DEFA8_MOUSE
ID DEFA8_MOUSE Reviewed; 81 AA.
AC P50706;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 2.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=Alpha-defensin 8;
DE AltName: Full=Defensin-related cryptdin-8;
DE Flags: Precursor; Fragment;
GN Name=Defa8; Synonyms=Defcr8;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=CD-1; TISSUE=Intestinal crypt;
RX PubMed=7927786; DOI=10.1128/iai.62.11.5040-5047.1994;
RA Ouellette A.J., Hsieh M.M., Nosek M.T., Cano-Gauci D.F., Huttner K.M.,
RA Buick R.N., Selsted M.E.;
RT "Mouse Paneth cell defensins: primary structures and antibacterial
RT activities of numerous cryptdin isoforms.";
RL Infect. Immun. 62:5040-5047(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 47-81.
RC STRAIN=129/SvJ, and C3H/HeJ; TISSUE=Small intestine;
RX PubMed=8188287; DOI=10.1006/geno.1994.1093;
RA Huttner K.M., Selsted M.E., Ouellette A.J.;
RT "Structure and diversity of the murine cryptdin gene family.";
RL Genomics 19:448-453(1994).
CC -!- FUNCTION: Probably contributes to the antimicrobial barrier function of
CC the small bowel mucosa.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Paneth cells of the small bowel.
CC -!- SIMILARITY: Belongs to the alpha-defensin family. {ECO:0000305}.
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DR EMBL; U03036; AAA57176.1; -; mRNA.
DR PIR; I48891; I48891.
DR AlphaFoldDB; P50706; -.
DR SMR; P50706; -.
DR PRIDE; P50706; -.
DR MGI; MGI:99580; Defa8.
DR InParanoid; P50706; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; P50706; protein.
DR GO; GO:0005615; C:extracellular space; ISO:MGI.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; ISO:MGI.
DR GO; GO:0030496; C:midbody; ISO:MGI.
DR GO; GO:0030141; C:secretory granule; ISO:MGI.
DR GO; GO:0042803; F:protein homodimerization activity; ISO:MGI.
DR GO; GO:0019731; P:antibacterial humoral response; IBA:GO_Central.
DR GO; GO:0061844; P:antimicrobial humoral immune response mediated by antimicrobial peptide; ISO:MGI.
DR GO; GO:0071222; P:cellular response to lipopolysaccharide; IBA:GO_Central.
DR GO; GO:0050829; P:defense response to Gram-negative bacterium; ISO:MGI.
DR GO; GO:0050830; P:defense response to Gram-positive bacterium; ISO:MGI.
DR GO; GO:0045087; P:innate immune response; ISO:MGI.
DR GO; GO:0002227; P:innate immune response in mucosa; IBA:GO_Central.
DR GO; GO:0051873; P:killing by host of symbiont cells; ISO:MGI.
DR GO; GO:0031640; P:killing of cells of another organism; ISO:MGI.
DR GO; GO:0051673; P:membrane disruption in another organism; ISO:MGI.
DR GO; GO:0032757; P:positive regulation of interleukin-8 production; ISO:MGI.
DR GO; GO:1905710; P:positive regulation of membrane permeability; ISO:MGI.
DR GO; GO:0051289; P:protein homotetramerization; ISO:MGI.
DR InterPro; IPR016327; Alpha-defensin.
DR InterPro; IPR006081; Alpha-defensin_C.
DR InterPro; IPR002366; Alpha-defensin_propep.
DR InterPro; IPR006080; Defensin_beta/alpha.
DR PANTHER; PTHR11876; PTHR11876; 1.
DR Pfam; PF00323; Defensin_1; 1.
DR Pfam; PF00879; Defensin_propep; 1.
DR PIRSF; PIRSF001875; Alpha-defensin; 1.
DR SMART; SM00048; DEFSN; 1.
DR PROSITE; PS00269; DEFENSIN; 1.
PE 2: Evidence at transcript level;
KW Antibiotic; Antimicrobial; Defensin; Disulfide bond; Reference proteome;
KW Secreted; Signal.
FT SIGNAL <1..7
FT /evidence="ECO:0000255"
FT PROPEP 8..46
FT /evidence="ECO:0000250"
FT /id="PRO_0000006831"
FT PEPTIDE 47..81
FT /note="Alpha-defensin 8"
FT /id="PRO_0000006832"
FT REGION 1..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 52..80
FT /evidence="ECO:0000250"
FT DISULFID 54..69
FT /evidence="ECO:0000250"
FT DISULFID 59..79
FT /evidence="ECO:0000250"
FT NON_TER 1
SQ SEQUENCE 81 AA; 9226 MW; 374CA904D7EDDCF8 CRC64;
LAFQVQADPI QNTDEETKTE EQPGEDDQAV SVSFGDPEGS SLQEESLRDL VCYCRKRGCK
RREHMNGTCR KGHLMYTLCC R
