ID   DEFA_ANTMA              Reviewed;         227 AA.
AC   P23706;
DT   01-NOV-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1991, sequence version 1.
DT   25-MAY-2022, entry version 106.
DE   RecName: Full=Floral homeotic protein DEFICIENS;
GN   Name=DEFA;
OS   Antirrhinum majus (Garden snapdragon).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Lamiales; Plantaginaceae; Antirrhineae; Antirrhinum.
OX   NCBI_TaxID=4151;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=1968830; DOI=10.1002/j.1460-2075.1990.tb08152.x;
RA   Sommer H., Beltran J.-P., Huijser P., Pape H., Loennig W.-E., Saedler H.,
RA   Schwarz-Sommer Z.;
RT   "Deficiens, a homeotic gene involved in the control of flower morphogenesis
RT   in Antirrhinum majus: the protein shows homology to transcription
RT   factors.";
RL   EMBO J. 9:605-613(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=cv. Sippe 50;
RX   PubMed=1346760; DOI=10.1002/j.1460-2075.1992.tb05048.x;
RA   Schwarz-Sommer Z., Hue I., Huijser P., Flor P.J., Hansen R., Tetens F.,
RA   Loennig W.-E., Saedler H., Sommer H.;
RT   "Characterization of the Antirrhinum floral homeotic MADS-box gene
RT   deficiens: evidence for DNA binding and autoregulation of its persistent
RT   expression throughout flower development.";
RL   EMBO J. 11:251-263(1992).
CC   -!- FUNCTION: Transcription factor involved in the genetic control of
CC       flower development. Acts in conjunction with GLOBOSA (glo).
CC   -!- INTERACTION:
CC       P23706; Q03378: GLO; NbExp=6; IntAct=EBI-633463, EBI-633469;
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- MISCELLANEOUS: Mutations in defA cause transformation of petals into
CC       sepals and stamina into carpels.
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DR   EMBL; X52023; CAA36268.1; -; mRNA.
DR   EMBL; X62810; CAA44629.1; -; Genomic_DNA.
DR   PIR; S12378; S12378.
DR   AlphaFoldDB; P23706; -.
DR   SMR; P23706; -.
DR   IntAct; P23706; 1.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   CDD; cd00265; MADS_MEF2_like; 1.
DR   Gene3D; 3.40.1810.10; -; 1.
DR   InterPro; IPR033896; MADS_MEF2-like.
DR   InterPro; IPR002487; TF_Kbox.
DR   InterPro; IPR002100; TF_MADSbox.
DR   InterPro; IPR036879; TF_MADSbox_sf.
DR   Pfam; PF01486; K-box; 1.
DR   Pfam; PF00319; SRF-TF; 1.
DR   PRINTS; PR00404; MADSDOMAIN.
DR   SMART; SM00432; MADS; 1.
DR   SUPFAM; SSF55455; SSF55455; 1.
DR   PROSITE; PS51297; K_BOX; 1.
DR   PROSITE; PS00350; MADS_BOX_1; 1.
DR   PROSITE; PS50066; MADS_BOX_2; 1.
PE   1: Evidence at protein level;
KW   Activator; Developmental protein; DNA-binding; Nucleus; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..227
FT                   /note="Floral homeotic protein DEFICIENS"
FT                   /id="PRO_0000199454"
FT   DOMAIN          3..57
FT                   /note="MADS-box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00251"
FT   DOMAIN          84..174
FT                   /note="K-box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00629"
SQ   SEQUENCE   227 AA;  26279 MW;  95E3FF60924FDE8D CRC64;
     MARGKIQIKR IENQTNRQVT YSKRRNGLFK KAHELSVLCD AKVSIIMISS TQKLHEYISP
     TTATKQLFDQ YQKAVGVDLW SSHYEKMQEH LKKLNEVNRN LRREIRQRMG ESLNDLGYEQ
     IVNLIEDMDN SLKLIRERKY KVISNQIDTS KKKVRNVEEI HRNLVLEFDA RREDPHFGLV
     DNEGDYNSVL GFPNGGPRII ALRLPTNHHP TLHSGGGSDL TTFALLE