ID   DECO_MACDE              Reviewed;          39 AA.
AC   P17350;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1990, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Decorsin;
OS   Macrobdella decora (North American leech).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC   Hirudinea; Hirudinida; Hirudiniformes; Hirudinidae; Macrobdella.
OX   NCBI_TaxID=6405;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=2351655; DOI=10.1016/s0021-9258(19)38791-5;
RA   Seymour J.L., Henzel W.J., Nevins B., Stults J.T., Lazarus R.A.;
RT   "Decorsin. A potent glycoprotein IIb-IIIa antagonist and platelet
RT   aggregation inhibitor from the leech Macrobdella decora.";
RL   J. Biol. Chem. 265:10143-10147(1990).
RN   [2]
RP   STRUCTURE BY NMR.
RX   PubMed=8009227; DOI=10.1126/science.8009227;
RA   Krezel A.M., Wagner G., Seymour-Ulmer J., Lazarus R.A.;
RT   "Structure of the RGD protein decorsin: conserved motif and distinct
RT   function in leech proteins that affect blood clotting.";
RL   Science 264:1944-1947(1994).
CC   -!- FUNCTION: Inhibits fibrinogen interaction with platelet receptors
CC       expressed on glycoprotein IIb-IIIa complex. May prevent blood from
CC       clotting during either feeding and/or storage of ingested blood.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the ornatin family. {ECO:0000305}.
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DR   PIR; A36453; A36453.
DR   PDB; 1DEC; NMR; -; A=1-39.
DR   PDBsum; 1DEC; -.
DR   AlphaFoldDB; P17350; -.
DR   SMR; P17350; -.
DR   EvolutionaryTrace; P17350; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0004857; F:enzyme inhibitor activity; IEA:InterPro.
DR   GO; GO:0007596; P:blood coagulation; IEA:UniProtKB-KW.
DR   GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR   InterPro; IPR011061; Hirudin/antistatin.
DR   SUPFAM; SSF57262; SSF57262; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Blood coagulation; Cell adhesion; Direct protein sequencing;
KW   Hemostasis; Secreted.
FT   PEPTIDE         1..39
FT                   /note="Decorsin"
FT                   /id="PRO_0000044770"
FT   REGION          27..38
FT                   /note="High affinity binding domain"
FT                   /evidence="ECO:0000255"
FT   MOTIF           31..33
FT                   /note="Cell attachment site"
FT   VARIANT         1..3
FT                   /note="Missing (in N-3 isoform)"
FT   STRAND          15..22
FT                   /evidence="ECO:0007829|PDB:1DEC"
FT   STRAND          31..33
FT                   /evidence="ECO:0007829|PDB:1DEC"
SQ   SEQUENCE   39 AA;  4384 MW;  3A3B35756FB70D36 CRC64;
     APRLPQCQGD DQEKCLCNKD ECPPGQCRFP RGDADPYCE