DEDA_ECOLI
ID DEDA_ECOLI Reviewed; 219 AA.
AC P0ABP6; P09548;
DT 08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 08-NOV-2005, sequence version 1.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Protein DedA;
DE AltName: Full=Protein DSG-1;
GN Name=dedA; OrderedLocusNames=b2317, JW2314;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=K12;
RX PubMed=3040734; DOI=10.1016/s0021-9258(18)45338-0;
RA Nonet M.L., Marvel C.C., Tolan D.R.;
RT "The hisT-purF region of the Escherichia coli K-12 chromosome.
RT Identification of additional genes of the hisT and purF operons.";
RL J. Biol. Chem. 262:12209-12217(1987).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=9205837; DOI=10.1093/dnares/4.2.91;
RA Yamamoto Y., Aiba H., Baba T., Hayashi K., Inada T., Isono K., Itoh T.,
RA Kimura S., Kitagawa M., Makino K., Miki T., Mitsuhashi N., Mizobuchi K.,
RA Mori H., Nakade S., Nakamura Y., Nashimoto H., Oshima T., Oyama S.,
RA Saito N., Sampei G., Satoh Y., Sivasundaram S., Tagami H., Takahashi H.,
RA Takeda J., Takemoto K., Uehara K., Wada C., Yamagata S., Horiuchi T.;
RT "Construction of a contiguous 874-kb sequence of the Escherichia coli-K12
RT genome corresponding to 50.0-68.8 min on the linkage map and analysis of
RT its sequence features.";
RL DNA Res. 4:91-113(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-9.
RC STRAIN=K12;
RX PubMed=3029016; DOI=10.1128/jb.169.3.1061-1070.1987;
RA Arps P.J., Winkler M.E.;
RT "Structural analysis of the Escherichia coli K-12 hisT operon by using a
RT kanamycin resistance cassette.";
RL J. Bacteriol. 169:1061-1070(1987).
RN [6]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 204-219.
RX PubMed=7678242; DOI=10.1128/jb.175.2.332-340.1993;
RA Li S.-J., Cronan J.E. Jr.;
RT "Growth rate regulation of Escherichia coli acetyl coenzyme A carboxylase,
RT which catalyzes the first committed step of lipid biosynthesis.";
RL J. Bacteriol. 175:332-340(1993).
RN [7]
RP TOPOLOGY [LARGE SCALE ANALYSIS].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=15919996; DOI=10.1126/science.1109730;
RA Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.;
RT "Global topology analysis of the Escherichia coli inner membrane
RT proteome.";
RL Science 308:1321-1323(2005).
CC -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the DedA family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; M68934; AAA23964.1; -; Genomic_DNA.
DR EMBL; U00096; AAC75377.1; -; Genomic_DNA.
DR EMBL; AP009048; BAA16174.1; -; Genomic_DNA.
DR EMBL; M15543; AAA24314.1; -; Genomic_DNA.
DR EMBL; X02743; CAA26523.1; -; Genomic_DNA.
DR EMBL; S53037; AAB24893.1; -; mRNA.
DR PIR; B29803; XMECAD.
DR RefSeq; NP_416820.1; NC_000913.3.
DR RefSeq; WP_000364335.1; NZ_LN832404.1.
DR AlphaFoldDB; P0ABP6; -.
DR BioGRID; 4261363; 9.
DR DIP; DIP-48027N; -.
DR IntAct; P0ABP6; 1.
DR STRING; 511145.b2317; -.
DR TCDB; 9.B.27.2.3; the death effector domain a (deda) family.
DR jPOST; P0ABP6; -.
DR PaxDb; P0ABP6; -.
DR PRIDE; P0ABP6; -.
DR EnsemblBacteria; AAC75377; AAC75377; b2317.
DR EnsemblBacteria; BAA16174; BAA16174; BAA16174.
DR GeneID; 67416747; -.
DR GeneID; 946798; -.
DR KEGG; ecj:JW2314; -.
DR KEGG; eco:b2317; -.
DR PATRIC; fig|1411691.4.peg.4417; -.
DR EchoBASE; EB0212; -.
DR eggNOG; COG0586; Bacteria.
DR HOGENOM; CLU_044208_6_1_6; -.
DR InParanoid; P0ABP6; -.
DR OMA; PWYGIGR; -.
DR PhylomeDB; P0ABP6; -.
DR BioCyc; EcoCyc:EG10216-MON; -.
DR PRO; PR:P0ABP6; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IDA:EcoCyc.
DR InterPro; IPR032818; DedA.
DR InterPro; IPR032816; SNARE_assoc.
DR PANTHER; PTHR30353; PTHR30353; 1.
DR Pfam; PF09335; SNARE_assoc; 1.
PE 1: Evidence at protein level;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..219
FT /note="Protein DedA"
FT /id="PRO_0000161406"
FT TOPO_DOM 1..24
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 25..45
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 46..66
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 67..72
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 73..93
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 94..160
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 161..181
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 182..187
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 188..208
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 209..219
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 219 AA; 24510 MW; 37F38ABAB8678C20 CRC64;
MDLIYFLIDF ILHIDVHLAE LVAEYGVWVY AILFLILFCE TGLVVTPFLP GDSLLFVAGA
LASLETNDLN VHMMVVLMLI AAIVGDAVNY TIGRLFGEKL FSNPNSKIFR RSYLDKTHQF
YEKHGGKTII LARFVPIVRT FAPFVAGMGH MSYRHFAAYN VIGALLWVLL FTYAGYFFGT
IPMVQDNLKL LIVGIIVVSI LPGVIEIIRH KRAAARAAK
