DEF6_RABIT
ID DEF6_RABIT Reviewed; 95 AA.
AC P07466;
DT 01-APR-1988, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1992, sequence version 2.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=Neutrophil antibiotic peptide NP-5;
DE AltName: Full=Microbicidal peptide NP-5;
DE Flags: Precursor;
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=1613398; DOI=10.1002/jlb.51.6.634;
RA Michaelson D., Couto M., Rayner J.R., Ganz T.;
RT "Cationic defensins arise from charge-neutralized propeptides: a mechanism
RT for avoiding leukocyte autocytotoxicity?";
RL J. Leukoc. Biol. 51:634-639(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=8439302; DOI=10.1006/bbrc.1993.1149;
RA Sadro L.C., Tremblay A., Solomon S., Palfree R.G.E.;
RT "Differential expression of corticostatins/defensins: higher levels of CS-4
RT (NP-2) transcripts compared with CS-6 (NP-5) in rabbit lung.";
RL Biochem. Biophys. Res. Commun. 190:1009-1016(1993).
RN [3]
RP PROTEIN SEQUENCE OF 63-94.
RC TISSUE=Peritoneal neutrophil;
RX PubMed=3988726; DOI=10.1016/s0021-9258(18)89110-4;
RA Selsted M.E., Brown D.M., Delange R.J., Harwig S.S.L., Lehrer R.I.;
RT "Primary structures of six antimicrobial peptides of rabbit peritoneal
RT neutrophils.";
RL J. Biol. Chem. 260:4579-4584(1985).
RN [4]
RP STRUCTURE BY NMR OF 63-95.
RX PubMed=2843652; DOI=10.1016/0022-2836(88)90643-2;
RA Pardi A., Hare D.R., Selsted M.E., Morrison R.D., Bassolino D.A.,
RA Bach A.C. II;
RT "Solution structures of the rabbit neutrophil defensin NP-5.";
RL J. Mol. Biol. 201:625-636(1988).
RN [5]
RP STRUCTURE BY NMR OF 63-95.
RX PubMed=2611235; DOI=10.1021/bi00450a017;
RA Levy R.M., Bassolino D.A., Kitchen D.B., Pardi A.;
RT "Solution structures of proteins from NMR data and modeling: alternative
RT folds for neutrophil peptide 5.";
RL Biochemistry 28:9361-9372(1989).
RN [6]
RP STRUCTURE BY NMR OF 63-95.
RX PubMed=2207287; DOI=10.1002/bip.360291412;
RA Kominos D., Bassolino D.A., Levy R.M., Pardi A.;
RT "Analysis of side-chain conformational distributions in neutrophil peptide-
RT 5 NMR structures.";
RL Biopolymers 29:1807-1822(1990).
CC -!- FUNCTION: Microbicidal activity.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the alpha-defensin family. {ECO:0000305}.
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DR EMBL; S55578; AAB25448.1; -; mRNA.
DR EMBL; M64602; AAA31239.1; -; mRNA.
DR EMBL; L10842; AAA31425.1; -; mRNA.
DR PIR; JC1462; JC1462.
DR RefSeq; NP_001075769.1; NM_001082300.1.
DR AlphaFoldDB; P07466; -.
DR BMRB; P07466; -.
DR SMR; P07466; -.
DR STRING; 9986.ENSOCUP00000016335; -.
DR Ensembl; ENSOCUT00000030547; ENSOCUP00000016335; ENSOCUG00000023668.
DR GeneID; 100009136; -.
DR KEGG; ocu:100009136; -.
DR eggNOG; ENOG502T2EX; Eukaryota.
DR GeneTree; ENSGT00940000153268; -.
DR InParanoid; P07466; -.
DR OrthoDB; 1610714at2759; -.
DR TreeFam; TF338414; -.
DR Proteomes; UP000001811; Unplaced.
DR Bgee; ENSOCUG00000023668; Expressed in blood and 13 other tissues.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR InterPro; IPR016327; Alpha-defensin.
DR InterPro; IPR006081; Alpha-defensin_C.
DR InterPro; IPR002366; Alpha-defensin_propep.
DR InterPro; IPR006080; Defensin_beta/alpha.
DR PANTHER; PTHR11876; PTHR11876; 1.
DR Pfam; PF00323; Defensin_1; 1.
DR Pfam; PF00879; Defensin_propep; 1.
DR PIRSF; PIRSF001875; Alpha-defensin; 1.
DR SMART; SM00048; DEFSN; 1.
DR PROSITE; PS00269; DEFENSIN; 1.
PE 1: Evidence at protein level;
KW Antibiotic; Antimicrobial; Defensin; Direct protein sequencing;
KW Disulfide bond; Reference proteome; Secreted; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT PROPEP 20..62
FT /evidence="ECO:0000269|PubMed:3988726"
FT /id="PRO_0000006815"
FT PEPTIDE 63..95
FT /note="Neutrophil antibiotic peptide NP-5"
FT /id="PRO_0000006816"
FT DISULFID 65..93
FT /evidence="ECO:0000250"
FT DISULFID 67..82
FT /evidence="ECO:0000250"
FT DISULFID 72..92
FT /evidence="ECO:0000250"
SQ SEQUENCE 95 AA; 10122 MW; 09E2E111E11D4A24 CRC64;
MRTLALLAAI LLVTLQAQAE LHSGMADDGV DQQQPRAQDL DVAVYIKQDE TSPLEVLGAK
AGVFCTCRGF LCGSGERASG SCTINGVRHT LCCRR
