DEF1_ZYGRC
ID DEF1_ZYGRC Reviewed; 757 AA.
AC C5E4K0;
DT 08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT 28-JUL-2009, sequence version 1.
DT 25-MAY-2022, entry version 52.
DE RecName: Full=RNA polymerase II degradation factor 1;
GN Name=DEF1; OrderedLocusNames=ZYRO0E06754g;
OS Zygosaccharomyces rouxii (strain ATCC 2623 / CBS 732 / NBRC 1130 / NCYC 568
OS / NRRL Y-229) (Candida mogii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Zygosaccharomyces.
OX NCBI_TaxID=559307;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 2623 / CBS 732 / BCRC 21506 / NBRC 1130 / NCYC 568 / NRRL
RC Y-229;
RX PubMed=19525356; DOI=10.1101/gr.091546.109;
RG The Genolevures Consortium;
RA Souciet J.-L., Dujon B., Gaillardin C., Johnston M., Baret P.V.,
RA Cliften P., Sherman D.J., Weissenbach J., Westhof E., Wincker P., Jubin C.,
RA Poulain J., Barbe V., Segurens B., Artiguenave F., Anthouard V.,
RA Vacherie B., Val M.-E., Fulton R.S., Minx P., Wilson R., Durrens P.,
RA Jean G., Marck C., Martin T., Nikolski M., Rolland T., Seret M.-L.,
RA Casaregola S., Despons L., Fairhead C., Fischer G., Lafontaine I., Leh V.,
RA Lemaire M., de Montigny J., Neuveglise C., Thierry A., Blanc-Lenfle I.,
RA Bleykasten C., Diffels J., Fritsch E., Frangeul L., Goeffon A.,
RA Jauniaux N., Kachouri-Lafond R., Payen C., Potier S., Pribylova L.,
RA Ozanne C., Richard G.-F., Sacerdot C., Straub M.-L., Talla E.;
RT "Comparative genomics of protoploid Saccharomycetaceae.";
RL Genome Res. 19:1696-1709(2009).
CC -!- FUNCTION: RNA polymerase II degradation factor recruits the
CC ubiquitination machinery to the RNA polymerase II for
CC polyubiquitination, removal and degradation, when RAD26 fails to
CC efficiently displace stalled RNA polymerase II. Also involved in
CC telomere length regulation (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome, telomere
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the DEF1 family. {ECO:0000305}.
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DR EMBL; CU928181; CAR30961.1; -; Genomic_DNA.
DR RefSeq; XP_002499216.1; XM_002499171.1.
DR AlphaFoldDB; C5E4K0; -.
DR SMR; C5E4K0; -.
DR STRING; 559307.C5E4K0; -.
DR EnsemblFungi; CAR30961; CAR30961; ZYRO0E06754g.
DR GeneID; 8204771; -.
DR KEGG; zro:ZYRO0E06754g; -.
DR HOGENOM; CLU_023119_0_0_1; -.
DR InParanoid; C5E4K0; -.
DR Proteomes; UP000008536; Chromosome E.
DR GO; GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0043130; F:ubiquitin binding; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR CDD; cd14368; CUE_DEF1_like; 1.
DR InterPro; IPR003892; CUE.
DR InterPro; IPR041803; DEF1_CUE.
DR PROSITE; PS51140; CUE; 1.
PE 3: Inferred from homology;
KW Chromosome; DNA damage; DNA repair; DNA-binding; Nucleus;
KW Reference proteome; Telomere; Ubl conjugation pathway.
FT CHAIN 1..757
FT /note="RNA polymerase II degradation factor 1"
FT /id="PRO_0000405673"
FT DOMAIN 21..63
FT /note="CUE"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00468"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 69..521
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 556..575
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 664..703
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..17
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 69..86
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 87..103
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 118..166
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 194..212
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 213..262
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 312..329
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 342..385
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 400..521
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 757 AA; 83228 MW; 4BBF5D50E71C9175 CRC64;
MSAQSRKSNS HNGKNSRVNP EIKFKLETLT ELFPDWTNDD LIDLVHEYDD LETIIDKITS
GAVTRWDEVK KPSKKERLEK RLEQQQQLQK EQQQHQLQQQ HYHAQDLDGH HGGSSSHHHT
KAGQGSGSRY SRDNNGTHSS SGGSNAKSKK QQQQQQQQQN GKPSLPSDNA RAAISRGKPA
SGGGSWAAVA SSDSKKHQQE EEEEEDQQQQ RPESSPEEPS ATTVQASETK TDGVEASASA
TSTAQSSTHA TATASTGNAA HNEKPKKMSW AAIAAPKPKV VQKKQSSLNN VGGLKKEINE
VAKETETPAA GQAQREPVSE TNDKATNNQG KKADAQHEDT ASKLSEQQQQ QQEQLQAQQQ
EQQQTQQQDQ SPIEFQSQGT NQEDTAQHNR PEEQKDTREI TSNQVQIDEQ EVAATSEPQE
PSQTAQAVAT EVNDGSKVKQ QQQQPTVGVE AGKPQQQQQQ EAYYQQQQQQ QQQQQQQYFA
QQQQYAQSQT PQHAPQQLSG QQAAVGQPNA NANASANANA AAAATAAQQQ YYMYQNQFPG
YTYPGMFDSP SYAYGQQQAY QQPSQPSAQA GFGTGTASQY SIPQGYAAAP AADMTTASTA
TASPVAGHAQ PQQQQPYGGS FLPYYAHFYQ QSFPYAQPQY GMAGQYPYQV PKAGYNYYQP
QRQTQGRNVQ QGQQSPGHSP SQQGEDVQQQ SQPTQQNQLQ NGQQPLNPQQ LQFQQYYQFQ
QQQQAAAAAA AAAAAQQGLP YGYTGYDYTS QASRGFY
