DEF4_MESAU
ID DEF4_MESAU Reviewed; 33 AA.
AC P81468;
DT 15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT 15-DEC-1998, sequence version 1.
DT 25-MAY-2022, entry version 54.
DE RecName: Full=Neutrophil defensin 4;
DE AltName: Full=HANP-4;
OS Mesocricetus auratus (Golden hamster).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Mesocricetus.
OX NCBI_TaxID=10036;
RN [1]
RP PROTEIN SEQUENCE.
RX PubMed=8890190; DOI=10.1128/iai.64.11.4444-4449.1996;
RA Mak P., Wojcik K., Thogersen I.B., Dubin A.;
RT "Isolation, antimicrobial activities, and primary structures of hamster
RT neutrophil defensins.";
RL Infect. Immun. 64:4444-4449(1996).
CC -!- FUNCTION: Bactericidal activity, greater against Gram-positive
CC bacteria. Low anti-fungi activity.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- PTM: HANP-2 could be a product of proteolytic N-terminal amino acid
CC removal from HANP-4.
CC -!- SIMILARITY: Belongs to the alpha-defensin family. {ECO:0000305}.
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DR AlphaFoldDB; P81468; -.
DR SMR; P81468; -.
DR Proteomes; UP000189706; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR GO; GO:0050832; P:defense response to fungus; IEA:UniProtKB-KW.
DR GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
DR InterPro; IPR006081; Alpha-defensin_C.
DR Pfam; PF00323; Defensin_1; 1.
DR PROSITE; PS00269; DEFENSIN; 1.
PE 1: Evidence at protein level;
KW Antibiotic; Antimicrobial; Defensin; Direct protein sequencing;
KW Disulfide bond; Fungicide; Reference proteome; Secreted.
FT PEPTIDE 1..33
FT /note="Neutrophil defensin 4"
FT /id="PRO_0000044717"
FT DISULFID 3..31
FT /evidence="ECO:0000250"
FT DISULFID 5..20
FT /evidence="ECO:0000250"
FT DISULFID 10..30
FT /evidence="ECO:0000250"
SQ SEQUENCE 33 AA; 3821 MW; 23097FE7D474AD65 CRC64;
VTCFCKRPVC DSGETQIGYC RLGNTFYRLC CRQ