DEFB1_PAPAN
ID DEFB1_PAPAN Reviewed; 68 AA.
AC P61262;
DT 10-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT 10-MAY-2004, sequence version 1.
DT 03-AUG-2022, entry version 66.
DE RecName: Full=Beta-defensin 1;
DE Short=BD-1;
DE AltName: Full=Defensin, beta 1;
DE Flags: Precursor;
GN Name=DEFB1;
OS Papio anubis (Olive baboon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Papio.
OX NCBI_TaxID=9555;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11862391; DOI=10.1007/s00251-001-0412-x;
RA Del Pero M., Boniotto M., Zuccon D., Cervella P., Spano A., Amoroso A.,
RA Crovella S.;
RT "Beta-defensin 1 gene variability among non-human primates.";
RL Immunogenetics 53:907-913(2002).
CC -!- FUNCTION: Has bactericidal activity. May act as a ligand for C-C
CC chemokine receptor CCR6. Positively regulates the sperm motility and
CC bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and
CC triggers Ca2+ mobilization in the sperm which is important for its
CC motility. {ECO:0000250|UniProtKB:P60022}.
CC -!- SUBUNIT: Monomer. Homodimer. {ECO:0000250|UniProtKB:P60022}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P60022}. Membrane
CC {ECO:0000250|UniProtKB:P60022}. Note=Associates with tumor cell
CC membrane-derived microvesicles. {ECO:0000250|UniProtKB:P60022}.
CC -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR EMBL; AY033761; AAK61474.1; -; Genomic_DNA.
DR EMBL; AY033747; AAK61474.1; JOINED; Genomic_DNA.
DR RefSeq; XP_003902440.1; XM_003902391.2.
DR AlphaFoldDB; P61262; -.
DR SMR; P61262; -.
DR STRING; 9555.ENSPANP00000004965; -.
DR Ensembl; ENSPANT00000021919; ENSPANP00000004965; ENSPANG00000000904.
DR GeneID; 100999102; -.
DR KEGG; panu:100999102; -.
DR CTD; 1672; -.
DR eggNOG; ENOG502TDMV; Eukaryota.
DR GeneTree; ENSGT00390000017014; -.
DR HOGENOM; CLU_189296_1_0_1; -.
DR OMA; SGKAKCC; -.
DR OrthoDB; 1584343at2759; -.
DR Proteomes; UP000028761; Chromosome 8.
DR Bgee; ENSPANG00000000904; Expressed in renal medulla and 49 other tissues.
DR GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR GO; GO:0019898; C:extrinsic component of membrane; ISS:UniProtKB.
DR GO; GO:1990742; C:microvesicle; ISS:UniProtKB.
DR GO; GO:0097225; C:sperm midpiece; ISS:UniProtKB.
DR GO; GO:0031731; F:CCR6 chemokine receptor binding; ISS:UniProtKB.
DR GO; GO:0042802; F:identical protein binding; ISS:UniProtKB.
DR GO; GO:0019731; P:antibacterial humoral response; IEA:Ensembl.
DR GO; GO:0061844; P:antimicrobial humoral immune response mediated by antimicrobial peptide; IEA:Ensembl.
DR GO; GO:0035584; P:calcium-mediated signaling using intracellular calcium source; ISS:UniProtKB.
DR GO; GO:0019933; P:cAMP-mediated signaling; ISS:UniProtKB.
DR GO; GO:0050829; P:defense response to Gram-negative bacterium; ISS:UniProtKB.
DR GO; GO:0050830; P:defense response to Gram-positive bacterium; ISS:UniProtKB.
DR GO; GO:0002227; P:innate immune response in mucosa; IEA:Ensembl.
DR GO; GO:0060474; P:positive regulation of flagellated sperm motility involved in capacitation; ISS:UniProtKB.
DR InterPro; IPR001855; Defensin_beta-typ.
DR Pfam; PF00711; Defensin_beta; 1.
PE 3: Inferred from homology;
KW Antibiotic; Antimicrobial; Defensin; Disulfide bond; Membrane;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT PROPEP 22..32
FT /evidence="ECO:0000250"
FT /id="PRO_0000006913"
FT PEPTIDE 33..68
FT /note="Beta-defensin 1"
FT /id="PRO_0000006914"
FT DISULFID 37..66
FT /evidence="ECO:0000250"
FT DISULFID 44..59
FT /evidence="ECO:0000250"
FT DISULFID 49..67
FT /evidence="ECO:0000250"
SQ SEQUENCE 68 AA; 7572 MW; 997336DEC3B0435E CRC64;
MRTSYLLLFT LCLLLSEMAS GDNFLTGLGH RSDHYNCVRS GGQCLYSACP IYTRIQGTCY
HGKAKCCK
