DEF1B_CAVPO
ID DEF1B_CAVPO Reviewed; 93 AA.
AC Q64365;
DT 14-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 88.
DE RecName: Full=Neutrophil cationic peptide 1 type B;
DE AltName: Full=GNCP-1B;
DE Contains:
DE RecName: Full=Neutrophil cationic peptide 1;
DE AltName: Full=Corticostatic peptide GP-CS1;
DE Short=CP-1;
DE AltName: Full=GPNP;
DE AltName: Full=Neutrophil defensin;
DE Flags: Precursor;
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Hartley; TISSUE=Bone marrow;
RX PubMed=8243060; DOI=10.1016/0305-0491(93)90317-x;
RA Nagaoka I., Nonoguchi A., Yamashita T.;
RT "Guinea-pig neutrophil cationic peptides are encoded by at least three
RT kinds of mRNA transcripts.";
RL Comp. Biochem. Physiol. 106B:387-390(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Hartley; TISSUE=Liver;
RX PubMed=8173076; DOI=10.3109/10425179309020151;
RA Nagaoka I., Nonoguchi A., Yamashita T.;
RT "Cloning and characterization of the guinea pig neutrophil cationic
RT peptide-1 and -2 genes.";
RL DNA Seq. 4:123-128(1993).
RN [3]
RP PROTEIN SEQUENCE OF 63-93.
RC TISSUE=Peritoneal neutrophil;
RX PubMed=3623703; DOI=10.1128/iai.55.9.2281-2286.1987;
RA Selsted M.E., Harwig S.S.L.;
RT "Purification, primary structure, and antimicrobial activities of a guinea
RT pig neutrophil defensin.";
RL Infect. Immun. 55:2281-2286(1987).
RN [4]
RP PROTEIN SEQUENCE OF 63-93.
RC TISSUE=Bone marrow;
RX PubMed=1659400; DOI=10.1016/s0006-291x(05)81101-5;
RA Hu J., Bennett H.P.J., Lazure C., Solomon S.;
RT "Isolation and characterization of corticostatic peptides from guinea pig
RT bone marrow.";
RL Biochem. Biophys. Res. Commun. 180:558-565(1991).
RN [5]
RP PROTEIN SEQUENCE OF 63-93.
RC TISSUE=Neutrophil;
RX PubMed=2473036; DOI=10.1128/iai.57.8.2405-2409.1989;
RA Yamashita T., Saito K.;
RT "Purification, primary structure, and biological activity of guinea pig
RT neutrophil cationic peptides.";
RL Infect. Immun. 57:2405-2409(1989).
CC -!- FUNCTION: Has antibiotic, anti-fungi and antiviral activity.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Bone marrow.
CC -!- SIMILARITY: Belongs to the alpha-defensin family. {ECO:0000305}.
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DR EMBL; D14118; BAA03181.1; -; mRNA.
DR EMBL; D37972; BAA07190.1; -; Genomic_DNA.
DR EMBL; D14120; BAA03183.1; -; Genomic_DNA.
DR RefSeq; NP_001166528.1; NM_001173057.1.
DR AlphaFoldDB; Q64365; -.
DR SMR; Q64365; -.
DR GeneID; 100192401; -.
DR KEGG; cpoc:100192401; -.
DR CTD; 100192401; -.
DR OrthoDB; 1610714at2759; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR GO; GO:0050832; P:defense response to fungus; IEA:UniProtKB-KW.
DR GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
DR InterPro; IPR016327; Alpha-defensin.
DR InterPro; IPR006081; Alpha-defensin_C.
DR InterPro; IPR002366; Alpha-defensin_propep.
DR InterPro; IPR006080; Defensin_beta/alpha.
DR PANTHER; PTHR11876; PTHR11876; 1.
DR Pfam; PF00323; Defensin_1; 1.
DR Pfam; PF00879; Defensin_propep; 1.
DR PIRSF; PIRSF001875; Alpha-defensin; 1.
DR SMART; SM00048; DEFSN; 1.
DR PROSITE; PS00269; DEFENSIN; 1.
PE 1: Evidence at protein level;
KW Antibiotic; Antimicrobial; Antiviral defense; Defensin;
KW Direct protein sequencing; Disulfide bond; Fungicide; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT PROPEP 20..62
FT /evidence="ECO:0000269|PubMed:1659400,
FT ECO:0000269|PubMed:2473036, ECO:0000269|PubMed:3623703"
FT /id="PRO_0000006767"
FT PEPTIDE 63..93
FT /note="Neutrophil cationic peptide 1"
FT /id="PRO_0000006768"
FT DISULFID 65..93
FT /evidence="ECO:0000250"
FT DISULFID 67..82
FT /evidence="ECO:0000250"
FT DISULFID 72..92
FT /evidence="ECO:0000250"
SQ SEQUENCE 93 AA; 10478 MW; 6D5AAC5A1EBEB8AE CRC64;
MRTVPLFAAC LLLTLMAQAE PLPRAADHSD TKMKGDREDH VAVISFWEEE STSLQDAGAG
AGRRCICTTR TCRFPYRRLG TCIFQNRVYT FCC
