ID   DEF7_PANTR              Reviewed;          94 AA.
AC   Q5G859;
DT   29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=Defensin-7;
DE   AltName: Full=Defensin, alpha 7;
DE   Flags: Precursor;
GN   Name=DEFA7;
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9598;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=15494476; DOI=10.1152/physiolgenomics.00150.2004;
RA   Patil A., Hughes A.L., Zhang G.;
RT   "Rapid evolution and diversification of mammalian alpha-defensins as
RT   revealed by comparative analysis of rodent and primate genes.";
RL   Physiol. Genomics 20:1-11(2004).
CC   -!- FUNCTION: Has antimicrobial activity. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- MISCELLANEOUS: The human orthologous protein seems not to exist, its
CC       coding region does not have a start codon.
CC   -!- SIMILARITY: Belongs to the alpha-defensin family. {ECO:0000305}.
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DR   EMBL; AY746441; AAW78344.1; -; mRNA.
DR   AlphaFoldDB; Q5G859; -.
DR   STRING; 9598.ENSPTRP00000053246; -.
DR   PaxDb; Q5G859; -.
DR   eggNOG; ENOG502T2EX; Eukaryota.
DR   InParanoid; Q5G859; -.
DR   Proteomes; UP000002277; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005796; C:Golgi lumen; IEA:UniProt.
DR   GO; GO:0019731; P:antibacterial humoral response; IBA:GO_Central.
DR   GO; GO:0061844; P:antimicrobial humoral immune response mediated by antimicrobial peptide; IBA:GO_Central.
DR   GO; GO:0071222; P:cellular response to lipopolysaccharide; IBA:GO_Central.
DR   GO; GO:0050832; P:defense response to fungus; IEA:UniProtKB-KW.
DR   GO; GO:0050829; P:defense response to Gram-negative bacterium; IBA:GO_Central.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; IBA:GO_Central.
DR   GO; GO:0002227; P:innate immune response in mucosa; IBA:GO_Central.
DR   GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
DR   GO; GO:0051673; P:membrane disruption in another organism; IBA:GO_Central.
DR   InterPro; IPR016327; Alpha-defensin.
DR   InterPro; IPR006081; Alpha-defensin_C.
DR   InterPro; IPR002366; Alpha-defensin_propep.
DR   PANTHER; PTHR11876; PTHR11876; 1.
DR   Pfam; PF00323; Defensin_1; 1.
DR   Pfam; PF00879; Defensin_propep; 1.
DR   PIRSF; PIRSF001875; Alpha-defensin; 1.
PE   3: Inferred from homology;
KW   Antibiotic; Antimicrobial; Defensin; Disulfide bond; Fungicide;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..94
FT                   /note="Defensin-7"
FT                   /id="PRO_0000006794"
FT   DISULFID        65..93
FT                   /evidence="ECO:0000250"
FT   DISULFID        72..92
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   94 AA;  10363 MW;  3509690A1C130897 CRC64;
     MRTLTLLSAF LLVALQAWAE PLQARADEMP AQKQPPADDQ DVVIYFSGDD SSSLQVPGST
     KGLICHCRVL YCLFGEHLGG TSFIHGERYP ICCY