DEF1_CLAL4
ID DEF1_CLAL4 Reviewed; 671 AA.
AC C4Y1P0;
DT 08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT 28-JUL-2009, sequence version 1.
DT 25-MAY-2022, entry version 31.
DE RecName: Full=RNA polymerase II degradation factor 1;
GN Name=DEF1; ORFNames=CLUG_02122;
OS Clavispora lusitaniae (strain ATCC 42720) (Yeast) (Candida lusitaniae).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Metschnikowiaceae; Clavispora.
OX NCBI_TaxID=306902;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 42720;
RX PubMed=19465905; DOI=10.1038/nature08064;
RA Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA Birren B.W., Kellis M., Cuomo C.A.;
RT "Evolution of pathogenicity and sexual reproduction in eight Candida
RT genomes.";
RL Nature 459:657-662(2009).
CC -!- FUNCTION: RNA polymerase II degradation factor recruits the
CC ubiquitination machinery to the RNA polymerase II for
CC polyubiquitination, removal and degradation, when RAD26 fails to
CC efficiently displace stalled RNA polymerase II. Also involved in
CC telomere length regulation (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome, telomere
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the DEF1 family. {ECO:0000305}.
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DR EMBL; CH408077; EEQ37999.1; -; Genomic_DNA.
DR RefSeq; XP_002618663.1; XM_002618617.1.
DR AlphaFoldDB; C4Y1P0; -.
DR SMR; C4Y1P0; -.
DR STRING; 306902.C4Y1P0; -.
DR EnsemblFungi; EEQ37999; EEQ37999; CLUG_02122.
DR GeneID; 8499323; -.
DR KEGG; clu:CLUG_02122; -.
DR VEuPathDB; FungiDB:CLUG_02122; -.
DR HOGENOM; CLU_438800_0_0_1; -.
DR InParanoid; C4Y1P0; -.
DR OMA; EPANVHV; -.
DR Proteomes; UP000007703; Unassembled WGS sequence.
DR GO; GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0043130; F:ubiquitin binding; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR InterPro; IPR003892; CUE.
DR Pfam; PF02845; CUE; 1.
DR PROSITE; PS51140; CUE; 1.
PE 3: Inferred from homology;
KW Chromosome; DNA damage; DNA repair; DNA-binding; Nucleus;
KW Reference proteome; Telomere; Ubl conjugation pathway.
FT CHAIN 1..671
FT /note="RNA polymerase II degradation factor 1"
FT /id="PRO_0000405666"
FT DOMAIN 22..65
FT /note="CUE"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00468"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 66..266
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 294..439
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 480..516
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 546..577
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 601..651
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12..27
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 67..85
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 138..158
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 164..189
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 222..236
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 331..373
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 400..414
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 424..439
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 495..515
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 546..564
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 610..627
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 671 AA; 72398 MW; 28C271010BC248AF CRC64;
MSQRKNHRGQ QKKAAASPSK SAASSQLQTL SEMFPAWEAD ELAALLSEHH DDVEIVIDLI
VNNKVSKWEP IKKEPKPKKR EEVITDSNAT QTSHAHNDAK PKHSRERPKN EKRRERKPVQ
RKEPSAAVQA AQAASPAPAA AASTSSTSSA SVPSNSWAAA LSKDAKPKQK KEEPEVKEPA
QEQEQPKEEQ EPAVAAATAA AASAASAPQE TQAAPAAPAA PVAPTTTTTN DHAEKPATTW
ASAIKPKAKP IKKKAPEHVP EEEVSEVVVV ETEVSDVVLP QQVAEVGVSF GSLALETEDV
PESQPEAQPK PEAQPESQPE PEVQPEAEPE IQQEPVQQEQ VQPQQVQQQV QSQPEQPQQP
VPVQTQEQPQ QPQQPQQPQQ PQQPQAQQPQ QPQQPQQPQQ PQQQPQQQGQ QPPHFEKPAQ
GYDYYPQFQQ TQQYQQAAGS VPGQYAYPSF DYSAAYGQLG QAGLGSVASP GYYPAAVNGA
AKPAAPAPAS AEIGQSPLVQ PNNMGQQSMQ SGQAQVPGAA PFGYPNYYNY FYNTPFYGNG
GMAASTTSYG AQQQPQSQQA AGENAPASGE PETNGVPAQA QANNQYYAQY YGQPNQFGSR
GGYPYSGYPA SQPYPQSAGQ EQPEGAQPSA PQGAPVPGVP SYPQQMPQYG AYQQFPQYGS
YQDSNQYRGW Y
