ID   DEF5_RAT                Reviewed;          93 AA.
AC   P82106;
DT   24-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=Defensin 5;
DE   AltName: Full=Enteric defensin;
DE   AltName: Full=RD-5;
DE   Flags: Precursor;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   STRAIN=Sprague-Dawley; TISSUE=Small intestine;
RX   PubMed=10456932; DOI=10.1128/iai.67.9.4787-4793.1999;
RA   Condon M.R., Viera A., D'Alessio M., Diamond G.;
RT   "Induction of a rat enteric defensin gene by hemorrhagic shock.";
RL   Infect. Immun. 67:4787-4793(1999).
CC   -!- FUNCTION: Probably contributes to the antimicrobial barrier function of
CC       the small intestine.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Small intestine. Not present in heart, liver,
CC       spleen, kidney, large intestine and colon.
CC       {ECO:0000269|PubMed:10456932}.
CC   -!- INDUCTION: By hemorrhagic shock.
CC   -!- SIMILARITY: Belongs to the alpha-defensin family. {ECO:0000305}.
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DR   EMBL; AF115768; AAD22963.1; -; mRNA.
DR   AlphaFoldDB; P82106; -.
DR   STRING; 10116.ENSRNOP00000018529; -.
DR   PRIDE; P82106; -.
DR   UCSC; RGD:1304852; rat.
DR   PhylomeDB; P82106; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0019731; P:antibacterial humoral response; IBA:GO_Central.
DR   GO; GO:0061844; P:antimicrobial humoral immune response mediated by antimicrobial peptide; IBA:GO_Central.
DR   GO; GO:0071222; P:cellular response to lipopolysaccharide; IBA:GO_Central.
DR   GO; GO:0050829; P:defense response to Gram-negative bacterium; IBA:GO_Central.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; IBA:GO_Central.
DR   GO; GO:0002227; P:innate immune response in mucosa; IBA:GO_Central.
DR   GO; GO:0051673; P:membrane disruption in another organism; IBA:GO_Central.
DR   InterPro; IPR016327; Alpha-defensin.
DR   InterPro; IPR006081; Alpha-defensin_C.
DR   InterPro; IPR002366; Alpha-defensin_propep.
DR   PANTHER; PTHR11876; PTHR11876; 1.
DR   Pfam; PF00879; Defensin_propep; 1.
DR   PIRSF; PIRSF001875; Alpha-defensin; 1.
DR   PROSITE; PS00269; DEFENSIN; 1.
PE   2: Evidence at transcript level;
KW   Antibiotic; Antimicrobial; Defensin; Disulfide bond; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   PROPEP          20..58
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000006869"
FT   PEPTIDE         59..93
FT                   /note="Defensin 5"
FT                   /id="PRO_0000006870"
FT   DISULFID        64..92
FT                   /evidence="ECO:0000250"
FT   DISULFID        66..81
FT                   /evidence="ECO:0000250"
FT   DISULFID        71..91
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   93 AA;  10242 MW;  7D9A71CEBFC42431 CRC64;
     MKKLVLLSAL VLLALQVEAE PTPKTDEGTK TDEQPGKEDQ VVSVSIEGQG DPAFQDAVLR
     DLKCFCRRKS CNWGEGIMGI CKKRYGSPIL CCR