DEF3_RABIT
ID DEF3_RABIT Reviewed; 95 AA.
AC P01376;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1990, sequence version 2.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Corticostatin-3;
DE AltName: Full=Antiadrenocorticotropin peptide III;
DE AltName: Full=Corticostatin III;
DE Short=CS-III;
DE AltName: Full=Macrophage antibiotic peptide MCP-1;
DE Short=NP-1;
DE Flags: Precursor;
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RX PubMed=2745983;
RA Ganz T., Rayner J.R., Valore E.V., Tumolo A., Talmadge K., Fuller F.;
RT "The structure of the rabbit macrophage defensin genes and their organ-
RT specific expression.";
RL J. Immunol. 143:1358-1365(1989).
RN [2]
RP PROTEIN SEQUENCE OF 63-95.
RC TISSUE=Lung macrophage;
RX PubMed=6643497; DOI=10.1016/s0021-9258(17)43888-9;
RA Selsted M.E., Brown D.M., Delange R.J., Lehrer R.I.;
RT "Primary structures of MCP-1 and MCP-2, natural peptide antibiotics of
RT rabbit lung macrophages.";
RL J. Biol. Chem. 258:14485-14489(1983).
RN [3]
RP PROTEIN SEQUENCE OF 63-95.
RC TISSUE=Peritoneal neutrophil;
RX PubMed=3988726; DOI=10.1016/s0021-9258(18)89110-4;
RA Selsted M.E., Brown D.M., Delange R.J., Harwig S.S.L., Lehrer R.I.;
RT "Primary structures of six antimicrobial peptides of rabbit peritoneal
RT neutrophils.";
RL J. Biol. Chem. 260:4579-4584(1985).
RN [4]
RP PROTEIN SEQUENCE OF 63-95.
RC TISSUE=Lung;
RX PubMed=1311240; DOI=10.1210/endo.130.3.1311240;
RA Zhu Q., Solomon S.;
RT "Isolation and mode of action of rabbit corticostatic
RT (antiadrenocorticotropin) peptides.";
RL Endocrinology 130:1413-1423(1992).
CC -!- FUNCTION: This peptide has antibiotic, anti-fungi and antiviral
CC activity. It also inhibits corticotropin (ACTH) stimulated
CC corticosterone production.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the alpha-defensin family. {ECO:0000305}.
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DR EMBL; M28883; AAA31387.1; -; mRNA.
DR EMBL; M28072; AAA31388.1; -; Genomic_DNA.
DR PIR; A45811; WTRBM1.
DR RefSeq; NP_001164486.1; NM_001171015.1.
DR AlphaFoldDB; P01376; -.
DR STRING; 9986.ENSOCUP00000002802; -.
DR TCDB; 1.C.19.1.2; the defensin (defensin) family.
DR Ensembl; ENSOCUT00000003227; ENSOCUP00000002802; ENSOCUG00000021307.
DR GeneID; 100009115; -.
DR KEGG; ocu:100009115; -.
DR CTD; 178982; -.
DR eggNOG; ENOG502T2EX; Eukaryota.
DR GeneTree; ENSGT00940000153268; -.
DR HOGENOM; CLU_160803_0_0_1; -.
DR InParanoid; P01376; -.
DR OMA; CRPAERR; -.
DR OrthoDB; 1610714at2759; -.
DR TreeFam; TF338414; -.
DR Proteomes; UP000001811; Unplaced.
DR Bgee; ENSOCUG00000021307; Expressed in lung and 18 other tissues.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0061844; P:antimicrobial humoral immune response mediated by antimicrobial peptide; IDA:UniProtKB.
DR GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR GO; GO:0050832; P:defense response to fungus; IEA:UniProtKB-KW.
DR GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR GO; GO:0031640; P:killing of cells of another organism; IDA:UniProtKB.
DR InterPro; IPR016327; Alpha-defensin.
DR InterPro; IPR006081; Alpha-defensin_C.
DR InterPro; IPR002366; Alpha-defensin_propep.
DR InterPro; IPR006080; Defensin_beta/alpha.
DR PANTHER; PTHR11876; PTHR11876; 1.
DR Pfam; PF00323; Defensin_1; 1.
DR Pfam; PF00879; Defensin_propep; 1.
DR PIRSF; PIRSF001875; Alpha-defensin; 1.
DR SMART; SM00048; DEFSN; 1.
DR PROSITE; PS00269; DEFENSIN; 1.
PE 1: Evidence at protein level;
KW Antibiotic; Antimicrobial; Antiviral defense; Defensin;
KW Direct protein sequencing; Disulfide bond; Fungicide; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT PROPEP 20..62
FT /evidence="ECO:0000269|PubMed:1311240,
FT ECO:0000269|PubMed:3988726, ECO:0000269|PubMed:6643497"
FT /id="PRO_0000006809"
FT PEPTIDE 63..95
FT /note="Corticostatin-3"
FT /id="PRO_0000006810"
FT DISULFID 65..93
FT /evidence="ECO:0000250"
FT DISULFID 67..82
FT /evidence="ECO:0000250"
FT DISULFID 72..92
FT /evidence="ECO:0000250"
SQ SEQUENCE 95 AA; 10460 MW; 58593721BB6EF032 CRC64;
MRTLALLAAI LLVALQAQAE HVSVSIDEVV DQQPPQAEDQ DVAIYVKEHE SSALEALGVK
AGVVCACRRA LCLPRERRAG FCRIRGRIHP LCCRR
