ID   DEF1_CANAW              Reviewed;         492 AA.
AC   C4YHS3;
DT   08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   25-MAY-2022, entry version 35.
DE   RecName: Full=RNA polymerase II degradation factor 1;
GN   Name=DEF1; ORFNames=CAWG_03622;
OS   Candida albicans (strain WO-1) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=294748;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WO-1;
RX   PubMed=19465905; DOI=10.1038/nature08064;
RA   Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA   Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA   Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA   Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA   Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA   Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA   Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA   Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA   Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA   Birren B.W., Kellis M., Cuomo C.A.;
RT   "Evolution of pathogenicity and sexual reproduction in eight Candida
RT   genomes.";
RL   Nature 459:657-662(2009).
CC   -!- FUNCTION: RNA polymerase II degradation factor recruits the
CC       ubiquitination machinery to the RNA polymerase II for
CC       polyubiquitination, removal and degradation, when RAD26 fails to
CC       efficiently displace stalled RNA polymerase II. Also involved in
CC       telomere length regulation (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome, telomere
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DEF1 family. {ECO:0000305}.
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DR   EMBL; CH672349; EEQ45305.1; -; Genomic_DNA.
DR   AlphaFoldDB; C4YHS3; -.
DR   SMR; C4YHS3; -.
DR   STRING; 5476.C4YHS3; -.
DR   EnsemblFungi; EEQ45305; EEQ45305; CAWG_03622.
DR   VEuPathDB; FungiDB:CAWG_03622; -.
DR   HOGENOM; CLU_043289_0_0_1; -.
DR   OMA; KENTHPP; -.
DR   Proteomes; UP000001429; Chromosome 4, Supercontig 1.4.
DR   GO; GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0043130; F:ubiquitin binding; IEA:InterPro.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   InterPro; IPR003892; CUE.
DR   Pfam; PF02845; CUE; 1.
DR   PROSITE; PS51140; CUE; 1.
PE   3: Inferred from homology;
KW   Chromosome; DNA damage; DNA repair; DNA-binding; Nucleus; Telomere;
KW   Ubl conjugation pathway.
FT   CHAIN           1..492
FT                   /note="RNA polymerase II degradation factor 1"
FT                   /id="PRO_0000405662"
FT   DOMAIN          23..66
FT                   /note="CUE"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00468"
FT   REGION          1..25
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          73..309
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        89..130
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        147..178
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        213..227
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        230..244
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   492 AA;  54131 MW;  B802C4A68D04A271 CRC64;
     MSTYRKTYKN QSKRFNNGNN SNSTSTELTN LVEMFPDWEA DELQGLLSEN DNSLEIVIDL
     IVNNKVSKWE PIKKEKHKKK EHKDDTTDSV TGNANGASNS GSSNSTTASG DRRLNNKAKA
     STSSRPPKRQ QHPNAAHKKN EKTERSKAST VSTTTTSATS SVTKESVPPS NSWAAALSND
     KPKKQETKSE ASESIPSSND GGDAETVPEV EQAETLEESH QEPENVEEPI ESVSEQSQPE
     NTKPVLKSAA IPEPKQGSWA SAIAPKTKPK PKTVSKPVPQ PEESKPEEHI PVQEEAQPVE
     SVLEDKPAVE AVQPVQPPVE DEPVEAPAAS SVAAVADASF SEPTASSIID QQPQVVLPTT
     QQQVDSVGIS FGSLSVDAGE PKEAAEVIQD ETISEQVQPE QQQQSQQQPL QEQQRYGLYN
     QQPTQQRYQQ NNYQQQGQYS KQQQQQLQQQ NTSQPTQQQT TIRLLWSIST TTISSTNSST
     RCSIWWLSWI LL