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DEF1_LACTC
ID   DEF1_LACTC              Reviewed;         733 AA.
AC   C5DGU9;
DT   08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   25-MAY-2022, entry version 48.
DE   RecName: Full=RNA polymerase II degradation factor 1;
GN   Name=DEF1; OrderedLocusNames=KLTH0D08470g;
OS   Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284)
OS   (Yeast) (Kluyveromyces thermotolerans).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Lachancea.
OX   NCBI_TaxID=559295;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 56472 / CBS 6340 / NRRL Y-8284;
RX   PubMed=19525356; DOI=10.1101/gr.091546.109;
RG   The Genolevures Consortium;
RA   Souciet J.-L., Dujon B., Gaillardin C., Johnston M., Baret P.V.,
RA   Cliften P., Sherman D.J., Weissenbach J., Westhof E., Wincker P., Jubin C.,
RA   Poulain J., Barbe V., Segurens B., Artiguenave F., Anthouard V.,
RA   Vacherie B., Val M.-E., Fulton R.S., Minx P., Wilson R., Durrens P.,
RA   Jean G., Marck C., Martin T., Nikolski M., Rolland T., Seret M.-L.,
RA   Casaregola S., Despons L., Fairhead C., Fischer G., Lafontaine I., Leh V.,
RA   Lemaire M., de Montigny J., Neuveglise C., Thierry A., Blanc-Lenfle I.,
RA   Bleykasten C., Diffels J., Fritsch E., Frangeul L., Goeffon A.,
RA   Jauniaux N., Kachouri-Lafond R., Payen C., Potier S., Pribylova L.,
RA   Ozanne C., Richard G.-F., Sacerdot C., Straub M.-L., Talla E.;
RT   "Comparative genomics of protoploid Saccharomycetaceae.";
RL   Genome Res. 19:1696-1709(2009).
CC   -!- FUNCTION: RNA polymerase II degradation factor recruits the
CC       ubiquitination machinery to the RNA polymerase II for
CC       polyubiquitination, removal and degradation, when RAD26 fails to
CC       efficiently displace stalled RNA polymerase II. Also involved in
CC       telomere length regulation (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome, telomere
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DEF1 family. {ECO:0000305}.
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DR   EMBL; CU928168; CAR22641.1; -; Genomic_DNA.
DR   RefSeq; XP_002553079.1; XM_002553033.1.
DR   AlphaFoldDB; C5DGU9; -.
DR   SMR; C5DGU9; -.
DR   STRING; 559295.C5DGU9; -.
DR   EnsemblFungi; CAR22641; CAR22641; KLTH0D08470g.
DR   GeneID; 8295315; -.
DR   KEGG; lth:KLTH0D08470g; -.
DR   eggNOG; ENOG502S359; Eukaryota.
DR   HOGENOM; CLU_023119_0_0_1; -.
DR   InParanoid; C5DGU9; -.
DR   OMA; NPYYHQY; -.
DR   OrthoDB; 1463481at2759; -.
DR   Proteomes; UP000002036; Chromosome D.
DR   GO; GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0043130; F:ubiquitin binding; IEA:InterPro.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   CDD; cd14368; CUE_DEF1_like; 1.
DR   InterPro; IPR003892; CUE.
DR   InterPro; IPR041803; DEF1_CUE.
DR   PROSITE; PS51140; CUE; 1.
PE   3: Inferred from homology;
KW   Chromosome; DNA damage; DNA repair; DNA-binding; Nucleus;
KW   Reference proteome; Telomere; Ubl conjugation pathway.
FT   CHAIN           1..733
FT                   /note="RNA polymerase II degradation factor 1"
FT                   /id="PRO_0000405669"
FT   DOMAIN          24..66
FT                   /note="CUE"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00468"
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          61..343
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          366..497
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          518..590
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          633..682
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        66..84
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        85..113
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        114..130
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        139..154
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        183..202
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        235..294
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        314..343
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        418..497
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        527..561
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   733 AA;  80081 MW;  6CE8FDB5078897F2 CRC64;
     MSTQSRKSNS SKQPHSTHKK LDPELKFKLE TLTELFPDWT NDDLIDLVQE YEDLETIIDK
     ITSGAATKWD EVKKPSKKER QREQQQQQQQ QQQAQLAAQQ ATQPSSQSHH NNHTHISPSH
     DGDHSHSAQT SHNHHQSKSS KFSSRERDSS SRSHKKSSNN AAASGPNGSG NARRERASGA
     SRVPATSAAS AASANASAVQ PDHLKTAVSA AKTASSTSWA AMASDKKAAK QSAQAKKAEE
     QQQEQQSPQQ AQHESTAPSP QQEAEPQSQS QSKSQPQSDN KSAESVSSTS TPATEDLEKP
     KKMTWAAIVK PKTKPSVKKS EPLEELEDLK REAAQISTEE PEAAEKVIEQ VIEQVEQTPE
     EVVEQVEVTV VPEEVSQESE EASAQQEETA EPAAPVVPAE PEAASSEEKA APAQPEQGTY
     SPVAQQQQPQ QQQQPQQQQQ AQQQQQQPTA YSEDKQSQAQ QAQSQQAQSF YQAQPQQYGS
     QTPQQTPQTL QQQNAAAAAA AAQQQYYMYQ NQFPGYSYPG MFDSQSYPAG YGQQYAPQSQ
     NGSQPQTAST QQSQSGQYGV PPGYASTGRD LGAASPMAAQ VQLQQQQQQQ PYGGSFMPYY
     HFYQQSFPYG QPQYGMAGQY PYQVPKAYNY MNQYQPQQGG QTPSSQSQQG EEAQQSAQQG
     QATASQGQAQ GSGSQGQAQT NAQQQAQLQQ YYQFQQQQQQ QQAAAAAAAA QQGGVPYGYS
     GYDFSSQATR GFY
 
 
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