ID   DEFB1_MACMU             Reviewed;          68 AA.
AC   O18794;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=Beta-defensin 1;
DE            Short=BD-1;
DE   AltName: Full=Defensin, beta 1;
DE   AltName: Full=RhBD-1;
DE   Flags: Precursor;
GN   Name=DEFB1;
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Kwok J., Hurlock G., Wu X., Penland C., Wine J.J.;
RL   Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=11238224; DOI=10.1128/cdli.8.2.370-375.2001;
RA   Bals R., Lang C., Weiner D.J., Vogelmeier C., Welsch U., Wilson J.M.;
RT   "Rhesus monkey (Macaca mulatta) mucosal antimicrobial peptides are close
RT   homologues of human molecules.";
RL   Clin. Diagn. Lab. Immunol. 8:370-375(2001).
CC   -!- FUNCTION: Has bactericidal activity. May act as a ligand for C-C
CC       chemokine receptor CCR6. Positively regulates the sperm motility and
CC       bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and
CC       triggers Ca2+ mobilization in the sperm which is important for its
CC       motility. {ECO:0000250|UniProtKB:P60022}.
CC   -!- SUBUNIT: Monomer. Homodimer. {ECO:0000250|UniProtKB:P60022}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P60022}. Membrane
CC       {ECO:0000250|UniProtKB:P60022}. Note=Associates with tumor cell
CC       membrane-derived microvesicles. {ECO:0000250|UniProtKB:P60022}.
CC   -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR   EMBL; AF014016; AAB66344.1; -; mRNA.
DR   EMBL; AF288285; AAK26258.1; -; mRNA.
DR   RefSeq; NP_001028029.1; NM_001032857.1.
DR   AlphaFoldDB; O18794; -.
DR   SMR; O18794; -.
DR   STRING; 9544.ENSMMUP00000005058; -.
DR   Ensembl; ENSMMUT00000086565; ENSMMUP00000077550; ENSMMUG00000053229.
DR   GeneID; 574187; -.
DR   KEGG; mcc:574187; -.
DR   CTD; 1672; -.
DR   VEuPathDB; HostDB:ENSMMUG00000053229; -.
DR   eggNOG; ENOG502TDMV; Eukaryota.
DR   GeneTree; ENSGT00390000017014; -.
DR   HOGENOM; CLU_189296_1_0_1; -.
DR   InParanoid; O18794; -.
DR   OMA; SGKAKCC; -.
DR   OrthoDB; 1584343at2759; -.
DR   Proteomes; UP000006718; Chromosome 8.
DR   Bgee; ENSMMUG00000053229; Expressed in kidney and 17 other tissues.
DR   ExpressionAtlas; O18794; baseline.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0019898; C:extrinsic component of membrane; ISS:UniProtKB.
DR   GO; GO:1990742; C:microvesicle; ISS:UniProtKB.
DR   GO; GO:0097225; C:sperm midpiece; ISS:UniProtKB.
DR   GO; GO:0031731; F:CCR6 chemokine receptor binding; ISS:UniProtKB.
DR   GO; GO:0042802; F:identical protein binding; ISS:UniProtKB.
DR   GO; GO:0019731; P:antibacterial humoral response; IEA:Ensembl.
DR   GO; GO:0061844; P:antimicrobial humoral immune response mediated by antimicrobial peptide; IEA:Ensembl.
DR   GO; GO:0035584; P:calcium-mediated signaling using intracellular calcium source; ISS:UniProtKB.
DR   GO; GO:0019933; P:cAMP-mediated signaling; ISS:UniProtKB.
DR   GO; GO:0050829; P:defense response to Gram-negative bacterium; ISS:UniProtKB.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; ISS:UniProtKB.
DR   GO; GO:0002227; P:innate immune response in mucosa; IBA:GO_Central.
DR   GO; GO:0060474; P:positive regulation of flagellated sperm motility involved in capacitation; ISS:UniProtKB.
DR   InterPro; IPR001855; Defensin_beta-typ.
DR   Pfam; PF00711; Defensin_beta; 1.
PE   3: Inferred from homology;
KW   Antibiotic; Antimicrobial; Defensin; Disulfide bond; Membrane;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   PROPEP          22..32
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000006909"
FT   PEPTIDE         33..68
FT                   /note="Beta-defensin 1"
FT                   /id="PRO_0000006910"
FT   DISULFID        37..66
FT                   /evidence="ECO:0000250"
FT   DISULFID        44..59
FT                   /evidence="ECO:0000250"
FT   DISULFID        49..67
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   68 AA;  7572 MW;  997336DEC3B0435E CRC64;
     MRTSYLLLFT LCLLLSEMAS GDNFLTGLGH RSDHYNCVRS GGQCLYSACP IYTRIQGTCY
     HGKAKCCK