ID   DEFA4_ORNAN             Reviewed;          99 AA.
AC   P0C8A4;
DT   14-OCT-2008, integrated into UniProtKB/Swiss-Prot.
DT   14-OCT-2008, sequence version 1.
DT   03-AUG-2022, entry version 20.
DE   RecName: Full=Defensin-A4 {ECO:0000305|PubMed:18463304, ECO:0000305|PubMed:18662710};
DE            Short=DefA4 {ECO:0000303|PubMed:18463304};
DE            Short=OaDefA4 {ECO:0000303|PubMed:18662710};
DE   Flags: Precursor;
OS   Ornithorhynchus anatinus (Duckbill platypus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX   NCBI_TaxID=9258;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=18463304; DOI=10.1101/gr.7149808;
RA   Whittington C.M., Papenfuss A.T., Bansal P., Torres A.M., Wong E.S.,
RA   Deakin J.E., Graves T., Alsop A., Schatzkamer K., Kremitzki C.,
RA   Ponting C.P., Temple-Smith P., Warren W.C., Kuchel P.W., Belov K.;
RT   "Defensins and the convergent evolution of platypus and reptile venom
RT   genes.";
RL   Genome Res. 18:986-994(2008).
RN   [2]
RP   TISSUE SPECIFICITY.
RX   PubMed=18662710; DOI=10.1016/j.toxicon.2008.07.002;
RA   Whittington C.M., Papenfuss A.T., Kuchel P.W., Belov K.;
RT   "Expression patterns of platypus defensin and related venom genes across a
RT   range of tissue types reveal the possibility of broader functions for
RT   OvDLPs than previously suspected.";
RL   Toxicon 52:559-565(2008).
CC   -!- FUNCTION: Has antimicrobial activity. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Lowly expressed in spleen, and expressed at lower
CC       levels in kidney and lung. {ECO:0000269|PubMed:18662710}.
CC   -!- SIMILARITY: Belongs to the alpha-defensin family. {ECO:0000305}.
CC   -!- WEB RESOURCE: Name=Platypus resources;
CC       URL="https://www.twinkl.ch/search?q=platypus";
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DR   AlphaFoldDB; P0C8A4; -.
DR   SMR; P0C8A4; -.
DR   Ensembl; ENSOANT00000070813; ENSOANP00000047685; ENSOANG00000039902.
DR   Proteomes; UP000002279; Chromosome X2.
DR   Bgee; ENSOANG00000039902; Expressed in endometrium.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
PE   2: Evidence at transcript level;
KW   Antibiotic; Antimicrobial; Cleavage on pair of basic residues; Defensin;
KW   Disulfide bond; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   PROPEP          22..68
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000352689"
FT   PEPTIDE         71..99
FT                   /note="Defensin-A4"
FT                   /id="PRO_0000352690"
FT   DISULFID        73..97
FT                   /evidence="ECO:0000250"
FT   DISULFID        75..89
FT                   /evidence="ECO:0000250"
FT   DISULFID        79..96
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   99 AA;  11216 MW;  3675EF8880A8E362 CRC64;
     MKTLCLLFAV LCLVTWTQAR GAEVEENLTA QDGEVDIAGD NGDVQLTLNT DDFESFTLKT
     LTLGHPRVKR HSCVCRRICA ARQVRKGRCS RRRRICCLY