DEF6_MACMU
ID DEF6_MACMU Reviewed; 94 AA.
AC P82320;
DT 21-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 25-MAY-2022, entry version 77.
DE RecName: Full=Neutrophil defensin 6;
DE AltName: Full=RMAD-6;
DE Contains:
DE RecName: Full=Neutrophil defensin 7;
DE AltName: Full=RMAD-7;
DE Flags: Precursor;
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 62-94, AND MASS
RP SPECTROMETRY.
RC TISSUE=Bone marrow, and Leukocyte;
RX PubMed=10531277; DOI=10.1128/iai.67.11.6139-6144.1999;
RA Tang Y.Q., Yuan J., Miller C.J., Selsted M.E.;
RT "Isolation, characterization, cDNA cloning, and antimicrobial properties of
RT two distinct subfamilies of alpha-defensins from rhesus macaque
RT leukocytes.";
RL Infect. Immun. 67:6139-6144(1999).
CC -!- FUNCTION: Defensins 6 and 7 have bacteriostatic activity against Gram-
CC positive bacteria S.aureus and L.monocytogenes and Gram-negative
CC bacterium E.coli and antifungal activity against C.neoformans. Defensin
CC 7 has microbicidial activity against Gram-positive bacteria S.aureus
CC and L.monocytogenes.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- MASS SPECTROMETRY: [Neutrophil defensin 6]: Mass=3898.0; Method=MALDI;
CC Evidence={ECO:0000269|PubMed:10531277};
CC -!- MASS SPECTROMETRY: [Neutrophil defensin 7]: Mass=3740.0; Method=MALDI;
CC Evidence={ECO:0000269|PubMed:10531277};
CC -!- SIMILARITY: Belongs to the alpha-defensin family. {ECO:0000305}.
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DR EMBL; AF188272; AAF06316.1; -; mRNA.
DR PIR; F59076; F59076.
DR PIR; G59076; G59076.
DR AlphaFoldDB; P82320; -.
DR SMR; P82320; -.
DR Proteomes; UP000006718; Unplaced.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0019731; P:antibacterial humoral response; IBA:GO_Central.
DR GO; GO:0061844; P:antimicrobial humoral immune response mediated by antimicrobial peptide; IBA:GO_Central.
DR GO; GO:0071222; P:cellular response to lipopolysaccharide; IBA:GO_Central.
DR GO; GO:0050832; P:defense response to fungus; IEA:UniProtKB-KW.
DR GO; GO:0050829; P:defense response to Gram-negative bacterium; IBA:GO_Central.
DR GO; GO:0050830; P:defense response to Gram-positive bacterium; IBA:GO_Central.
DR GO; GO:0002227; P:innate immune response in mucosa; IBA:GO_Central.
DR GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
DR GO; GO:0051673; P:membrane disruption in another organism; IBA:GO_Central.
DR InterPro; IPR016327; Alpha-defensin.
DR InterPro; IPR006081; Alpha-defensin_C.
DR InterPro; IPR002366; Alpha-defensin_propep.
DR PANTHER; PTHR11876; PTHR11876; 1.
DR Pfam; PF00323; Defensin_1; 1.
DR Pfam; PF00879; Defensin_propep; 1.
DR PIRSF; PIRSF001875; Alpha-defensin; 1.
DR PROSITE; PS00269; DEFENSIN; 1.
PE 1: Evidence at protein level;
KW Antibiotic; Antimicrobial; Defensin; Direct protein sequencing;
KW Disulfide bond; Fungicide; Reference proteome; Secreted; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT PROPEP 20..61
FT /evidence="ECO:0000269|PubMed:10531277"
FT /id="PRO_0000006802"
FT PEPTIDE 62..94
FT /note="Neutrophil defensin 6"
FT /id="PRO_0000006803"
FT PEPTIDE 63..94
FT /note="Neutrophil defensin 7"
FT /id="PRO_0000006804"
FT DISULFID 65..93
FT /evidence="ECO:0000250"
FT DISULFID 67..82
FT /evidence="ECO:0000250"
FT DISULFID 72..92
FT /evidence="ECO:0000250"
SQ SEQUENCE 94 AA; 10307 MW; E06932080A06CCD2 CRC64;
MRTIAILAAI LLFALLAQAK SLQETADEAA TQEQPGEDDQ DLAVSFEENG LSTLRASGSQ
ARRTCRCRFG RCFRRESYSG SCNINGRISS LCCR
