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DEF1A_CAVPO
ID   DEF1A_CAVPO             Reviewed;          93 AA.
AC   P11478;
DT   01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1993, sequence version 2.
DT   03-AUG-2022, entry version 127.
DE   RecName: Full=Neutrophil cationic peptide 1 type A;
DE   AltName: Full=GNCP-1A;
DE   Contains:
DE     RecName: Full=Neutrophil cationic peptide 1;
DE     AltName: Full=Corticostatic peptide GP-CS1;
DE              Short=CP-1;
DE     AltName: Full=GPNP;
DE     AltName: Full=Neutrophil defensin;
DE   Flags: Precursor;
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC   Cavia.
OX   NCBI_TaxID=10141;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Hartley; TISSUE=Bone marrow;
RX   PubMed=2013325; DOI=10.1016/0014-5793(91)80314-s;
RA   Nagaoka I., Someya A., Iwabuchi K., Yamashita T.;
RT   "Characterization of cDNA clones encoding guinea pig neutrophil cationic
RT   peptides.";
RL   FEBS Lett. 280:287-291(1991).
RN   [2]
RP   PROTEIN SEQUENCE OF 63-93.
RC   TISSUE=Peritoneal neutrophil;
RX   PubMed=3623703; DOI=10.1128/iai.55.9.2281-2286.1987;
RA   Selsted M.E., Harwig S.S.L.;
RT   "Purification, primary structure, and antimicrobial activities of a guinea
RT   pig neutrophil defensin.";
RL   Infect. Immun. 55:2281-2286(1987).
RN   [3]
RP   PROTEIN SEQUENCE OF 63-93.
RC   TISSUE=Bone marrow;
RX   PubMed=1659400; DOI=10.1016/s0006-291x(05)81101-5;
RA   Hu J., Bennett H.P.J., Lazure C., Solomon S.;
RT   "Isolation and characterization of corticostatic peptides from guinea pig
RT   bone marrow.";
RL   Biochem. Biophys. Res. Commun. 180:558-565(1991).
RN   [4]
RP   PROTEIN SEQUENCE OF 63-93.
RC   TISSUE=Neutrophil;
RX   PubMed=2473036; DOI=10.1128/iai.57.8.2405-2409.1989;
RA   Yamashita T., Saito K.;
RT   "Purification, primary structure, and biological activity of guinea pig
RT   neutrophil cationic peptides.";
RL   Infect. Immun. 57:2405-2409(1989).
CC   -!- FUNCTION: Has antibiotic, anti-fungi and antiviral activity.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the alpha-defensin family. {ECO:0000305}.
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DR   EMBL; D14119; BAA03182.1; -; Genomic_DNA.
DR   EMBL; X57705; CAA40880.1; ALT_SEQ; mRNA.
DR   EMBL; D37971; BAA07189.1; -; Genomic_DNA.
DR   PIR; S14314; S14314.
DR   AlphaFoldDB; P11478; -.
DR   SMR; P11478; -.
DR   TCDB; 1.C.19.1.3; the defensin (defensin) family.
DR   Ensembl; ENSCPOT00000000426; ENSCPOP00000014806; ENSCPOG00000000422.
DR   GeneTree; ENSGT01030000240119; -.
DR   HOGENOM; CLU_160803_0_0_1; -.
DR   InParanoid; P11478; -.
DR   OMA; SCHFLER; -.
DR   Proteomes; UP000005447; Unassembled WGS sequence.
DR   Bgee; ENSCPOG00000000422; Expressed in heart left ventricle and 4 other tissues.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0050832; P:defense response to fungus; IEA:UniProtKB-KW.
DR   GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR   GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
DR   InterPro; IPR016327; Alpha-defensin.
DR   InterPro; IPR006081; Alpha-defensin_C.
DR   InterPro; IPR002366; Alpha-defensin_propep.
DR   InterPro; IPR006080; Defensin_beta/alpha.
DR   PANTHER; PTHR11876; PTHR11876; 1.
DR   Pfam; PF00323; Defensin_1; 1.
DR   Pfam; PF00879; Defensin_propep; 1.
DR   PIRSF; PIRSF001875; Alpha-defensin; 1.
DR   SMART; SM00048; DEFSN; 1.
DR   PROSITE; PS00269; DEFENSIN; 1.
PE   1: Evidence at protein level;
KW   Antibiotic; Antimicrobial; Antiviral defense; Defensin;
KW   Direct protein sequencing; Disulfide bond; Fungicide; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   PROPEP          20..62
FT                   /evidence="ECO:0000269|PubMed:1659400,
FT                   ECO:0000269|PubMed:2473036, ECO:0000269|PubMed:3623703"
FT                   /id="PRO_0000006765"
FT   PEPTIDE         63..93
FT                   /note="Neutrophil cationic peptide 1"
FT                   /id="PRO_0000006766"
FT   DISULFID        65..93
FT                   /evidence="ECO:0000250"
FT   DISULFID        67..82
FT                   /evidence="ECO:0000250"
FT   DISULFID        72..92
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   93 AA;  10479 MW;  D85EAC5A1EBEA4B3 CRC64;
     MRTVPLFAAC LLLTLMAQAE PLPRAADHSD TKMKGDREDH VAVISFWEEE STSLEDAGAG
     AGRRCICTTR TCRFPYRRLG TCIFQNRVYT FCC
 
 
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