DEFB1_RAT
ID DEFB1_RAT Reviewed; 69 AA.
AC O89117;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Beta-defensin 1;
DE Short=BD-1;
DE Short=rBD-1;
DE AltName: Full=Defensin, beta 1;
DE Flags: Precursor;
GN Name=Defb1;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Goto-Kakizaki; TISSUE=Kidney;
RA Page R.A., Malik A.N.;
RT "Rat beta defensin-1 peptide: candidate marker for diabetic nephropathy.";
RL Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC STRAIN=Wistar;
RX PubMed=10456937; DOI=10.1128/iai.67.9.4827-4833.1999;
RA Jia H.P., Mills J.N., Barahmand-Pour F., Nishimura D., Mallampali R.K.,
RA Wang G., Wiles K., Tack B.F., Bevins C.L., McCray P.B. Jr.;
RT "Molecular cloning and characterization of rat genes encoding homologues of
RT human beta-defensins.";
RL Infect. Immun. 67:4827-4833(1999).
CC -!- FUNCTION: Has bactericidal activity. May act as a ligand for C-C
CC chemokine receptor CCR6. Positively regulates the sperm motility and
CC bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and
CC triggers Ca2+ mobilization in the sperm which is important for its
CC motility. {ECO:0000250|UniProtKB:P60022}.
CC -!- SUBUNIT: Monomer. Homodimer. {ECO:0000250|UniProtKB:P60022}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P60022}. Membrane
CC {ECO:0000250|UniProtKB:P60022}. Note=Associates with tumor cell
CC membrane-derived microvesicles. {ECO:0000250|UniProtKB:P60022}.
CC -!- TISSUE SPECIFICITY: Highly expressed in kidney.
CC {ECO:0000269|PubMed:10456937}.
CC -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR EMBL; AF093536; AAC61871.1; -; mRNA.
DR EMBL; AF068860; AAC28071.1; -; mRNA.
DR RefSeq; NP_113998.1; NM_031810.1.
DR AlphaFoldDB; O89117; -.
DR SMR; O89117; -.
DR STRING; 10116.ENSRNOP00000018428; -.
DR PaxDb; O89117; -.
DR Ensembl; ENSRNOT00000018427; ENSRNOP00000018428; ENSRNOG00000013768.
DR GeneID; 83687; -.
DR KEGG; rno:83687; -.
DR UCSC; RGD:619943; rat.
DR CTD; 1672; -.
DR RGD; 619943; Defb1.
DR eggNOG; ENOG502TDMV; Eukaryota.
DR GeneTree; ENSGT00940000166542; -.
DR HOGENOM; CLU_189296_1_0_1; -.
DR InParanoid; O89117; -.
DR OMA; SGKAKCC; -.
DR OrthoDB; 1584343at2759; -.
DR PhylomeDB; O89117; -.
DR Reactome; R-RNO-1461957; Beta defensins.
DR Reactome; R-RNO-1461973; Defensins.
DR PRO; PR:O89117; -.
DR Proteomes; UP000002494; Chromosome 16.
DR Bgee; ENSRNOG00000013768; Expressed in kidney and 13 other tissues.
DR Genevisible; O89117; RN.
DR GO; GO:0005615; C:extracellular space; ISO:RGD.
DR GO; GO:0019898; C:extrinsic component of membrane; ISS:UniProtKB.
DR GO; GO:1990742; C:microvesicle; ISS:UniProtKB.
DR GO; GO:0097225; C:sperm midpiece; ISS:UniProtKB.
DR GO; GO:0031731; F:CCR6 chemokine receptor binding; ISS:UniProtKB.
DR GO; GO:0042802; F:identical protein binding; ISS:UniProtKB.
DR GO; GO:0002526; P:acute inflammatory response; IEP:RGD.
DR GO; GO:0019731; P:antibacterial humoral response; ISO:RGD.
DR GO; GO:0061844; P:antimicrobial humoral immune response mediated by antimicrobial peptide; ISO:RGD.
DR GO; GO:0035584; P:calcium-mediated signaling using intracellular calcium source; ISS:UniProtKB.
DR GO; GO:0019933; P:cAMP-mediated signaling; ISS:UniProtKB.
DR GO; GO:0042742; P:defense response to bacterium; ISO:RGD.
DR GO; GO:0050829; P:defense response to Gram-negative bacterium; ISS:UniProtKB.
DR GO; GO:0050830; P:defense response to Gram-positive bacterium; ISS:UniProtKB.
DR GO; GO:0045087; P:innate immune response; ISO:RGD.
DR GO; GO:0002227; P:innate immune response in mucosa; ISO:RGD.
DR GO; GO:0060474; P:positive regulation of flagellated sperm motility involved in capacitation; ISS:UniProtKB.
DR GO; GO:0009617; P:response to bacterium; ISO:RGD.
DR GO; GO:0033574; P:response to testosterone; IEP:RGD.
DR InterPro; IPR001855; Defensin_beta-typ.
DR Pfam; PF00711; Defensin_beta; 1.
PE 2: Evidence at transcript level;
KW Antibiotic; Antimicrobial; Defensin; Disulfide bond; Membrane;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT PROPEP 22..32
FT /evidence="ECO:0000250"
FT /id="PRO_0000006959"
FT PEPTIDE 33..69
FT /note="Beta-defensin 1"
FT /id="PRO_0000006960"
FT DISULFID 37..66
FT /evidence="ECO:0000250"
FT DISULFID 44..59
FT /evidence="ECO:0000250"
FT DISULFID 49..67
FT /evidence="ECO:0000250"
SQ SEQUENCE 69 AA; 7837 MW; 66B1F0C29BB5C991 CRC64;
MKTHYFLLVM LFFLFSQMEL GAGILTSLGR RTDQYRCLQN GGFCLRSSCP SHTKLQGTCK
PDKPNCCRS
