ID   DEF1_PAPHA              Reviewed;          33 AA.
AC   P84757;
DT   07-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT   07-FEB-2006, sequence version 1.
DT   25-MAY-2022, entry version 32.
DE   RecName: Full=Defensin-1;
DE   AltName: Full=PhD1;
DE   Contains:
DE     RecName: Full=Defensin-2;
DE     AltName: Full=PhD2;
OS   Papio hamadryas (Hamadryas baboon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Papio.
OX   NCBI_TaxID=9557;
RN   [1]
RP   PROTEIN SEQUENCE, FUNCTION, AND MASS SPECTROMETRY.
RC   TISSUE=Leukocyte;
RX   PubMed=16978151; DOI=10.1134/s0006297906080098;
RA   Tsvetkova E.V., Aleshina G.M., Shamova O.V., Leonova L.E., Lehrer R.I.,
RA   Kokryakov V.N.;
RT   "Alpha-defensins from blood leukocytes of the monkey Papio hamadryas.";
RL   Biochemistry (Mosc.) 71:879-883(2006).
CC   -!- FUNCTION: Has antibacterial activity against the Gram-negative
CC       bacterium E.coli and the Gram-positive bacteria L.monocytogenes and
CC       S.aureus. Has antifungal activity against C.albicans.
CC       {ECO:0000269|PubMed:16978151}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- MASS SPECTROMETRY: [Defensin-1]: Mass=3939; Mass_error=1; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:16978151};
CC   -!- MASS SPECTROMETRY: [Defensin-2]: Mass=3781; Mass_error=1; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:16978151};
CC   -!- SIMILARITY: Belongs to the alpha-defensin family. {ECO:0000255}.
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DR   AlphaFoldDB; P84757; -.
DR   SMR; P84757; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0050832; P:defense response to fungus; IEA:UniProtKB-KW.
DR   GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
DR   InterPro; IPR006081; Alpha-defensin_C.
DR   PROSITE; PS00269; DEFENSIN; 1.
PE   1: Evidence at protein level;
KW   Antibiotic; Antimicrobial; Defensin; Direct protein sequencing;
KW   Disulfide bond; Fungicide; Secreted.
FT   PEPTIDE         1..33
FT                   /note="Defensin-1"
FT                   /id="PRO_0000046065"
FT   PEPTIDE         2..33
FT                   /note="Defensin-2"
FT                   /id="PRO_0000046066"
FT   DISULFID        4..32
FT                   /evidence="ECO:0000250"
FT   DISULFID        6..21
FT                   /evidence="ECO:0000250|UniProtKB:P82319"
FT   DISULFID        11..31
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   33 AA;  3943 MW;  7E821E6020324BD0 CRC64;
     RRICRCRIGR CLGLEVYFGV CFLHGRLARR CCR