; IEA:EnsemblMetazoa.
DR GO; GO:0036098; P:male germ-line stem cell population maintenance; IEA:EnsemblMetazoa.
DR GO; GO:0007313; P:maternal specification of dorsal/ventral axis, oocyte, soma encoded; IEA:EnsemblMetazoa.
DR GO; GO:0007498; P:mesoderm development; IEA:EnsemblMetazoa.
DR GO; GO:0010629; P:negative regulation of gene expression; IEA:EnsemblMetazoa.
DR GO; GO:0061320; P:pericardial nephrocyte differentiation; IEA:EnsemblMetazoa.
DR GO; GO:0010628; P:positive regulation of gene expression; IEA:EnsemblMetazoa.
DR GO; GO:0045572; P:positive regulation of imaginal disc growth; IEA:EnsemblMetazoa.
DR GO; GO:0048636; P:positive regulation of muscle organ development; IEA:EnsemblMetazoa.
DR GO; GO:0060391; P:positive regulation of SMAD protein signal transduction; IEA:EnsemblMetazoa.
DR GO; GO:0007458; P:progression of morphogenetic furrow involved in compound eye morphogenesis; IEA:EnsemblMetazoa.
DR GO; GO:0045464; P:R8 cell fate specification; IEA:EnsemblMetazoa.
DR GO; GO:2000736; P:regulation of stem cell differentiation; IEA:EnsemblMetazoa.
DR GO; GO:0035158; P:regulation of tube diameter, open tracheal system; IEA:EnsemblMetazoa.
DR GO; GO:0030721; P:spectrosome organization; IEA:EnsemblMetazoa.
DR GO; GO:0035309; P:wing and notum subfield formation; IEA:EnsemblMetazoa.
DR GO; GO:0035222; P:wing disc pattern formation; IEA:EnsemblMetazoa.
DR GO; GO:0007352; P:zygotic specification of dorsal/ventral axis; IEA:EnsemblMetazoa.
DR Gene3D; 2.10.90.10; -; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR001111; TGF-b_propeptide.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848; PTHR11848; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR Pfam; PF00688; TGFb_propeptide; 1.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; SSF57501; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; Differentiation; Disulfide bond; Glycoprotein;
KW Growth factor; Secreted; Signal.
FT SIGNAL 1..15
FT /evidence="ECO:0000255"
FT PROPEP 16..461
FT /evidence="ECO:0000250"
FT /id="PRO_0000033668"
FT CHAIN 462..593
FT /note="Protein decapentaplegic"
FT /id="PRO_0000033669"
FT REGION 45..174
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 459..489
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 49..82
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 83..108
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 109..135
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 142..159
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 122
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 347
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 382
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 534
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 492..558
FT /evidence="ECO:0000250"
FT DISULFID 521..590
FT /evidence="ECO:0000250"
FT DISULFID 525..592
FT /evidence="ECO:0000250"
FT DISULFID 557
FT /note="Interchain"
FT /evidence="ECO:0000250"
SQ SEQUENCE 593 AA; 66248 MW; F0BDB21209F44380 CRC64;
MRAWLLLLAV LATFQTIVRV ASTEDISQRF IAAIAPVAAE IPLASASGSG SGPGRSGSRS
GGASTSTALA KAFNPFSEPA SFSDSDKSHR SKTNKKPSKS DANRQFNEVH KPRTGQLENS
KNKSKQLVNK PNHNNHNKMA VKEQRSHHKK SHHHRSHQPK QASASTESHQ SSSIESIFVE
EPTLVLDREV ASINVPANAK AIIAEQGPST YSKEALIKDK LKPDPSTLVE IEKSLLSLFN
MKRPPKIDRS KIIIPEPMKK LYAEIMGHEL DSVNIPKPGL LTKSANTVRS FTHKDSKIDD
RFPHHHRFRL HFDVKSIPAD EKLKAAELQL TRDALSPQVV ASRSSANRTR YQVLVYDITR
VGVRGQREPS YLLLDTKTVR LNSTDTVSLD VQPAVDRWLA SPQRNYGLLV EVRTVRSLKP
APHHHVRLRR SADEAHERWQ HKQPLLFTYT DDGRHKARSI RDVSGGEGGG KGGRNKRQPR
RPTRRKNHDD TCRRHSLYVD FSDVGWDDWI VAPLGYDAYY CHGKCPFPLA DHFNSTNHAV
VQTLVNNMNP GKVPKACCVP TQLDSVAMLY LNDQSTVVLK NYQEMTVVGC GCR
