DEF18_ARATH
ID DEF18_ARATH Reviewed; 80 AA.
AC Q9FZ31;
DT 28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 97.
DE RecName: Full=Defensin-like protein 18;
DE AltName: Full=Cysteine-rich antifungal protein At1g55010;
DE AltName: Full=Plant defensin 1.5;
DE Flags: Precursor;
GN Name=PDF1.5; OrderedLocusNames=At1g55010; ORFNames=F14C21.57, T24C10.12;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=12447532; DOI=10.1007/s00425-002-0902-6;
RA Thomma B.P.H.J., Cammue B.P., Thevissen K.;
RT "Plant defensins.";
RL Planta 216:193-202(2002).
RN [4]
RP GENE FAMILY.
RX PubMed=15955924; DOI=10.1104/pp.105.060079;
RA Silverstein K.A.T., Graham M.A., Paape T.D., VandenBosch K.A.;
RT "Genome organization of more than 300 defensin-like genes in Arabidopsis.";
RL Plant Physiol. 138:600-610(2005).
CC -!- FUNCTION: Confers broad-spectrum resistance to pathogens.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the DEFL family. {ECO:0000305}.
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DR EMBL; AC064840; AAG00880.1; -; Genomic_DNA.
DR EMBL; AC069144; AAG51104.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE33174.1; -; Genomic_DNA.
DR PIR; F96591; F96591.
DR RefSeq; NP_175899.1; NM_104375.2.
DR AlphaFoldDB; Q9FZ31; -.
DR SMR; Q9FZ31; -.
DR STRING; 3702.AT1G55010.1; -.
DR PaxDb; Q9FZ31; -.
DR PRIDE; Q9FZ31; -.
DR EnsemblPlants; AT1G55010.1; AT1G55010.1; AT1G55010.
DR GeneID; 841943; -.
DR Gramene; AT1G55010.1; AT1G55010.1; AT1G55010.
DR KEGG; ath:AT1G55010; -.
DR Araport; AT1G55010; -.
DR TAIR; locus:2011055; AT1G55010.
DR HOGENOM; CLU_161668_3_0_1; -.
DR InParanoid; Q9FZ31; -.
DR OrthoDB; 1565340at2759; -.
DR PhylomeDB; Q9FZ31; -.
DR PRO; PR:Q9FZ31; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9FZ31; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IDA:TAIR.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0009505; C:plant-type cell wall; IDA:TAIR.
DR GO; GO:0006875; P:cellular metal ion homeostasis; IMP:TAIR.
DR GO; GO:0006952; P:defense response; ISS:TAIR.
DR GO; GO:0050832; P:defense response to fungus; IEA:UniProtKB-KW.
DR GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
DR Gene3D; 3.30.30.10; -; 1.
DR InterPro; IPR036574; Scorpion_toxin-like_sf.
DR SUPFAM; SSF57095; SSF57095; 1.
PE 2: Evidence at transcript level;
KW Antimicrobial; Disulfide bond; Fungicide; Plant defense;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..29
FT /evidence="ECO:0000255"
FT CHAIN 30..80
FT /note="Defensin-like protein 18"
FT /id="PRO_0000379601"
FT DISULFID 32..80
FT /evidence="ECO:0000250"
FT DISULFID 43..64
FT /evidence="ECO:0000250"
FT DISULFID 49..74
FT /evidence="ECO:0000250"
FT DISULFID 53..76
FT /evidence="ECO:0000250"
SQ SEQUENCE 80 AA; 9139 MW; 8EFBF4ACA7974071 CRC64;
MAKFCTTITL ILVALVLFAD FEAPTIVKAE LCKRESETWS GRCVNDYQCR DHCINNDRGN
DGYCAGGYPW YRSCFCFFSC
