ID   DEF2_APIME              Reviewed;         104 AA.
AC   Q5MQL3;
DT   15-JUN-2010, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-2005, sequence version 1.
DT   25-MAY-2022, entry version 47.
DE   RecName: Full=Defensin-2;
DE   Flags: Precursor;
OS   Apis mellifera (Honeybee).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Apoidea; Apidae;
OC   Apis.
OX   NCBI_TaxID=7460;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RX   PubMed=15607651; DOI=10.1016/j.ibmb.2004.09.007;
RA   Klaudiny J., Albert S., Bachanova K., Kopernicky J., Simuth J.;
RT   "Two structurally different defensin genes, one of them encoding a novel
RT   defensin isoform, are expressed in honeybee Apis mellifera.";
RL   Insect Biochem. Mol. Biol. 35:11-22(2005).
CC   -!- FUNCTION: Antibacterial peptide mostly active against Gram-positive
CC       bacteria. {ECO:0000255|PROSITE-ProRule:PRU00710}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000255|PROSITE-ProRule:PRU00710}.
CC   -!- TISSUE SPECIFICITY: Low expression in head and thorax.
CC   -!- SIMILARITY: Belongs to the invertebrate defensin family. Type 1
CC       subfamily. {ECO:0000255|PROSITE-ProRule:PRU00710}.
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DR   EMBL; AY588474; AAT94401.1; -; mRNA.
DR   RefSeq; NP_001011638.1; NM_001011638.1.
DR   AlphaFoldDB; Q5MQL3; -.
DR   SMR; Q5MQL3; -.
DR   STRING; 7460.GB47618-PA; -.
DR   PaxDb; Q5MQL3; -.
DR   EnsemblMetazoa; NM_001011638; NP_001011638; GeneID_413397.
DR   GeneID; 413397; -.
DR   KEGG; ame:413397; -.
DR   CTD; 413397; -.
DR   eggNOG; ENOG502T7D8; Eukaryota.
DR   OrthoDB; 1600872at2759; -.
DR   PhylomeDB; Q5MQL3; -.
DR   Proteomes; UP000005203; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.30.10; -; 1.
DR   InterPro; IPR001542; Defensin_invertebrate/fungal.
DR   InterPro; IPR003614; Scorpion_toxin-like.
DR   InterPro; IPR036574; Scorpion_toxin-like_sf.
DR   Pfam; PF01097; Defensin_2; 1.
DR   SMART; SM00505; Knot1; 1.
DR   SUPFAM; SSF57095; SSF57095; 1.
DR   PROSITE; PS51378; INVERT_DEFENSINS; 1.
PE   2: Evidence at transcript level;
KW   Antibiotic; Antimicrobial; Defensin; Disulfide bond; Immunity;
KW   Innate immunity; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..104
FT                   /note="Defensin-2"
FT                   /id="PRO_0000394508"
FT   DISULFID        64..95
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00710"
FT   DISULFID        81..100
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00710"
FT   DISULFID        85..102
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00710"
SQ   SEQUENCE   104 AA;  11859 MW;  C87FA98B4C4ACC67 CRC64;
     MKFFVLFAIL IAIVHASCAS VPKVVYDGPI YELRQIEEEN IEPDTELMDS NEPLLPLRHR
     RVTCDVLSWQ SKWLSINHSA CAIRCLAQRR KGGSCRNGVC ICRK