ID   DEF2_PINSY              Reviewed;          83 AA.
AC   A4L7R8;
DT   23-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 25.
DE   RecName: Full=Defensin-2;
DE   Flags: Precursor;
GN   Name=Def2 {ECO:0000312|EMBL:ABO61349.1};
OS   Pinus sylvestris (Scotch pine).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Pinopsida; Pinidae; Conifers I; Pinales; Pinaceae; Pinus;
OC   Pinus subgen. Pinus.
OX   NCBI_TaxID=3349;
RN   [1] {ECO:0000312|EMBL:ABO61349.1}
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Root {ECO:0000312|EMBL:ABO61349.1};
RX   PubMed=19253756;
RA   Koval'ova V.A., Hut R.T.;
RT   "Molecular cloning and characterization of Scotch pine Defensin-2.";
RL   Cyt. Genet. 42:55-60(2008).
CC   -!- FUNCTION: Plant defense peptide. Has antifungal activity.
CC       {ECO:0000250|UniProtKB:A4L7R7}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q43413}.
CC   -!- SIMILARITY: Belongs to the DEFL family. {ECO:0000255}.
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DR   EMBL; EF455617; ABO61349.1; -; mRNA.
DR   PDB; 7LNS; NMR; -; A=34-83.
DR   PDBsum; 7LNS; -.
DR   AlphaFoldDB; A4L7R8; -.
DR   SMR; A4L7R8; -.
DR   GO; GO:0005576; C:extracellular region; ISS:UniProtKB.
DR   GO; GO:0050832; P:defense response to fungus; ISS:UniProtKB.
DR   GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
DR   CDD; cd00107; Knot1; 1.
DR   Gene3D; 3.30.30.10; -; 1.
DR   InterPro; IPR008176; Defensin_plant.
DR   InterPro; IPR003614; Scorpion_toxin-like.
DR   InterPro; IPR036574; Scorpion_toxin-like_sf.
DR   PRINTS; PR00288; PUROTHIONIN.
DR   SMART; SM00505; Knot1; 1.
DR   SUPFAM; SSF57095; SSF57095; 1.
DR   PROSITE; PS00940; GAMMA_THIONIN; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Antimicrobial; Defensin; Disulfide bond; Fungicide; Secreted;
KW   Signal.
FT   SIGNAL          1..33
FT                   /evidence="ECO:0000255"
FT   CHAIN           34..83
FT                   /note="Defensin-2"
FT                   /id="PRO_0000392922"
FT   DISULFID        36..82
FT                   /evidence="ECO:0000250|UniProtKB:P32026"
FT   DISULFID        47..67
FT                   /evidence="ECO:0000250|UniProtKB:P32026"
FT   DISULFID        53..76
FT                   /evidence="ECO:0000250|UniProtKB:P32026"
FT   DISULFID        57..78
FT                   /evidence="ECO:0000250|UniProtKB:P32026"
SQ   SEQUENCE   83 AA;  8963 MW;  CE44E1A01E3731B6 CRC64;
     MAGKGVGTPL SALFLLVLLV VTIGMMEVQV AEGRMCKTPS AKFKGYCVSS TNCKNVCRTE
     GFPTGSCDFH ITSRKCYCYK PCP