ID   DEF5_RABIT              Reviewed;          95 AA.
AC   P07467;
DT   01-APR-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1992, sequence version 2.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Neutrophil antibiotic peptide NP-4;
DE   AltName: Full=Microbicidal peptide NP-4;
DE   Flags: Precursor;
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX   NCBI_TaxID=9986;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=1613398; DOI=10.1002/jlb.51.6.634;
RA   Michaelson D., Couto M., Rayner J.R., Ganz T.;
RT   "Cationic defensins arise from charge-neutralized propeptides: a mechanism
RT   for avoiding leukocyte autocytotoxicity?";
RL   J. Leukoc. Biol. 51:634-639(1992).
RN   [2]
RP   PROTEIN SEQUENCE OF 63-95.
RC   TISSUE=Peritoneal neutrophil;
RX   PubMed=3988726; DOI=10.1016/s0021-9258(18)89110-4;
RA   Selsted M.E., Brown D.M., Delange R.J., Harwig S.S.L., Lehrer R.I.;
RT   "Primary structures of six antimicrobial peptides of rabbit peritoneal
RT   neutrophils.";
RL   J. Biol. Chem. 260:4579-4584(1985).
CC   -!- FUNCTION: Microbicidal activity.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the alpha-defensin family. {ECO:0000305}.
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DR   EMBL; M64601; AAA31238.1; -; mRNA.
DR   PIR; I46705; I46705.
DR   RefSeq; NP_001075768.1; NM_001082299.1.
DR   RefSeq; XP_008272397.1; XM_008274175.2.
DR   AlphaFoldDB; P07467; -.
DR   SMR; P07467; -.
DR   STRING; 9986.ENSOCUP00000020922; -.
DR   GeneID; 100009135; -.
DR   KEGG; ocu:100009135; -.
DR   eggNOG; ENOG502T2EX; Eukaryota.
DR   HOGENOM; CLU_160803_3_0_1; -.
DR   InParanoid; P07467; -.
DR   OMA; ESHTGRC; -.
DR   OrthoDB; 1610714at2759; -.
DR   TreeFam; TF338414; -.
DR   Proteomes; UP000001811; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   InterPro; IPR016327; Alpha-defensin.
DR   InterPro; IPR006081; Alpha-defensin_C.
DR   InterPro; IPR002366; Alpha-defensin_propep.
DR   InterPro; IPR006080; Defensin_beta/alpha.
DR   PANTHER; PTHR11876; PTHR11876; 1.
DR   Pfam; PF00323; Defensin_1; 1.
DR   Pfam; PF00879; Defensin_propep; 1.
DR   PIRSF; PIRSF001875; Alpha-defensin; 1.
DR   SMART; SM00048; DEFSN; 1.
DR   PROSITE; PS00269; DEFENSIN; 1.
PE   1: Evidence at protein level;
KW   Antibiotic; Antimicrobial; Defensin; Direct protein sequencing;
KW   Disulfide bond; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   PROPEP          20..62
FT                   /evidence="ECO:0000269|PubMed:3988726"
FT                   /id="PRO_0000006813"
FT   PEPTIDE         63..95
FT                   /note="Neutrophil antibiotic peptide NP-4"
FT                   /id="PRO_0000006814"
FT   DISULFID        65..93
FT                   /evidence="ECO:0000250"
FT   DISULFID        67..82
FT                   /evidence="ECO:0000250"
FT   DISULFID        72..92
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   95 AA;  10181 MW;  61C86A5807064B80 CRC64;
     MRTLALLAAI LLVTLQAQAE LHSGMADDGV DQQQPRAQDL DVAVYIKQDE TSPLEVLGAK
     AGVSCTCRRF SCGFGERASG SCTVNGVRHT LCCRR