ID   DEF4_MESAU              Reviewed;          33 AA.
AC   P81468;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-1998, sequence version 1.
DT   25-MAY-2022, entry version 54.
DE   RecName: Full=Neutrophil defensin 4;
DE   AltName: Full=HANP-4;
OS   Mesocricetus auratus (Golden hamster).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC   Cricetidae; Cricetinae; Mesocricetus.
OX   NCBI_TaxID=10036;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=8890190; DOI=10.1128/iai.64.11.4444-4449.1996;
RA   Mak P., Wojcik K., Thogersen I.B., Dubin A.;
RT   "Isolation, antimicrobial activities, and primary structures of hamster
RT   neutrophil defensins.";
RL   Infect. Immun. 64:4444-4449(1996).
CC   -!- FUNCTION: Bactericidal activity, greater against Gram-positive
CC       bacteria. Low anti-fungi activity.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- PTM: HANP-2 could be a product of proteolytic N-terminal amino acid
CC       removal from HANP-4.
CC   -!- SIMILARITY: Belongs to the alpha-defensin family. {ECO:0000305}.
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DR   AlphaFoldDB; P81468; -.
DR   SMR; P81468; -.
DR   Proteomes; UP000189706; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0050832; P:defense response to fungus; IEA:UniProtKB-KW.
DR   GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
DR   InterPro; IPR006081; Alpha-defensin_C.
DR   Pfam; PF00323; Defensin_1; 1.
DR   PROSITE; PS00269; DEFENSIN; 1.
PE   1: Evidence at protein level;
KW   Antibiotic; Antimicrobial; Defensin; Direct protein sequencing;
KW   Disulfide bond; Fungicide; Reference proteome; Secreted.
FT   PEPTIDE         1..33
FT                   /note="Neutrophil defensin 4"
FT                   /id="PRO_0000044717"
FT   DISULFID        3..31
FT                   /evidence="ECO:0000250"
FT   DISULFID        5..20
FT                   /evidence="ECO:0000250"
FT   DISULFID        10..30
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   33 AA;  3821 MW;  23097FE7D474AD65 CRC64;
     VTCFCKRPVC DSGETQIGYC RLGNTFYRLC CRQ