DEF2_CAVPO
ID DEF2_CAVPO Reviewed; 93 AA.
AC P49112; Q9R0Z5;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1996, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Neutrophil cationic peptide 2;
DE Short=CP-2;
DE AltName: Full=GNCP-2;
DE Flags: Precursor;
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141;
RN [1]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Hartley; TISSUE=Bone marrow;
RX PubMed=2013325; DOI=10.1016/0014-5793(91)80314-s;
RA Nagaoka I., Someya A., Iwabuchi K., Yamashita T.;
RT "Characterization of cDNA clones encoding guinea pig neutrophil cationic
RT peptides.";
RL FEBS Lett. 280:287-291(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Hartley; TISSUE=Liver;
RX PubMed=1592112; DOI=10.1016/0014-5793(92)80471-r;
RA Nagaoka I., Someya A., Iwabuchi K., Yamashita T.;
RT "Structure of the guinea pig neutrophil cationic peptide gene.";
RL FEBS Lett. 303:31-35(1992).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Hartley; TISSUE=Liver;
RX PubMed=8173076; DOI=10.3109/10425179309020151;
RA Nagaoka I., Nonoguchi A., Yamashita T.;
RT "Cloning and characterization of the guinea pig neutrophil cationic
RT peptide-1 and -2 genes.";
RL DNA Seq. 4:123-128(1993).
CC -!- FUNCTION: Has antibiotic, anti-fungi and antiviral activity.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the alpha-defensin family. {ECO:0000305}.
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DR EMBL; X63676; CAA45215.1; -; mRNA.
DR EMBL; X63677; CAA45216.3; -; Genomic_DNA.
DR EMBL; D14121; BAA03184.1; -; Genomic_DNA.
DR EMBL; D14122; BAA03185.1; -; Genomic_DNA.
DR EMBL; D37974; BAA07192.1; -; Genomic_DNA.
DR EMBL; D37973; BAA07191.1; -; Genomic_DNA.
DR PIR; S21169; S21169.
DR RefSeq; XP_003479427.1; XM_003479379.2.
DR AlphaFoldDB; P49112; -.
DR SMR; P49112; -.
DR Ensembl; ENSCPOT00000014985; ENSCPOP00000013372; ENSCPOG00000014840.
DR Ensembl; ENSCPOT00000042546; ENSCPOP00000032587; ENSCPOG00000014840.
DR GeneID; 100712792; -.
DR KEGG; cpoc:100712792; -.
DR GeneTree; ENSGT01030000240119; -.
DR HOGENOM; CLU_160803_0_0_1; -.
DR InParanoid; P49112; -.
DR OMA; ISFAWDE; -.
DR OrthoDB; 1610714at2759; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000014840; Expressed in liver and 4 other tissues.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR GO; GO:0050832; P:defense response to fungus; IEA:UniProtKB-KW.
DR GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
DR InterPro; IPR016327; Alpha-defensin.
DR InterPro; IPR006081; Alpha-defensin_C.
DR InterPro; IPR002366; Alpha-defensin_propep.
DR InterPro; IPR006080; Defensin_beta/alpha.
DR PANTHER; PTHR11876; PTHR11876; 1.
DR Pfam; PF00323; Defensin_1; 1.
DR Pfam; PF00879; Defensin_propep; 1.
DR PIRSF; PIRSF001875; Alpha-defensin; 1.
DR SMART; SM00048; DEFSN; 1.
DR PROSITE; PS00269; DEFENSIN; 1.
PE 3: Inferred from homology;
KW Antibiotic; Antimicrobial; Antiviral defense; Defensin; Disulfide bond;
KW Fungicide; Reference proteome; Secreted; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT PROPEP 20..62
FT /id="PRO_0000006769"
FT PEPTIDE 63..93
FT /note="Neutrophil cationic peptide 2"
FT /id="PRO_0000006770"
FT DISULFID 65..93
FT /evidence="ECO:0000250"
FT DISULFID 67..82
FT /evidence="ECO:0000250"
FT DISULFID 72..92
FT /evidence="ECO:0000250"
SQ SEQUENCE 93 AA; 10478 MW; 6D5AA80B1EBEB8AE CRC64;
MRTVPLFAAC LLLTLMAQAE PLPRAADHSD TKMKGDREDH VAVISFWEEE STSLQDAGAG
AGRRCICTTR TCRFPYRRLG TCLFQNRVYT FCC
