ID   DEF2_RABIT              Reviewed;          34 AA.
AC   P07468;
DT   01-APR-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1988, sequence version 1.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=Corticostatin-2;
DE   AltName: Full=Antiadrenocorticotropin peptide II;
DE   AltName: Full=Corticostatin II;
DE            Short=CS-II;
DE   AltName: Full=Microbicidal peptide NP-3B;
DE   AltName: Full=Neutrophil antibiotic peptide NP-3B;
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX   NCBI_TaxID=9986;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Peritoneal neutrophil;
RX   PubMed=3988726; DOI=10.1016/s0021-9258(18)89110-4;
RA   Selsted M.E., Brown D.M., Delange R.J., Harwig S.S.L., Lehrer R.I.;
RT   "Primary structures of six antimicrobial peptides of rabbit peritoneal
RT   neutrophils.";
RL   J. Biol. Chem. 260:4579-4584(1985).
RN   [2]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Lung;
RX   PubMed=1311240; DOI=10.1210/endo.130.3.1311240;
RA   Zhu Q., Solomon S.;
RT   "Isolation and mode of action of rabbit corticostatic
RT   (antiadrenocorticotropin) peptides.";
RL   Endocrinology 130:1413-1423(1992).
CC   -!- FUNCTION: Microbicidal activity and inhibits corticotropin (ACTH)
CC       stimulated corticosterone production.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the alpha-defensin family. {ECO:0000305}.
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DR   PIR; C49195; C49195.
DR   AlphaFoldDB; P07468; -.
DR   SMR; P07468; -.
DR   Proteomes; UP000001811; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   InterPro; IPR006081; Alpha-defensin_C.
DR   InterPro; IPR006080; Defensin_beta/alpha.
DR   Pfam; PF00323; Defensin_1; 1.
DR   SMART; SM00048; DEFSN; 1.
DR   PROSITE; PS00269; DEFENSIN; 1.
PE   1: Evidence at protein level;
KW   Antibiotic; Antimicrobial; Defensin; Direct protein sequencing;
KW   Disulfide bond; Reference proteome; Secreted.
FT   PEPTIDE         1..34
FT                   /note="Corticostatin-2"
FT                   /id="PRO_0000044718"
FT   DISULFID        3..32
FT                   /evidence="ECO:0000250"
FT   DISULFID        5..21
FT                   /evidence="ECO:0000250"
FT   DISULFID        11..31
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   34 AA;  4076 MW;  D6B99E6C9CB24504 CRC64;
     GRCVCRKQLL CSYRERRIGD CKIRGVRFPF CCPR