DEF06_ARATH
ID DEF06_ARATH Reviewed; 73 AA.
AC Q9FFP8; P82783;
DT 13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Defensin-like protein 6;
DE AltName: Full=Low-molecular-weight cysteine-rich protein 74;
DE Short=Protein LCR74;
DE AltName: Full=Plant defensin 2.5;
DE Flags: Precursor;
GN Name=PDF2.5; Synonyms=LCR74; OrderedLocusNames=At5g63660; ORFNames=MBK5.14;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9330910; DOI=10.1093/dnares/4.3.215;
RA Sato S., Kotani H., Nakamura Y., Kaneko T., Asamizu E., Fukami M.,
RA Miyajima N., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. I. Sequence
RT features of the 1.6 Mb regions covered by twenty physically assigned P1
RT clones.";
RL DNA Res. 4:215-230(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP IDENTIFICATION.
RX PubMed=11437247; DOI=10.1023/a:1010664704926;
RA Vanoosthuyse V., Miege C., Dumas C., Cock J.M.;
RT "Two large Arabidopsis thaliana gene families are homologous to the
RT Brassica gene superfamily that encodes pollen coat proteins and the male
RT component of the self-incompatibility response.";
RL Plant Mol. Biol. 46:17-34(2001).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=12447532; DOI=10.1007/s00425-002-0902-6;
RA Thomma B.P.H.J., Cammue B.P., Thevissen K.;
RT "Plant defensins.";
RL Planta 216:193-202(2002).
RN [5]
RP GENE FAMILY.
RX PubMed=15955924; DOI=10.1104/pp.105.060079;
RA Silverstein K.A.T., Graham M.A., Paape T.D., VandenBosch K.A.;
RT "Genome organization of more than 300 defensin-like genes in Arabidopsis.";
RL Plant Physiol. 138:600-610(2005).
CC -!- FUNCTION: Confers broad-spectrum resistance to pathogens.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the DEFL family. {ECO:0000305}.
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DR EMBL; AB005234; BAB10459.1; -; Genomic_DNA.
DR EMBL; CP002688; AED97782.1; -; Genomic_DNA.
DR RefSeq; NP_201171.1; NM_125761.2.
DR AlphaFoldDB; Q9FFP8; -.
DR SMR; Q9FFP8; -.
DR STRING; 3702.AT5G63660.1; -.
DR PaxDb; Q9FFP8; -.
DR PRIDE; Q9FFP8; -.
DR ProteomicsDB; 224591; -.
DR EnsemblPlants; AT5G63660.1; AT5G63660.1; AT5G63660.
DR GeneID; 836486; -.
DR Gramene; AT5G63660.1; AT5G63660.1; AT5G63660.
DR KEGG; ath:AT5G63660; -.
DR Araport; AT5G63660; -.
DR TAIR; locus:2160569; AT5G63660.
DR eggNOG; ENOG502S7BC; Eukaryota.
DR HOGENOM; CLU_161668_1_2_1; -.
DR InParanoid; Q9FFP8; -.
DR OMA; HRRCYCT; -.
DR OrthoDB; 1625543at2759; -.
DR PhylomeDB; Q9FFP8; -.
DR PRO; PR:Q9FFP8; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9FFP8; baseline and differential.
DR Genevisible; Q9FFP8; AT.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0006952; P:defense response; ISS:TAIR.
DR GO; GO:0050832; P:defense response to fungus; IEA:UniProtKB-KW.
DR GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
DR CDD; cd00107; Knot1; 1.
DR Gene3D; 3.30.30.10; -; 1.
DR InterPro; IPR008176; Defensin_plant.
DR InterPro; IPR003614; Scorpion_toxin-like.
DR InterPro; IPR036574; Scorpion_toxin-like_sf.
DR PRINTS; PR00288; PUROTHIONIN.
DR SMART; SM00505; Knot1; 1.
DR SUPFAM; SSF57095; SSF57095; 1.
PE 3: Inferred from homology;
KW Antimicrobial; Disulfide bond; Fungicide; Plant defense;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..26
FT /evidence="ECO:0000255"
FT CHAIN 27..73
FT /note="Defensin-like protein 6"
FT /id="PRO_0000007028"
FT DISULFID 29..73
FT /evidence="ECO:0000250"
FT DISULFID 40..60
FT /evidence="ECO:0000250"
FT DISULFID 46..67
FT /evidence="ECO:0000250"
FT DISULFID 50..69
FT /evidence="ECO:0000250"
SQ SEQUENCE 73 AA; 8388 MW; 161507EA9C2A7509 CRC64;
MENKFFAAFF LLLVLFSSQE IIGGEGRTCQ SKSHHFKYMC TSNHNCAIVC RNEGFSGGRC
HGFHRRCYCT RLC
