DEFB1_ORNAN
ID DEFB1_ORNAN Reviewed; 66 AA.
AC P0C8A5;
DT 14-OCT-2008, integrated into UniProtKB/Swiss-Prot.
DT 14-OCT-2008, sequence version 1.
DT 03-AUG-2022, entry version 36.
DE RecName: Full=Defensin-B1 {ECO:0000305|PubMed:18463304, ECO:0000305|PubMed:18662710};
DE Short=DefB1 {ECO:0000303|PubMed:18463304};
DE Short=OaDefB1 {ECO:0000303|PubMed:18662710};
DE Flags: Precursor;
OS Ornithorhynchus anatinus (Duckbill platypus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX NCBI_TaxID=9258;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=18463304; DOI=10.1101/gr.7149808;
RA Whittington C.M., Papenfuss A.T., Bansal P., Torres A.M., Wong E.S.,
RA Deakin J.E., Graves T., Alsop A., Schatzkamer K., Kremitzki C.,
RA Ponting C.P., Temple-Smith P., Warren W.C., Kuchel P.W., Belov K.;
RT "Defensins and the convergent evolution of platypus and reptile venom
RT genes.";
RL Genome Res. 18:986-994(2008).
RN [2]
RP TISSUE SPECIFICITY.
RX PubMed=18662710; DOI=10.1016/j.toxicon.2008.07.002;
RA Whittington C.M., Papenfuss A.T., Kuchel P.W., Belov K.;
RT "Expression patterns of platypus defensin and related venom genes across a
RT range of tissue types reveal the possibility of broader functions for
RT OvDLPs than previously suspected.";
RL Toxicon 52:559-565(2008).
CC -!- FUNCTION: Has bactericidal activity. May act as a ligand for C-C
CC chemokine receptor CCR6. Positively regulates the sperm motility and
CC bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and
CC triggers Ca2+ mobilization in the sperm which is important for its
CC motility. {ECO:0000250|UniProtKB:P60022}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P60022}.
CC -!- TISSUE SPECIFICITY: Expressed at low levels in kidney, lung, and
CC spleen. {ECO:0000269|PubMed:18662710}.
CC -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
CC -!- WEB RESOURCE: Name=Platypus resources;
CC URL="https://www.twinkl.ch/search?q=platypus";
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DR AlphaFoldDB; P0C8A5; -.
DR SMR; P0C8A5; -.
DR HOGENOM; CLU_2830570_0_0_1; -.
DR Proteomes; UP000002279; Chromosome X2.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0097225; C:sperm midpiece; ISS:UniProtKB.
DR GO; GO:0031731; F:CCR6 chemokine receptor binding; ISS:UniProtKB.
DR GO; GO:0035584; P:calcium-mediated signaling using intracellular calcium source; ISS:UniProtKB.
DR GO; GO:0019933; P:cAMP-mediated signaling; ISS:UniProtKB.
DR GO; GO:0050829; P:defense response to Gram-negative bacterium; ISS:UniProtKB.
DR GO; GO:0050830; P:defense response to Gram-positive bacterium; ISS:UniProtKB.
DR GO; GO:0045087; P:innate immune response; IEA:InterPro.
DR GO; GO:0060474; P:positive regulation of flagellated sperm motility involved in capacitation; ISS:UniProtKB.
DR InterPro; IPR025933; Beta_defensin.
DR Pfam; PF13841; Defensin_beta_2; 1.
PE 2: Evidence at transcript level;
KW Antibiotic; Antimicrobial; Cleavage on pair of basic residues; Defensin;
KW Disulfide bond; Reference proteome; Secreted; Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT PEPTIDE 24..58
FT /note="Defensin-B1"
FT /id="PRO_0000352719"
FT PROPEP 61..66
FT /evidence="ECO:0000255"
FT /id="PRO_0000352720"
FT DISULFID 29..56
FT /evidence="ECO:0000250"
FT DISULFID 36..50
FT /evidence="ECO:0000250"
FT DISULFID 40..57
FT /evidence="ECO:0000250"
SQ SEQUENCE 66 AA; 7386 MW; 12E5184888B97469 CRC64;
MNAHVLLLCT ILFLLVHTPP VLGGMKEKCV TMGGYCRKQC RVQDALSGYC RNENPCCVRR
VLMEDG
