ID   DEF2_MACMU              Reviewed;          30 AA.
AC   P82317;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=Neutrophil defensin 2;
DE   AltName: Full=RMAD-2;
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544;
RN   [1]
RP   PROTEIN SEQUENCE, AND MASS SPECTROMETRY.
RC   TISSUE=Leukocyte;
RX   PubMed=10531277; DOI=10.1128/iai.67.11.6139-6144.1999;
RA   Tang Y.Q., Yuan J., Miller C.J., Selsted M.E.;
RT   "Isolation, characterization, cDNA cloning, and antimicrobial properties of
RT   two distinct subfamilies of alpha-defensins from rhesus macaque
RT   leukocytes.";
RL   Infect. Immun. 67:6139-6144(1999).
CC   -!- FUNCTION: Has bacteriostatic activity against L.monocytogenes, E.coli
CC       and S.aureus, microbicidial activity against L.monocytogenes and
CC       S.aureus and antifungal activity against C.neoformans.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- MASS SPECTROMETRY: Mass=3465.9; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:10531277};
CC   -!- SIMILARITY: Belongs to the alpha-defensin family. {ECO:0000305}.
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DR   PIR; B59076; B59076.
DR   AlphaFoldDB; P82317; -.
DR   SMR; P82317; -.
DR   PRIDE; P82317; -.
DR   Proteomes; UP000006718; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0050832; P:defense response to fungus; IEA:UniProtKB-KW.
DR   GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
DR   InterPro; IPR016327; Alpha-defensin.
DR   InterPro; IPR006081; Alpha-defensin_C.
DR   InterPro; IPR006080; Defensin_beta/alpha.
DR   PANTHER; PTHR11876; PTHR11876; 1.
DR   Pfam; PF00323; Defensin_1; 1.
DR   SMART; SM00048; DEFSN; 1.
DR   PROSITE; PS00269; DEFENSIN; 1.
PE   1: Evidence at protein level;
KW   Antibiotic; Antimicrobial; Defensin; Direct protein sequencing;
KW   Disulfide bond; Fungicide; Reference proteome; Secreted.
FT   PEPTIDE         1..30
FT                   /note="Neutrophil defensin 2"
FT                   /id="PRO_0000043634"
FT   DISULFID        2..30
FT                   /evidence="ECO:0000250"
FT   DISULFID        4..19
FT                   /evidence="ECO:0000250"
FT   DISULFID        9..29
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   30 AA;  3471 MW;  D617D04085E7E09F CRC64;
     ACYCRIPACL AGERRYGTCF YMGRVWAFCC