DEFB1_PANTR
ID DEFB1_PANTR Reviewed; 68 AA.
AC P60023; A4H1Z2; Q09753; Q95M69;
DT 21-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 29-MAY-2007, sequence version 2.
DT 03-AUG-2022, entry version 91.
DE RecName: Full=Beta-defensin 1;
DE Short=BD-1;
DE AltName: Full=Defensin, beta 1;
DE AltName: Full=cBD1;
DE Flags: Precursor;
GN Name=DEFB1;
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=11168821; DOI=10.1034/j.1600-0684.2000.290502.x;
RA Duits L.A., Langermans J.A.M., Paltansing S., van der Straaten T.,
RA Vervenne R.A.W., Frost P.A., Hiemstra P.S., Thomas A.W., Nibbering P.H.;
RT "Expression of beta-defensin-1 in chimpanzee (Pan troglodytes) airways.";
RL J. Med. Primatol. 29:318-323(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11862391; DOI=10.1007/s00251-001-0412-x;
RA Del Pero M., Boniotto M., Zuccon D., Cervella P., Spano A., Amoroso A.,
RA Crovella S.;
RT "Beta-defensin 1 gene variability among non-human primates.";
RL Immunogenetics 53:907-913(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Hollox E.J., Armour J.A.L.;
RT "Evolution and sequence variation of human beta-defensin genes.";
RL Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Has bactericidal activity. May act as a ligand for C-C
CC chemokine receptor CCR6. Positively regulates the sperm motility and
CC bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and
CC triggers Ca2+ mobilization in the sperm which is important for its
CC motility. {ECO:0000250|UniProtKB:P60022}.
CC -!- SUBUNIT: Monomer. Homodimer. {ECO:0000250|UniProtKB:P60022}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P60022}. Membrane
CC {ECO:0000250|UniProtKB:P60022}. Note=Associates with tumor cell
CC membrane-derived microvesicles. {ECO:0000250|UniProtKB:P60022}.
CC -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR EMBL; AF188607; AAF04110.1; -; mRNA.
DR EMBL; AY033749; AAK61462.1; -; Genomic_DNA.
DR EMBL; AY033735; AAK61462.1; JOINED; Genomic_DNA.
DR EMBL; AM410097; CAL68980.1; -; Genomic_DNA.
DR RefSeq; NP_001009151.1; NM_001009151.1.
DR AlphaFoldDB; P60023; -.
DR SMR; P60023; -.
DR STRING; 9598.ENSPTRP00000034184; -.
DR PaxDb; P60023; -.
DR Ensembl; ENSPTRT00000036989; ENSPTRP00000034184; ENSPTRG00000019951.
DR GeneID; 450100; -.
DR KEGG; ptr:450100; -.
DR CTD; 1672; -.
DR VGNC; VGNC:11964; DEFB1.
DR eggNOG; ENOG502TDMV; Eukaryota.
DR GeneTree; ENSGT00390000017014; -.
DR HOGENOM; CLU_189296_1_0_1; -.
DR InParanoid; P60023; -.
DR OMA; SGKAKCC; -.
DR OrthoDB; 1584343at2759; -.
DR Proteomes; UP000002277; Chromosome 8.
DR Bgee; ENSPTRG00000019951; Expressed in cortex of kidney and 17 other tissues.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0019898; C:extrinsic component of membrane; ISS:UniProtKB.
DR GO; GO:1990742; C:microvesicle; ISS:UniProtKB.
DR GO; GO:0097225; C:sperm midpiece; ISS:UniProtKB.
DR GO; GO:0031731; F:CCR6 chemokine receptor binding; ISS:UniProtKB.
DR GO; GO:0042802; F:identical protein binding; ISS:UniProtKB.
DR GO; GO:0019731; P:antibacterial humoral response; IEA:Ensembl.
DR GO; GO:0061844; P:antimicrobial humoral immune response mediated by antimicrobial peptide; IEA:Ensembl.
DR GO; GO:0035584; P:calcium-mediated signaling using intracellular calcium source; ISS:UniProtKB.
DR GO; GO:0019933; P:cAMP-mediated signaling; ISS:UniProtKB.
DR GO; GO:0050829; P:defense response to Gram-negative bacterium; ISS:UniProtKB.
DR GO; GO:0050830; P:defense response to Gram-positive bacterium; ISS:UniProtKB.
DR GO; GO:0045087; P:innate immune response; ISS:UniProtKB.
DR GO; GO:0002227; P:innate immune response in mucosa; IBA:GO_Central.
DR GO; GO:0060474; P:positive regulation of flagellated sperm motility involved in capacitation; ISS:UniProtKB.
DR GO; GO:0009617; P:response to bacterium; ISS:UniProtKB.
DR InterPro; IPR001855; Defensin_beta-typ.
DR Pfam; PF00711; Defensin_beta; 1.
PE 3: Inferred from homology;
KW Antibiotic; Antimicrobial; Defensin; Disulfide bond; Membrane;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT PROPEP 22..32
FT /evidence="ECO:0000250"
FT /id="PRO_0000006911"
FT PEPTIDE 33..68
FT /note="Beta-defensin 1"
FT /id="PRO_0000006912"
FT DISULFID 37..66
FT /evidence="ECO:0000250"
FT DISULFID 44..59
FT /evidence="ECO:0000250"
FT DISULFID 49..67
FT /evidence="ECO:0000250"
FT CONFLICT 61
FT /note="G -> R (in Ref. 1; AAF04110)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 68 AA; 7321 MW; F1AB76DEC3B14F88 CRC64;
MRTSYLLLFT LCLLLSEMAS GGNFLTGLGH RSDHYNCVSS GGQCLYSACP IFTKIQGTCY
GGKAKCCK
