ID   DEF1_STOCA              Reviewed;          79 AA.
AC   O16136;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Defensin-1;
DE   Flags: Precursor;
GN   Name=SMD1;
OS   Stomoxys calcitrans (Stable fly) (Conops calcitrans).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC   Muscidae; Stomoxys.
OX   NCBI_TaxID=35570;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Midgut;
RX   PubMed=9326639; DOI=10.1073/pnas.94.21.11502;
RA   Lehane M.J., Wu D., Lehane S.M.;
RT   "Midgut-specific immune molecules are produced by the blood-sucking insect
RT   Stomoxys calcitrans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 94:11502-11507(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Midgut;
RX   PubMed=11903625; DOI=10.1046/j.0962-1075.2001.00296.x;
RA   Munks R.J.L., Hamilton J.V., Lehane S.M., Lehane M.J.;
RT   "Regulation of midgut defensin production in the blood-sucking insect
RT   Stomoxys calcitrans.";
RL   Insect Mol. Biol. 10:561-571(2001).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the invertebrate defensin family. Type 1
CC       subfamily. {ECO:0000255|PROSITE-ProRule:PRU00710}.
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DR   EMBL; AF013146; AAB66892.1; -; mRNA.
DR   EMBL; AF182163; AAD56535.1; -; Genomic_DNA.
DR   AlphaFoldDB; O16136; -.
DR   SMR; O16136; -.
DR   STRING; 35570.O16136; -.
DR   VEuPathDB; VectorBase:SCAU016912; -.
DR   Proteomes; UP000095300; Genome assembly.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; IEA:UniProt.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.30.10; -; 1.
DR   InterPro; IPR001542; Defensin_invertebrate/fungal.
DR   InterPro; IPR036574; Scorpion_toxin-like_sf.
DR   Pfam; PF01097; Defensin_2; 1.
DR   SUPFAM; SSF57095; SSF57095; 1.
DR   PROSITE; PS51378; INVERT_DEFENSINS; 1.
PE   3: Inferred from homology;
KW   Antibiotic; Antimicrobial; Defensin; Disulfide bond; Immunity;
KW   Innate immunity; Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   PROPEP          24..?
FT                   /id="PRO_0000006750"
FT   CHAIN           ?..79
FT                   /note="Defensin-1"
FT                   /id="PRO_0000006751"
FT   DISULFID        42..69
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00710"
FT   DISULFID        55..75
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00710"
FT   DISULFID        59..77
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00710"
SQ   SEQUENCE   79 AA;  8160 MW;  5F275B39EB641778 CRC64;
     MKFLNVVAIA LLVVACLAVY SNAAPHEGVK EVAAAKPMGI TCDLLSLWKV GHAACAAHCL
     VLGDVGGYCT KEGLCVCKE