ID   DEFB1_PIG               Reviewed;          64 AA.
AC   O62697;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=Beta-defensin 1;
DE            Short=BD-1;
DE   AltName: Full=Defensin, beta 1;
DE   Flags: Precursor;
GN   Name=DEFB1;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=9537511; DOI=10.1016/s0014-5793(98)00134-3;
RA   Zhang G., Wu H., Shi J., Ganz T., Ross C., Blecha F.;
RT   "Molecular cloning and tissue expression of porcine beta-defensin-1.";
RL   FEBS Lett. 424:37-40(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=10446172; DOI=10.1074/jbc.274.34.24031;
RA   Zhang G., Hiraiwa H., Yasue H., Wu H., Ross C.R., Troyer D., Blecha F.;
RT   "Cloning and characterization of the gene for a new epithelial beta-
RT   defensin. Genomic structure, chromosomal localization, and evidence for its
RT   constitutive expression.";
RL   J. Biol. Chem. 274:24031-24037(1999).
CC   -!- FUNCTION: Has bactericidal activity. May act as a ligand for C-C
CC       chemokine receptor CCR6. Positively regulates the sperm motility and
CC       bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and
CC       triggers Ca2+ mobilization in the sperm which is important for its
CC       motility. {ECO:0000250|UniProtKB:P60022}.
CC   -!- SUBUNIT: Monomer. Homodimer. {ECO:0000250|UniProtKB:P60022}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P60022}. Membrane
CC       {ECO:0000250|UniProtKB:P60022}. Note=Associates with tumor cell
CC       membrane-derived microvesicles. {ECO:0000250|UniProtKB:P60022}.
CC   -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR   EMBL; AF031666; AAC39175.1; -; mRNA.
DR   EMBL; AF132038; AAD51137.1; -; Genomic_DNA.
DR   RefSeq; NP_999003.1; NM_213838.1.
DR   AlphaFoldDB; O62697; -.
DR   SMR; O62697; -.
DR   STRING; 9823.ENSSSCP00000022776; -.
DR   PaxDb; O62697; -.
DR   PRIDE; O62697; -.
DR   Ensembl; ENSSSCT00000024650; ENSSSCP00000025388; ENSSSCG00000027555.
DR   Ensembl; ENSSSCT00005005133; ENSSSCP00005002935; ENSSSCG00005003519.
DR   Ensembl; ENSSSCT00015042039; ENSSSCP00015016609; ENSSSCG00015031725.
DR   Ensembl; ENSSSCT00025002948; ENSSSCP00025001072; ENSSSCG00025002275.
DR   Ensembl; ENSSSCT00030057697; ENSSSCP00030026237; ENSSSCG00030041522.
DR   Ensembl; ENSSSCT00035038414; ENSSSCP00035015332; ENSSSCG00035029032.
DR   Ensembl; ENSSSCT00040087755; ENSSSCP00040038560; ENSSSCG00040064278.
DR   Ensembl; ENSSSCT00045008563; ENSSSCP00045005800; ENSSSCG00045005153.
DR   Ensembl; ENSSSCT00050102899; ENSSSCP00050044903; ENSSSCG00050075098.
DR   Ensembl; ENSSSCT00055001408; ENSSSCP00055001048; ENSSSCG00055000810.
DR   Ensembl; ENSSSCT00060015496; ENSSSCP00060006050; ENSSSCG00060011864.
DR   Ensembl; ENSSSCT00065007949; ENSSSCP00065003347; ENSSSCG00065005920.
DR   Ensembl; ENSSSCT00070054902; ENSSSCP00070046567; ENSSSCG00070027368.
DR   GeneID; 396819; -.
DR   KEGG; ssc:396819; -.
DR   CTD; 1672; -.
DR   eggNOG; ENOG502SYUI; Eukaryota.
DR   GeneTree; ENSGT00990000208661; -.
DR   HOGENOM; CLU_189296_4_1_1; -.
DR   InParanoid; O62697; -.
DR   OMA; SCHRNKG; -.
DR   OrthoDB; 1584343at2759; -.
DR   Reactome; R-SSC-1461957; Beta defensins.
DR   Proteomes; UP000008227; Chromosome 15.
DR   Proteomes; UP000314985; Chromosome 15.
DR   Bgee; ENSSSCG00000027555; Expressed in tonsil and 22 other tissues.
DR   ExpressionAtlas; O62697; baseline and differential.
DR   Genevisible; O62697; SS.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0019898; C:extrinsic component of membrane; ISS:UniProtKB.
DR   GO; GO:1990742; C:microvesicle; ISS:UniProtKB.
DR   GO; GO:0097225; C:sperm midpiece; ISS:UniProtKB.
DR   GO; GO:0031731; F:CCR6 chemokine receptor binding; ISS:UniProtKB.
DR   GO; GO:0042056; F:chemoattractant activity; IBA:GO_Central.
DR   GO; GO:0042802; F:identical protein binding; ISS:UniProtKB.
DR   GO; GO:0035584; P:calcium-mediated signaling using intracellular calcium source; ISS:UniProtKB.
DR   GO; GO:0019933; P:cAMP-mediated signaling; ISS:UniProtKB.
DR   GO; GO:0060326; P:cell chemotaxis; IBA:GO_Central.
DR   GO; GO:0042742; P:defense response to bacterium; IBA:GO_Central.
DR   GO; GO:0050829; P:defense response to Gram-negative bacterium; ISS:UniProtKB.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; ISS:UniProtKB.
DR   GO; GO:0060474; P:positive regulation of flagellated sperm motility involved in capacitation; ISS:UniProtKB.
DR   InterPro; IPR001855; Defensin_beta-typ.
DR   InterPro; IPR006080; Defensin_beta/alpha.
DR   Pfam; PF00711; Defensin_beta; 1.
DR   SMART; SM00048; DEFSN; 1.
PE   3: Inferred from homology;
KW   Antibiotic; Antimicrobial; Defensin; Disulfide bond; Membrane;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   PROPEP          21..23
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000006957"
FT   PEPTIDE         24..64
FT                   /note="Beta-defensin 1"
FT                   /id="PRO_0000006958"
FT   DISULFID        31..60
FT                   /evidence="ECO:0000250"
FT   DISULFID        38..53
FT                   /evidence="ECO:0000250"
FT   DISULFID        43..61
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   64 AA;  7066 MW;  0A4B7494BA3E337A CRC64;
     MRLHRLLLVF LLMVLLPVPG LLKNIGNSVS CLRNKGVCMP GKCAPKMKQI GTCGMPQVKC
     CKRK