ID   DEF7_RABIT              Reviewed;          34 AA.
AC   P80223; P80224;
DT   01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1993, sequence version 1.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=Corticostatin-6;
DE   AltName: Full=Corticostatin VI;
DE            Short=CS-VI;
DE   AltName: Full=Neutrophil antibiotic peptide NP-6;
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX   NCBI_TaxID=9986;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   STRAIN=Japanese white; TISSUE=Spleen;
RX   PubMed=8397087; DOI=10.1111/j.1432-1033.1993.tb18185.x;
RA   Fuse N., Hayashi Y., Fukata J., Tominaga T., Ebisui O., Satoh Y.,
RA   Isohara T., Uno I., Imura H.;
RT   "Purification and characterization of new anti-adrenocorticotropin rabbit
RT   neutrophil peptides (defensins).";
RL   Eur. J. Biochem. 216:653-659(1993).
CC   -!- FUNCTION: Microbicidal activity and inhibits corticotropin (ACTH)
CC       stimulated corticosterone production.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Lung, spleen, small intestine, pituitary gland,
CC       adrenal medulla and plasma.
CC   -!- SIMILARITY: Belongs to the alpha-defensin family. {ECO:0000305}.
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DR   PIR; S36843; S36843.
DR   AlphaFoldDB; P80223; -.
DR   SMR; P80223; -.
DR   Proteomes; UP000001811; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   InterPro; IPR006081; Alpha-defensin_C.
DR   InterPro; IPR006080; Defensin_beta/alpha.
DR   Pfam; PF00323; Defensin_1; 1.
DR   SMART; SM00048; DEFSN; 1.
DR   PROSITE; PS00269; DEFENSIN; 1.
PE   1: Evidence at protein level;
KW   Antibiotic; Antimicrobial; Defensin; Direct protein sequencing;
KW   Disulfide bond; Reference proteome; Secreted.
FT   PEPTIDE         1..34
FT                   /note="Corticostatin-6"
FT                   /id="PRO_0000044719"
FT   DISULFID        3..31
FT                   /evidence="ECO:0000250"
FT   DISULFID        5..20
FT                   /evidence="ECO:0000250"
FT   DISULFID        10..30
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   34 AA;  4052 MW;  E0090709FA1512B9 CRC64;
     GICACRRRFC LNFEQFSGYC RVNGARYVRC CSRR