ID   DEFA_ZOPAT              Reviewed;          43 AA.
AC   P80033;
DT   01-NOV-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1991, sequence version 1.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=Defensin, isoforms B and C;
OS   Zophobas atratus (Giant mealworm beetle) (Zophobas rugipes).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC   Tenebrionidae; Zophobas.
OX   NCBI_TaxID=7074;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Hemolymph;
RX   PubMed=1761552; DOI=10.1016/s0021-9258(18)54260-5;
RA   Bulet P., Cociancich S., Dimarcq J.-L., Lambert J., Reichhart J.-M.,
RA   Hoffmann D., Hetru C., Hoffmann J.A.;
RT   "Insect immunity. Isolation from a coleopteran insect of a novel inducible
RT   antibacterial peptide and of new members of the insect defensin family.";
RL   J. Biol. Chem. 266:24520-24525(1991).
CC   -!- FUNCTION: Involved in anti Gram-positive activity of immune hemolymph
CC       of Z.atratus.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the invertebrate defensin family. Type 1
CC       subfamily. {ECO:0000255|PROSITE-ProRule:PRU00710}.
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DR   PIR; B41711; B41711.
DR   PIR; C41711; C41711.
DR   AlphaFoldDB; P80033; -.
DR   SMR; P80033; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.30.10; -; 1.
DR   InterPro; IPR001542; Defensin_invertebrate/fungal.
DR   InterPro; IPR036574; Scorpion_toxin-like_sf.
DR   Pfam; PF01097; Defensin_2; 1.
DR   SUPFAM; SSF57095; SSF57095; 1.
DR   PROSITE; PS51378; INVERT_DEFENSINS; 1.
PE   1: Evidence at protein level;
KW   Antibiotic; Antimicrobial; Defensin; Direct protein sequencing;
KW   Disulfide bond; Immunity; Innate immunity; Secreted.
FT   CHAIN           1..43
FT                   /note="Defensin, isoforms B and C"
FT                   /id="PRO_0000074475"
FT   DISULFID        3..34
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00710"
FT   DISULFID        20..40
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00710"
FT   DISULFID        24..42
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00710"
FT   VARIANT         30
FT                   /note="R -> T (in isoform C)"
SQ   SEQUENCE   43 AA;  4453 MW;  D63E7B100987FD2F CRC64;
     FTCDVLGFEI AGTKLNSAAC GAHCLALGRR GGYCNSKSVC VCR